查询词典 sulfatase

These findings suggest a mechanism for the selective uptake of BPA into cells expressing estrone sulfatase.

由这些发现可推测细胞在表达雌激素酮硫酸酯酶时选择性吸收BPA的机制。

BPA is a substrate for estrogen sulfotransferase, and bisphenol A sulfate and disulfate are substrates for estrone sulfatase.

BPA是一个雌激素磺酸转移酶的底物，且二苯A硫酸盐和脱硫酸盐是雌激素酮硫酸酯酶的底物。

Five fetuses were diagnosed with female pseudohermaphroditism (21-hydroxylase deficiency in 3 and urorectal septum malformation sequence in 2). Four fetuses were diagnosed with male pseudohermaphroditism (1 with steroid sulfatase deficiency, 1 with presumed camptomelic dysplasia, and 2 undetermined).

在这16个胎儿中有5个被诊断为女性假两性畸形（其中3个有21-羟化酶分泌不足，2个有尿道直肠隔畸形），4个被诊断为男性假两性畸形（其中1个有类固醇硫酸酯酶分泌不足，1个推测可能为弯肢性发育异常，另外2个原因未定），5个有染色体异常，2个有性逆转，核型为（46，XX+SRY）。

The disorder had been reported to be due to a deficiency of glucosamine-6-sulfate sulfatase.

这种疾病已经报告给是由於缺乏氨基葡萄糖- 6 -硫酸粘多醣。

Results: Mdroxyprogesterone acetate plus E2 (10-8 M) stimulated both the mRNA levels and activities of sulfatase (at 10-8-10-6 M) compared to E2 only.

用同位素标记的底物和RT-PCR技术分别测定硫酸酯酶和硫转移酶的活性和mRNA表达水平。

By studying the mouse models of two LSDs associated with severe neurodegeneration, Multiple Sulfatase Deficiency and Mucopolysaccharidosis type IIIA, we observed an accumulation of autophagosomes resulting from defective autophagosome-lysosome fusion.

通过研究与严重的神经变性有关的二个LSDs 模型，多发的硫酸酯酶缺乏和IIIA型粘多糖病，我们观察到从有缺陷的自噬体-溶酶体结合导致的自噬体的积聚。

Key wrds: hormone replacement therapy; breast cancer cells; progestin; estrogen-metabolizing enzyme; sulfatase; sulfotransferase

对于目前激素替代治疗中常用的孕激素安宫黄体酮是否可以通过影响雌激素代谢酶的活性而增加乳腺癌的危险性，尚有待于更深入的研究。

These two series of probes differ in their mechanism of action. The first series exploits the concept of suicide substrate. When the probe is hydrolyzed by the target sulfatase, it will release an intermediate that undergoes elimination to form a reactive quinone methide which in turn reacts with nearby nucleophiles. The second series belongs to an electrophilic reagent which utilizes a cyclic sulfamate moiety serving both as the recognition unit and the trapping device.

这二系列标示分子的主要差异在於其标示机制，第一系列是源自於自杀性受质的概念，利用水解后的中间体会生成高反应性的quinone methide，来达到标示的效果；第二系列则是属於亲核性试剂型，采用环状胺基磺酸衍生物做为辨识端及捕捉机制，预期在其进入酵素的受质结合区后能与酵素催化中心形成共价键结。

Metabolic cherry-red spot occurs in other lysosomal enzyme deficiences such as generalized gangliosidosis (GM 1), Sandhoff's, Gaucher's, mucolipidosis Types 1 and 2, Niemann-Pick Type A, and multiple sulfatase deficiency. Vision is usually subnormal because the ganglion cells are not working properly.

代谢性眼部樱桃红斑发生在许多溶酶体酶缺乏的疾病中出现，如GM1神经节苷脂贮积病，sandhoff病，高雪氏病，粘脂质贮积病1，2型，尼曼匹克病A型，及多种硫酸酯酶缺乏病等，由于神经节细胞异常，视力一般轻度受损。

1Livestock Research Institute, Council of Agriculture(2)Department of Animal Science, National Pingtung University of Science and TechnologyGenetic variation in the N-acetylglucosamine 6-sulfatase (G6S) gene is the key role in caprine Mucopolysaccharidosis IIID.

本研究建立山羊黏多醣症遗传缺陷之单股构型多态性基因型检测方法，应用此方法来检测乙醯醣胺氨基硫酸酶(N-acetylglucosamine 6-sulfatase， G6S)基因型不再需要使用限制酶，可节省检测时间、成本与人力。G6S基因的遗传变异在山羊黏多醣症第三型扮演重要的角色。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失