查询词典 synaptic

In clinical. acetylcholinesterase inhibitors reduce the breakdown of synaptic acetylcholine, have been modestly effective in improving the cognitive deficits of Alzheimer's disease.The goal of this work is to determine enzyme kinetics and mechanisms of acetylcholinesterase and butyrlcholinesterase inhibition by five cardiovascular drugs, lovastatin, simvastatin, amlodipine besylate, nifedipine, and hydralazine hydrochloride, and two benzodiazepines, diazepam and chlordiazepoxide hydrochloride. All drugs in this study are reversible mixed-type inhibitors of acetylcholinesterase and butyrylcholinesterase. The pKi values for acetylcholinesterase and butyrylcholinesterase inhibition by the cardiovascular drugs are linearly correlated with the molecular weights of the drugs with the slopes of 0.005 and 0.0021, respectively. Therefore, van der Waals' interactions between acetylcholinesterase and the cardiovascular drugs are stronger than those between butyrylcholinesterase and the drugs. This is probably due to a smaller active site gorge and a more significant peripheral anionic substrate binding site of acetylcholinesterase than those of butyrylcholinesterase.

本研究之目的系决定乙醯胆碱酯酵素和丁醯胆碱酯酵素被五种心脏血管药物lovastatin， simvastatin， amlodipine besylate， nifedipine、hydralazine hydrochloride和两种benzodiazepines：diazepam和Chlordiazepoxide hydrochloride的抑制作用之动力学及机转，这些药物都是乙醯胆碱酯酵素和丁醯胆碱酯酵素的可逆性、混合型之抑制剂，实验结果显示，五种心血管药物对於乙醯胆碱酯酵素及丁醯胆碱酯酵素抑制之pKi值和药物之分子量呈直线之关系，斜率分别为0.005及0.0021因此丁醯胆碱酯酵素，与心血管药物间之凡德瓦作用（van der Waals' ）比乙醯胆碱酯酵素与心血管药物间者弱，这可能原因是丁醯胆碱酯酵素之活性区域比乙醯胆碱酯酵素之活性区域更宽广，但丁醯胆碱酯酵素之周边阴离子区域不及乙醯胆碱酯酵素之周边阴离子区域者明显重要，由於五种心血管药物对於乙醯胆碱酯酵素和丁醯胆碱酯酵素抑制之pKi值存在著线性关系表示此种抑制作用系经过共同之反应机理。

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Compare with the curvation forms of synaptic interfac e of control animals and 3days after KA administration animals,the amount of smi le synapses is significantly decresed and the amount of frown synapses is signif icantly increased in the moleculous layer of d entate gyrus 7 days after KA injection.

与对照组及KA注射后3d组相比，KA注射后7d大鼠DG分子层内的突触中，笑型突触所占突触总数的比例显著减少，愁型突触所占突触总数的比例显著增加。

AIM: To observe the effect of total ginsenoside on synaptic transmission in the dentate gyrus.

目的：研究人参总皂苷对麻醉大鼠海马齿状回突触传递活动的影响。

Likewise, brief spontaneous increases in [Ca2+]i, sensitive to BMI and TTX, are observed at the same ages, suggesting that endogenous synaptic GABAA receptor activation can depolarize cells and activate VGCCs.

同样，短暂的[Ca2+]i自然上升对BMI和TTX敏感，可以在相同年龄上观察到，这显示出内圣突触GABBA受体活化可以为细胞去极化，并活化VGCCs。

They express widely inperipheral and central nerve system and participate in many important physiological andpathological processes,such as learning and memroy,synaptic plasticity,cerebral ischemiaand pain.Activation of ASICs by protons can depolarize the neurons and generate action potentials.

它广泛分布于中枢及外周神经系统的神经元，参与了很多重要的生理过程和病理反应，与学习记忆、突触可塑性、脑缺血、疼痛等关系密切。H~+激活ASICs可使神经元去极化，产生动作电位，参与了组织酸化如缺血、炎症、肿瘤、癫痫等时痛觉的感受。

Indeed,〓receptor desensitization is fast enough to control the time course of GABA-evoked synaptic events.

实际上，〓受体的脱敏速度已足以控制GABA诱发的突触事件。

We has discussed the mechanism of the trivalent synaptic adjustment,and it's important use to control the chiasmata and disjunction of the chromosomes.

本文对此三价体的联会调节机制及其对控制染色体交叉重组和染色体分离所起的重要作用进行了讨论。

Title: Effect of CUZHIFANG on Ethology and Synaptic Plasticity in hippocampus of aged learning and memory impaired rate.

论文题目："促智方对老年学习记忆减退大鼠行为学及海马突触可塑性的实验研究"。

Intracellular recordings were made from neurons in the superfused isolated carpretina and the effects of calcium on synaptic transmission from cones and rods to horizontal cells were studied by changing the ionic composition of the external medium.

工作应用细胞内记录技术，在灌流的卿鱼离体视网膜的标本上，研究了低钙对外网状层中视锥、视杆信号向水平细胞传递的不同影响。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。