查询词典 suppressor

Clonal anergy and suppressor cells are main mechanisms of the tolerance.

克隆不应答和抑制细胞是耐受的主要机制。

Methylation of CpG islands in the promoters induces gene silencing. The multiple tumor suppressor gene P16, located at chromosome 9p21, regulating normal proliferation of cells with a functional unit constituting of p16, cyclin D1 and pRb together. Methylation of P16 gene has been detected in several lymphocytic and plasmacytic malignancies such as lymphoma, acute lymphocytic leukemia and multiple myeloma and shows relationships with the pathogenesis of these diseases. Application of demethylation agents or arsenical to refresh the gene functions will be expected to be a new treatment for hemopoietic malignancies.

基因启动子区CpG岛甲基化常导致基因沉默。P16基因是一定位于9p21的多种肿瘤抑制基因，通过pl6INK4Acyclin D1-PRb通路维持机体细胞的有序增殖。P16基因甲基化在淋巴瘤、急性淋巴细胞性白血病、多发性骨髓瘤等多种淋巴细胞浆细胞肿瘤中被检测到，并与疾病的发生、发展存在一定关系，应用甲基化抑制因子或砷剂去甲基化治疗，恢复基因功能可望成为血液恶性肿瘤治疗的一种新手段。

The effect of the suppressor on the determination of cations was studied and the relationship between response conductivity of cations and suppressor current intensity was discussed.

探讨了离子抑制反应对阳离子测定的影响以及阳离子响应电导和抑制电流强度的关系。

Mutants related to shoot branching are isolated in pea? Arabidopsis? petunia? rice? tomato and maize, such as revoluta? pinhead? monoculm1(moc1)? lateral suppressor? blind/torosa related to axillary meristem initiation; more axillary growth? ramosus? decreased apical dominance associated with axillary meristem outgrowth; supershoot/bushy? Teosinte branched1 (Tb1) contacted with axillary meristem initiation and outgrowth.

在豌豆、拟南芥、矮牵牛、水稻、番茄和玉米中获得到很多与分枝发育相关的突变体，如与腋生分生组织的形成有关的revoluta、pinhead、monoculm1(moc1)、lateral suppressor、blind/torosa等突变体；与腋生分生组织的生长有关的more axillary growth、ramosus、decreased apical dominance等突变体；与腋生分生组织的形成和生长都有关的、supershoot/bushy、teosinte branched1(tb1)等突变体。

The big difference between these two alternatie ways that tumour cells use to inactiate tumour suppressor genes is that, while the reersal of genetic alterations is technically almost unfeasible in clinical scenarios, the function of these epigenetically inactiated suppressor genes is easily reactiated by pharmacological means.

这两种改变方式最大的不同之处在于肿瘤细胞利用失活的肿瘤抑制基因，而在同时相反的遗传学改变在临床方案上是很难实施的技术。

To study the regulation mechanism of SOCS-3 (Suppressor of cytokines signals-3) for erythropoietic development, small interference RNA expression vectors of SOCS-3 were constructed and transferred in to the K562 cell lines stably by lentiviral system.

为了研究细胞因子信号转导分子3(suppressor of cytokine signals-3，SOCS-3)对造血发育的影响，构建了SOCS-3慢病毒siRNA干涉载体，并转染人红白血病细胞株K562。

The resulting strain, designated YES2MTM1, was transformed with a yeast genomic library. Transformants lost the plasmid overexpressing MTM1 after 5-FOA treatment. Yeast strains able to grow on nonfermentable carbon source with MTM1 deletion and overexpression of some DNA fragments were picked up and candidate suppressor genes were identified. Overexpression of five genes were identified to be able to rescue the growth defect on nonfermentable carbon source. The study will provide reference for MTM1 gene function and screening for suppressor of genes whose deletion result in irreversible damage.

为了避免MTM1缺失造成的不可逆损伤，在野生型酵母中先转入带有MTM1 基因的质粒，再敲除染色体上的MTM1 基因，随后转入基因组文库，再利用药物5-氟乳清酸(5-FOA)迫使细胞丢失表达MTM1基因的外源质粒，再筛选能在非发酵培养基上生长的转化子，通过这种方法筛选发现，POR2等5个基因的过表达可以挽救MTM1 基因缺失造成的非发酵培养基上的生长缺陷，为深入了解MTM1基因的功能提供了线索，对筛选其他造成不可逆损伤的突变基因的抑制基因提供了一条可行的研究思路。

To obtain more information of magnesium homeostasis in mitochondria, mTn-lacZ/LEU2 transposon library was transformed into mrs2 deletion mutant to screen for suppressor genes of MRS2. YMR166C, a member of mitochondrial carrier family, was identified as a suppressor gene of MRS2. Deletion of YMR166C gene can rescue the defects of mrs2 deletion mutant such as the decrease in mitochondrial magnesium concentration, Group II RNA splicing defect and growth defect on nonfermentable carbon source. For the first time we demonstrated YMR166C is involved in mitochondrial magnesium homeostasis.

为了增进对线粒体镁离子代谢调控基因的了解，利用酿酒酵母mTn-lacZ/LEU2转座子文库筛选MRS2的抑制基因，发现线粒体载体家族成员YMR166C基因的缺失可以挽救MRS2基因缺失的突变体的生长缺陷、II型内含子剪接缺陷，并可以调节线粒体镁离子浓度，首次发现YMR166C是线粒体镁代谢相关基因。

Suppressor is the key part for IC instrument, and developing a high performance suppressor for IC instrument is quite important to gradient ion chromatography, to analysis of some ions which have strong affinities with the functional groups located on the surface of the pellicular ion exchange column packing.

抑制柱是离子色谱仪的一个核心部件，研制具有较高抑制容量的抑制柱对于离子色谱法的梯度淋洗、对于在分离柱上保留时间长的离子分析具有重要的意义。

Part-3 Tumor Suppressor Gene PTEN Up-regulates p53 Level and Sensitizes Hepatocellular Carcinoma Cells to Chemotherapy Objective: To investigate the effects and the mechanisms of tumor suppressor gene PTEN on level of p53 protein and sensitivity of HepG〓 cells to chemotherapy.

第三部分 PTEN在肝癌细胞中上调p53蛋白水平并增强化疗药物敏感性目的：研究抑癌基因PTEN对肝癌细胞化疗药物敏感性及p53蛋白水平的影响，并探讨相关机制。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。