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That could help answer the question of whether some people are born with larger striatums than others, or whether this region becomes bigger as people develop certain skills, says Yaakov Stern, a cognitive neuroscientist at Columbia University.

哥伦比亚大学的认知神经科学家亚科夫·斯特恩说,该研究可能有助于解决这个问题:某些人的纹状体是否在出生时就比其他人的更大呢?或者,人们是否在逐渐掌握了特定的技巧之后纹状体才变大的?

L (12μg/4μd) 6-OHDA or 0.9% saline werethen injected into the right striatums of rats respectively according to the coordinatesmentioned before.

于注入后第7天插入微透析探针收集透析液并将其注入HPLC-ECD测定各组大鼠透析液中DA、DOPAC和HVA的含量。

Methods: The releases of Glu, Asp, Gly, Tau and GABA from rat striatums during 30,60,90,120 min of global ischemia were determined by microdialysis and HPLC methods.

用微透析结合高效液相法测定半球缺血30,60,90,120分钟时大鼠纹体Glu,Asp,Gly,Tau和GABA的释放。

The abnormal release of DA from ischemic striatums were significantly inhibited by L-NNA.

结果:大鼠半球缺血30分钟时,纹体DA的释放形成高峰,其后逐渐下降,但都高于缺血前释放量。L-NNA能明显抑制缺血时纹体DA的不正常释放。

However,all of the DA releases during 60,90,120min global ischemia were significantly higher than that before ischemia. The abnormal release of DA from ischemic striatums were significantly inhibited by L-NNA.

结果:大鼠半球缺血30分钟时,纹体DA的释放形成高峰,其后逐渐下降,但都高于缺血前释放量。L-NNA能明显抑制缺血时纹体 DA的不正常释放。

Results: Compared with NSCs group, more TH-positive cells were found in the NSCs+GDNF group transplanted into the striatums of PD rats. And NSCs+GDNF group could alleviate the apomorphine-induced rotations of PD rats.

结果:联合GDNF移植NSCs比单纯移植的NSCs较多的转化为多巴胺能神经元,并能够改善PD模型大鼠的旋转行为。

That could help answer the question of whether some people are born with larger striatums than others, or whether this region becomes bigger as people develop certain skills, says Yaakov Stern, a cognitive neuroscientist at Columbia University.

哥伦比亚大学的认知神经学家亚科夫·斯特恩认为,这项研究将有助于解答一个疑问,即有些人是否生来就有更大的纹状体,还是纹状体会随着人们某项技能的发展而逐渐变大。

Then NSCs were grafted into the striatums of PD rats with GDNF. Tyrosine Hydroxylase-positive cells were gradually increased at 30d after transplantation in the striatum of PD rats.

采用原代培养胚胎14.5天的胎鼠腹侧中脑NSCs,单独或经GDNF预处理后移植入PD模型大鼠的纹状体,观察NSCs在纹状体的分化情况,以及PD模型大鼠旋转行为的变化。

They were able to survive better and differentiate into TH〓 cells more strongly in 6-hydroxydopamine (6-OHDA)-lesioned striatums than in intact ones. Apomorphine-induced rotations were attenuated in MP grafted animals, too.

移植后发现,6-羟基多巴胺(6-OHDA)损伤的PD大鼠纹状体能促进MP或CP细胞的存活并分化成TH〓细胞,而且,MP双移植比单移植改善效果明显,也有助于黑质-纹状体DA神经通路的重建。

They were implanted thecannulas into the right striatums of rats according to the followingcoordinates:A:+0.2mm,L:+3mm,V:3.5mm and the microdialysates were collected andmeasured by HPLC-ECD 24h later. At the second step, 10 rats were divided intocontrol and model groups randomly.

第2批10大鼠在BMD和HPLC-ECD实验方法建立的基础上,随机分为对照组和模型组各5只,按照前述坐标定位至大鼠右侧纹状体,然后向模型组大鼠右侧纹状体内注入6-OHDA 12μg/4μl(用含0.1%抗坏血酸的0.9%氯化钠溶液配制)制作急性PD模型,对照组大鼠同一部位注射等量生理盐水。

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