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Antigene peptide nucleic acid specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosis Roberto Tonelli,Stefania Purgato,Consuelo Camerin,Raffaele Fronza,Fabrizio Bologna,Simone Alboresi,Monica Franzoni,Roberto Corradini,Stefano Sforza,Andrea Faccini,Jason M. Shohet,Rosangela Marchelli,and Andrea Pession Department of Pediatrics, University of Bologna,Sant'Orsola-Malpighi Hospital, Bologna, Italy; Department of Organic and Industrial Chemistry, University of Parma, Parma,Italy; and 3Center for Cell and Gene Therapy, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas Abstract We developed an antigene peptide nucleic acid for selective inhibition of MYCN transcription in neuroblastoma cells, targeted against a unique sequence in the antisense DNA strand of exon 2 of MYCN and linked at its NH2 terminus to a nuclear localization signal peptide.

抗原肽核酸抑制MYCN具体表达的神经母细胞瘤细胞，导致细胞生长的抑制和凋亡罗伯托利，斯特凡Purgato ，苏埃洛卡默琳，拉菲尔Fronza ，梅奥尼博洛尼亚，西蒙娜Alboresi ，莫妮卡弗兰索尼，罗伯托Corradini ，斯特凡诺斯福尔扎，安德烈Faccini ，杰森先生Shohet ， Rosangela Marchelli ，和安德烈Pession儿科，博洛尼亚大学，圣' Orsola -马尔皮基医院，博洛尼亚，意大利；有机部和工业大学化学帕尔马，帕尔马，意大利和3Center的细胞和基因治疗，德州儿童癌症中心， Baylor医学院，得克萨斯州休斯敦摘要我们开发了一种抗原肽核酸的选择性抑制神经母细胞瘤MYCN转录细胞，针对一个独特的序列反义DNA链的第2外显子，并与在MYCN 其氨基端为核定位信号肽。

It is a challenge to obtain consumer profile and preference in advertising campaigns, and using database, email and SMS to communicate with targeted consumers precisely.

如何在广告战役中，获得消费者的信息以及消费者喜好的信息，并利用数据库、电邮、短讯等方式，最精凖的与目标消费者沟通，是一个挑战。

Ads are conventionally targeted at the masses through the various media of TV, radio, newspapers and magazines.

广告是传统针对人民群众通过各种媒体的电视，广播，报纸和杂志。

If you can attract more targeted traffic you will have a better chance of converting them into actual sales.

如果您可以吸引更多的目标流量，您将有更好的机会其转化为实际销售。

Dr Mark Avery, of the Royal Society for the Protection of Birds, said:'The report shows that when targeted conservation programmes are funded, species such as stone-curlew, corncrake and bittern can often quickly recover.

英国皇家鸟类保护协会的马克？艾弗里博士说：这项报告显示，当环境保护项目得到拨款时，诸如大石鸻秧鸡麻鸦之类的物种都可以很快恢复生机。

Sure, this unit is targeted at the silent crowd, but is it really going to be quieter than the Corsair?

好吧，这个龙影是瞄准的静音市场，但是它真的比海盗船安静很多么？

Fights crow's feet, undereye lines, crepiness and more with 3 highly targeted technologies: Sirtuin EX1, Biomimetic Barrier Lipids and 5 times the concentration of TriHyaluronic Complex.

undereye线，更多的crepiness和针对性很强的技术3： Sirtuin EX1 ，血脂及仿生壁垒5倍浓度的TriHyaluronic复杂。

Aconnector is an injection molding from the positioning kits and installed in the positioning of the Inner-Block, packaged in the seat of the spring and reed composition, described the position set of cylindrical Chengyuan, the location of the hole sets A circular from the convex to capacity at the first spring home district and the Department of card system for the second district of the blocks in the positioning of the sets of holes in the first referred to the Ministry, since the port inside the shaft Two symmetrical to the hole within the targeted slot, a connector and adapter combination of positioning, positioning slot in the rear, the agreement sets in the central part of setting the level of L-shaped slots, so that the connector and adapter reliable combination of the Practical use of new high-strength engineering materials first injection molding, greatly simplified the process, a connector improve the accuracy of the positioning trough of the utility model to improve, even if the products improve the safety and reliability, and more convenient assembly, product structure is simple And optimize the manufacturing process, reducing costs and improve productivity.

一种连接器是由注塑一次成型的定位套和安装在定位套内的机座、套装在机座上的弹簧和簧片组成，所述的定位套呈圆柱状，该定位套的内孔由一内凸圆隔出容置弹簧的第一区部和卡制机座的第二区部，在定位套的内孔，位于所述的第一区部处，自端口向内，轴向对称设置两条内孔定位槽，起到连接器与适配器结合的定位作用，在该定位槽尾部，约定位套的中部设置L形水平槽孔，使连接器与适配器可靠结合；本实用新型采用高强度工程材料一次注塑成型，大大简化了加工过程，提高了一种连接器的精确度，本实用新型定位槽的改进，即使产品安全可靠性提高，又更方便组装，产品结构简单、制造工艺优化，从而降低了成本，提高了生产率。

A connector is an injection molding from the positioning kits and installed in the positioning of the Inner-Block, packaged in the seat of the spring and reed composition, described the position set of cylindrical Chengyuan, the location of the hole sets A circular from the convex to capacity at the first spring home district and the Department of card system for the second district of the blocks in the positioning of the sets of holes in the first referred to the Ministry, since the port inside the shaft Two symmetrical to the hole within the targeted slot, a connector and adapter combination of positioning, positioning slot in the rear, the agreement sets in the central part of setting the level of L-shaped slots, so that the connector and adapter reliable combination of the Practical use of new high-strength engineering materials first injection molding, greatly simplified the process, a connector improve the accuracy of the positioning trough of the utility model to improve, even if the products improve the safety and reliability, and more convenient assembly, product structure is simple And optimize the manufacturing process, reducing costs and improve productivity.

一种连接器是由注塑一次成型的定位套和安装在定位套内的机座、套装在机座上的弹簧和簧片组成，所述的定位套呈圆柱状，该定位套的内孔由一内凸圆隔出容置弹簧的第一区部和卡制机座的第二区部，在定位套的内孔，位于所述的第一区部处，自端口向内，轴向对称设置两条内孔定位槽，起到连接器与适配器结合的定位作用，在该定位槽尾部，约定位套的中部设置L形水平槽孔，使连接器与适配器可靠结合；本实用新型采用高强度工程材料一次注塑成型，大大简化了加工过程，提高了一种连接器的精确度，本实用新型定位槽的改进，即使产品安全可靠性提高，又更方便组装，产品结构简单、制造工艺优化，从而降低了成本，提高了生产率。

With more and more economic data out of the Government's decision-making will be more targeted.

目前，在政府的决定越来越多的经济数据决策将更有针对性。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。