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An antibody binding to IGF-IR and inhibiting the binding of IGF-I and IGF-II to IGF-IR which is characterized in that said antibody is a is ofIgG1 isotype, b shows a ratio of IC50 values of inhibition of the binding of IGF-I to IGF-IR to the inhibition of binding of IG-II to IGF-IR of 1:3 to 3:1, c inhibits for at least 80% at a concentration of 5 nM IGF-IR phospohrylation in a cellular phosphorylation assay using 3T3 cells providing 400,000 to 600,000 molecules IGF-IR per cell in a medium containing 0.5% heat inactivated fetal calf serum when compared to such an assay without said antibody, and d shows no IGF-IR stimulating activity measured as IGF-IR phophorylation at a concentration of 10 M in a cellular phosphorylation assay using 3T3 providing 400,000 to 600,000 molecules IGF-IR per cell in a medium containing 0,5% heat inactivated fetal calf serum when compared to such an assay without said antibody has improved properties in antitumor therapy.

一种已经提高了抗肿瘤治疗的特性的抗体，所述抗体结合IGF-IR并且抑制IGF-I和IGF-II与IGF-IR结合，其特征在于所述抗体a是IgG1同种型，b显示其对IGF-I与IGF-IR结合的抑制的IC 50 值与其对IGF-II与IGF-IR结合的抑制的IC 50 值的比率为1∶3-3∶1，c当与没有所述抗体的这种测定比较时，其在5nM的浓度上，在包含0.5％的热灭活胎牛血清的培养基中，使用3T3细胞的细胞磷酸化测定中，抑制至少80％的IGF-IR磷酸化，所述3T3细胞提供400，000-600，000分子IGF-IR/细胞，和d当与没有所述抗体的这种测定相比，在包含0.5％的热灭活胎牛血清的培养基中，使用3T3的细胞磷酸化测定中，其在10μM的浓度上没有显示作为IGF-IR磷酸化所测量的IGF-IR刺激活性，所述3T3提供400，000-600，000分子IGF-IR/细胞。

The experiment obtains clone pig HUMMLC2B gene (GenBank logs onto date: DQ533994), use PCR-RFLP technology, analysed HUMMLC2B gene the 1st embedded child medium Msp Ⅰ is enzymatic cut much condition (T613C) is in distributinging; analysed the much condition sex in 7 breed pig 5 many condition sex and 36 long white pigs, groups 104 pigs and grow to be mixed in vain 5, the result makes clear, the scale that waits for a gene and B to wait for a gene frequency except the A in long white pig in detected swinery is 1 ∶ 2 outside, of the others all take absolutely advantage for a gene such as B, and a gene such as A is pure close individual detect in long white pig only.

实验获得克隆猪HUMMLC2B基因(GenBank登录号：DQ533994)，并采用PCR-RFLP技术，分析了HUMMLC2B基因第1内含子中的MspⅠ酶切多态(T613C)在7个品种猪中的多态性分布；分析了多态性和36头长白猪、5个群体104头猪以及长白和5个群体之和的140头猪胴体性状和肉质性状间的相关，结果表明，在检测的猪群中除长白猪中A等位基因和B等位基因频率的比例为1∶2外，其余的均为B等位基因占绝对优势，且A等位基因纯合个体只在长白猪中检测到。

By countersigning this Agreement, each of the Shareholders, severally and not jointly, represents that such Shareholder is an accredited investor as such is defined in Regulation D promulgated under the Securities Act of 1933 as amended, because such Shareholder fits one of the definitions set forth

在签署本协议副本之时，每位Wealthlink公司股东均应单独声明：由于该股东符合本协议附件A的相关定义，该股东应视为1933年证券法D编所定义的合格投资者。

But when we see a lot of framed timbers, different portions of which we know have been gotten out at different times and places and by different workmen,--Stephen, Franklin, Roger, and James, for instance,--and when we see these timbers joined together, and see they exactly make the frame of a house or a mill, all the tenons and mortices exactly fitting, and all the lengths and proportions of the different pieces exactly adapted to their respective places, and not a piece too many or too few, not omitting even scaffolding--or, if a single piece be lacking, we see the place in the frame exactly fitted and prepared to yet bring such piece in--in such a case we find it impossible not to believe that Stephen and Franklin and Roger and James all understood one another from the beginning, and all worked upon a common plan or draft drawn up before the first blow was struck....

然而，当我们看到这许多木料组成的构架，它们不同的部件在不同的时间和地点由不同的工匠所造出──斯蒂芬、弗兰克林、罗杰和詹姆斯等等──当我们看到这些木料拼在一起，看到它们天衣无缝地组成了一座房子或一间工作坊的构架，所有的掉头和榫眼密切结合，一切构件的长度和大小都使其精确地各归其位，一块也不多，一块也不少，甚至也没忘了搭置脚手架──或者说如果构件少了一块的话，构架上也留下了一处空位来补其所缺──在这种情况下，我们觉得不可能不相信斯蒂芬、弗兰克林、罗杰和詹姆斯从一开头就心照不宣，共同制定出一个计划或方案，然后打出第一拳

It was such a period that the pluralities were instead reflected in the difference between ethnic communities such as the Guangfu and the Hakka people, who could be identified by their socio-cultural morphologies such as social organizations, dialects, etc.

当时的多重性主要反映在如广府与客家等族群的分别之上，他们可从其社会文化形态，如社会组织、方言等方面，界定各自的身分。

It also concludes some common problems of such a management in tobacco enterprises, and proffers some corresponding countermeasures to such issues, hoping such problems will be solved with the help of analysis on them

并归纳了一些在烟草企业财务管理方面普遍存在的问题，针对这些问题提出了相应的对策，希望通过财务管理问题的分析得以解决。

To raise or borrow and to secure or discharge any debt or obligation of the Company,and to receive money on deposit or loan in such a manner and on such terms as may seem expedient and in such manner as may be thought fit and in particular by mortgages and charges and the issue of debentures or debenture stock or other securities of any description upon all or any part of the undertaking,property,assets and rights of the Company both present and future including any uncalled capital of the Company.

以视为适宜的方式和按适宜的条款，以及以适当方式和具体用本公司目前，将来的全部或部分承诺、财产、资产和权利以及未收资金以按揭、抵押、发放债券或公司债票或任何类型的证券的方式，举债或借债并担保或解除本公司的债务或义务

To raise or borrow and to secure or discharge any debt or obligation of the Company,and to receive money on deposit or loan in such a manner and on such terms as may seem expedient and in such manner as may be thought fit and in particular by mortgages and charges and the issue of debentures or debenture stock or other securities of any de**ion upon all or any part of the undertaking,property,assets and rights of the Company both present and future including any uncalled capital of the Company.

以视为适宜的方式和按适宜的条款，以及以适当方式和具体用本公司目前，将来的全部或部分承诺、财产、资产和权利以及未收资金以按揭、抵押、发放债券或公司债票或任何类型的证券的方式，举债或借债并担保或解除本公司的债务或义务

Ltd. Deer farming in China belong to high-end industries, such as Yue Yao-min can be such a big entrepreneurs in the industry such ease.

养殖鹿在国内属于高端产业，如岳耀民这样的大手笔企业家方能在这样的行业内游刃有余。

Check the telephone line to connect the plug contacts, such as whether or not good, is it because of damp, such as connecting plugs Health aeruginosa resulted in poor contact, whether the line of skin damage occurs, the exposed inner core of such a phenomenon.

检查电话线的各连接插头等是否接触良好，是否因受潮而使连接插头等生铜绿导致接触不良，是否线路发生了外皮破损、内芯裸露等现象。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。