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The results showed the serum IL-2 levels were significantly lower in the patients than that of the controls(P.05),indicated the imbalance of immune functions,The decreased IL-2 levels may decrease natural killer cells and lymphokine-activated killer cells activity,causing reduction of the virus infected target cytolysis may be one of the important reasons in the recurrence of the disease.

结果发现病人血清IL－2水平比对照组明显降低（P＜0.05），说明该病存在免疫功能失调。IL－2水平低下，导致由IL－2诱生的NK和LAK细胞活性降低，使它们溶解和破坏病毒感染靶细胞能力低下，此可能是该病不断复发的重要原因之一。

Abstract］ AIM: To construct recombinant vectors expressing siRNA that target CD59 gene and a stableinhibit cell line A2780 in order to analyze the role of CD59 in the protection to complementmediated cytolysis.

摘 要］目的：构建针对人CD59基因的siRNA表达载体并筛选稳定细胞系，观察CD59基因改变后对补体溶破的抵抗作用的变化，探讨CD59在肿瘤细胞免疫逃逸及相关信号转导通路中的作用。

In contrast, cancer cells lacking functional P53 would be expected to be sensitive to viral replication and subsequent cytolysis. However P53 defections wildly exist in most of human cancer cell, deletion of E1B-55kD gene can make the adenovirus target at p53 mutation tumor cell.

以往的研究表明，大部分人类肿瘤中均存在p53基因突变，因此E1B55kD蛋白缺失的重组病毒只能在P53功能异常的肿瘤细胞中复制，而在正常细胞中该重组病毒由于缺乏对抗P53蛋白的病毒产物，不能有效复制，因此具有肿瘤靶向治疗的特点。

OBJECTIVE: BMSCs from osteoporosis rats were isolated and cultured in vitro. To observe biological features of BMSCs of rat models of osteoporosis, to analyze cytopathology mechanism of osteoporosis, and to provide a significant drug target for prevention and treatment of osteoporosis.

目的：对骨质疏松大鼠骨髓间充质干细胞进行分离和体外培养，观察骨质疏松模型大鼠骨髓间充质干细胞的生物学特性，分析骨质疏松的细胞病理学机制，以期为骨质疏松的防治提供一个有意义的药物靶标。

PSE7 and SOJB had the similar binding proteins in tobacco, suggesting that they may share some similar biological functions. The ubiquitin-conjugating protein and peptidase involved in protein degradation were found binding with SOJB but not PSE7. Both SOJB and PSE7 could bind with transmembrane transport protein, SOJB bound with copper transporter protein, and PSE7 bound with water channel protein. The results suggested that the target of SOJB and PSE7 may be located in cytoplast.

PSE7和SOJB在烟草中存在几个相似的结合蛋白，表明二者具有共享的生物学功能；SOJB能与肽酶和泛素结合蛋白（与蛋白质降解有密切关系）互作，而PSE7没有筛选到类似蛋白；SOJB和PSE7均能与跨膜运输蛋白结合，PSE7与水通道蛋白结合，SOJB与铜离子转运蛋白结合，表明二者在胞质内均存在作用靶标。

Essential amino acid residues in diphtheria toxin catalytic domain were determined by quantum chemistry calculation and the enzymatic activities of mutant in the active-site were tested in order to provide high effective cytotoxin for target anticancer drugs.

通过量子化学计算确定白喉毒素分子催化区活性中心的关键氨基酸残基，评价其取代后的酶活性的改变，为导向性抗癌药物研究提供高效杀伤细胞工具。

With cells 7404 as the target cells, the killer role of rIL-2 and cytotoxin of LAK cells in the case of pH 6.8, 7.3 and 7.6 will be assayed one by one by the MTT method.

应用细胞计数方法观察pH值分别为6.8、7.3、7.6的培养液，对rIL-2激活单个核细胞的影响。

With cells 7404 as the target cells, the killer role of rIL-2 and cytotoxin of LAK cells in the case of pH 6.8, 7.3 and 7.6 will be a ayed one by one by the MTT method.

应用细胞计数方法观察pH值分别为6.8、7.3、7.6的培养液，对rIL-2激活单个核细胞的影响。

RESULTS: The polymerase chain reaction product was in concordance with target fragment. The analysis of the gene sequence proved it is the ALR gene. The overall length of the ALR gene was 378 bp, it was highly conservative in many species, for instance the Homo sapiens, the Mus musculus, the Bos Taurus and the Danio rerio.

结果：聚合酶链反应扩增结果与目的片段位置一致，测序结果表明为肝再生增强因子mRNA，基因全长378 bp，在人、牛、小鼠、斑马鱼等物种中高度保守。

Objective To evaluate the lasting time of background luminance difference of the fixation target between two eyes because of dark adaptation under routine subjective refraction.

目的 探讨在常规主觉验光环境下，暗适应造成的双眼前视标背景亮度差异的持续时间。

However it can often be frust ating for a child when people are unable to pronounce their name.

但它往往可以令人沮丧的一个孩子当人们无法断言他们的名字。

All these compounds were obtained from this genus for the first time. Compound, 4-cumylphenol, was a new nature product.

所有化合物均为首次从本属海藻中分离得到，其中4cumylphenol为新天然产物。