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To study the applicable prospect of suicide gene on tumor therapy in clinic,we cloned the gene of D-amino acid oxidase and the gene of yeast cytosine deaminase.We hope to establish the transgenic mices of DAAO gene and YCD gene,and the two transgenic strain mices are valuable animal system for studying the biological characteristic of DAAO gene and YCD gene ,for studing the killing activity of DAAO/D-Ala and YCD/5-FC gene therapy systems on tumor.The D-amino acid oxidase gene derived from R.gracilis and it could oxidize D-amino acids. Hydrogen peroxide(H2O2) is a reactive oxygen species generated in the deamination of D-Ala catalyzed by DAAO.

为了探讨自杀基因在临床肿瘤治疗中的应用前景，建立自杀基因肿瘤治疗评价的动物模型，我们克隆了D-氨基酸氧化酶(D-amino acid oxidase，DAAO)基因和酵母菌胞嘧啶脱氨酶(yeast cytosine deaminase，YCD)基因，希望建立DAAO基因及YCD基因转基因小鼠，为研究DAAO及YCD基因的生物学特性、开发和评价DAAO／D-Ala及YCD／5-FC自杀基因系统进行肿瘤治疗建立良好的实验动物模型。

The dynamic stress-strain and welding residual stress during welding are the significant factors which lead to welded cracking and debasement of the joint properties.

在焊接过程中产生的动态应力应变及随后形成的残余应力，是导致焊接裂纹和接头性能下降的重要因素。

In the frame scheme of the two-phase MPM,the modified strong decohesion model is coupled with the bifurcation analysis of the stress-strain field,whose stress state is updated with the corresponding return mapping algorithm developed here.

为了考虑饱和多孔介质中的流—固耦合特性，本章在破坏本构描述中引入了孔隙压强的影响，提出了改进的strong decohesion模型，并发展了相应的返回映射算法。

To simulate the strain localization of saturated porous media,a modified strong decohesion model is developed in Chapter 7,in which the solid-fluid coupling in saturated porous media is considered with bringing the effect of pore pressure into the traction on the decohesion surface.

第七章，饱和多孔介质作为多相多孔材料，其应变局部化问题不仅与固体骨架变形有关，而且受到孔隙流体的影响。

A meso mechanical analysis has been conducted on a hot-rolling steel of 16MnR toinvestigate the effect of the elongated pre-damage voids on the subsequent damage evolution and fracture process under the maximum normal stresses with various directions. The analysis results show that, when the elongated voids due to the decohesion of the inclusions from base material are loaded subsequently, the local high stress and strain concentration around the voids and their interactions promote the growth of voids.

对热轧钢中的长条形初始损伤孔洞承受不同方向最大正应力时的后续损伤演化和断裂过程的细观有限元力学分析研究表明：热轧钢中的长条形夹杂物与基体剥离后形成的长条形孔洞在后续加载中，其周围产生的局部高应力应变集中及其相互作用，使孔洞长大。

It can decompound omethoate with high efficiency and even survive under 3g/L omethoate. The degradation was related to the trend of the growth of the strain dynamically.

通过对NWB-36有机磷农药降解特性的研究，结果表明，该菌对有机磷农药的降解具有遗传稳定性、广谱性和高效性，可耐受3g/L的氧化乐果，降解呈现动态变化，与菌体的生长趋势呈现一定的相关性。

Based on stress analysis , the forming mechanism of Uneven Horizontal Plastic Strain defect and its relation with production parameters has been researched in details.

从受力分析入手，研究了横折缺陷的产生机理及生产因素与其对应关系，精轧板形不良引起残余应力不均是开卷出现横折的主要原因。

The theoretical calculations for the mid-span deflection and bottom plate strain of the steel girder are found to be in good agreement with the experimental results. This indicates that the model established and the governing differential equations derived in this dissertation are correct and efficient.

论文中所提出的预应力简支钢箱梁理论的分析方法，对解决配置有曲线型预应力钢索的钢梁的非线性问题来说是一种精确而简便的计算方法。

Yet for thickness shear actuators, due to the shear deformation dominates the plate deflection for shear actuation mechanism, the higher order shear theory can provide more accurate evaluation of the shear strain energy of the plate than the first-order o

但对于厚度剪切型激励器而言，由于激励器主要是引起板的剪切变形，而高阶剪切变形理论比一阶剪切变形理论能更好地反映结构的剪切应变能，因此高阶剪切变形理论可以提供板变形的更为精确的解。

Deformation modulus: the ratio of the vertical load to the vertical strain is called as Deformation modulus.

土的变形模量：土体在无侧向约束条件下，竖向应力与竖向应变的比值。

The labia have now been sutured together almost completely.The drains and the Foley catheter come out at the top.

此刻阴唇已经几乎完全的缝在一起了，排除多余淤血体液的管子和Foley导管从顶端冒出来。

To get the business done, I suggest we split the difference in price.

为了做成这笔生意，我建议我们在价格上大家各让一半。