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The results (Fig. 1) show that the capability for producing monacolin K by Strain M12-69 initialized from Strain M12, is almost 9 times higher than that of Strain M12, whereas the citrinin concentrations produced by both strains remained at the lower levels.

结果(图1 )显示,有能力生产莫纳可林K的应变的M12 - 69初始化从应变的M12 ,是近9倍以上应变的M12 ,而所产生桔霉素浓度均株仍处于较低水平。

Based on definitions of stress and strain, and the D'Alembert's principle, stress and strain of soils at various depths were derived from the data of acceleration, displacement, as well as excess pore pressure measured in the test. The stress paths and stress-strain relationships of saturated sand during the shaking event, and their connection with development of excess pore pressure were revealed.

根据应力和应变的定义以及达朗贝尔原理,由试验观测的土体加速度、位移和孔隙水压力数据直接推导得到不同深度处砂土的应力和应变,揭示了振动过程中饱和砂土的应力路径和应力-应变关系演化过程,以及与超静孔隙水压力发展的联系。

As showed above, we could draw the conclusion that H3 viruses could cause outbreaks or local epidemics in Shanghai for the immune of population to the new emerging antigenic drift was still unknown though there was strong immune barrier to the previous vaccine strain, H1 viruses also may caused epidemics as the population had a weak immune protection to the previous reference strains A/New Caledonia/20/99-like and part of the recent isolates were distingwishing from them and continued to evolute on the new reference strain, and H5N1 HPAI activities has expanded its geographical range thus increasing the size of the population at risk as the continuing emergence of human cases which give the virus an opportunity to evolve towards a fully transmissible pandemic strain. We should keep eyes on the human cases of avian influenza virus an its variation for the H5 isolates in Shanghai also has the possibility to infect human directly and the infection of H5, H9 viruses had previously occurred in the population especially in those contacting with animals.

综合上述分析结果,我们认为上海地区人群虽然对原有的H3亚型参考病毒株有较高的免疫保护,但H3亚型病毒HA已出现新的抗原漂移,人群现在对新变异株的保护水平尚未知,有可能在未来引起局限性暴发甚至地方性流行;人群对H1亚型流感病毒免疫保护水平低,同时H1亚型流感病毒株部分与原推荐疫苗株抗原性差别较大,并在现推荐疫苗株基础上继续变异,需警惕发生流行的可能性;H5N1亚型高致病性禽流感地域范围扩大,人间病例不断发生,存在演变成大流行株的威胁,上海市H5亚型禽流感病毒株存在跨宿主屏障感染人类的可能性,而且已发现人群尤其禽、畜类动物接触人群中存在H5、H9亚型流感病毒的既往感染,应警惕禽流感病毒的变异和人间病例的发生。

Analysis of the strain field discovers that the principal compressive and the principal tensile strain rates in the epicenter area are -30.840×10-9/a and 13.956×10-9/a respectively before earthquake, and the principal compressive strain axis is in a direction of N105.4°E which is consistent with the average direction at N107.5°E of the principal compressive stress axis from focal mechanism result.

应变场分析发现,震前震中区的主压与主张应变率分别为-30.840×10-9/a与13.956×10-9/a,主压应变轴N105.4°E与震源机制解得到的主压应力轴的方向N103°E一致。

The fatigue is analyzed for the SENT specimen of TA6V titanium alloy at different stress ratio and on different stress level by the general finite element analysis software ANSYS. The dangerous fatigue location is predicted by the nodal stress Y-direction of the hemicycle notch for TA6V titanium alloy SENT specimen. Based on the local stress-strain method and the material S-N graph, the nominal stress-strain of the specimen is converted to the local stress-strain of the dangerous location by the elastic and plastic finite element analysis, thus the fatigue life is estimated by Miner fatigue damage accumulation theory and compared with the fatigue test of small crack growth.

借助大型通用有限元分析软件ANSYS对TA6V钛合金SENT试样在不同应力比和不同应力水平下进行疲劳分析,根据SENT试样缺口处的应力状态分布预测疲劳危险部位,采用局部应力应变法,结合材料循环的S-N曲线,通过弹塑性有限元法将构件上的名义应力谱转换成危险部位的局部应力应变谱,从而根据危险部位的局部应力应变历程采用Miner累积损伤理论对构件的疲劳寿命进行估算,并与疲劳小裂纹试验数据进行比较分析。

Under the condition of small strain, anisotropy is shown; however, the anisotropy degree decreases with the increase of shear strain, and the approximately isotropy is got. At the same time, the effect of stress path circumgyration on shear modulus decreases gradually along with the increase of shear strain.

在小应变条件下,土体表现出各向异性,但随剪切应变的增加而逐渐减小,最终表示为近似各向同性;同时由应力路径旋转对模量的影响也随着剪切应变的增加而逐渐衰减。

Simulate the condition of temperature and energy control in percutanous MWA for HCC to ablate SMMC-7721 cell strain suspension.There were five experiment groups:A.control group,B.45℃10 min group,C.50℃3min group,D.54℃3min group and E.60℃instant group.Detection for apoptosis was performed at 30 minutes and 2 hours after ablation.2.Thirty-two C57 mice were undertaken hypodermic inoculation of Hepal-6 tumor piece at right groin as ablation tumor and at left groin as observation tumor one week later.The mice with double tumors were separated into four groups:A.control group with no treatment,B.MWA group treated with MWA only,C.mDC group treated with MWA and subcutaneous injection of mature dendritic cells sensitized by neoantigen of Hepal-6 cell strain,D.iDC group treated with MWA and peritumoral injection of immature dendritic cells without neoantigen sensitization.

模拟肝癌微波治疗中常用消融区边缘的温控和能量条件,消融人肝细胞癌株SMMC-7721细胞悬液,分为五组:A、对照组,B、45℃10min组,C、50℃3min组,D、54℃3min组,E、60℃即刻组,消融后30分钟及2小时进行凋亡检测。2.32只C57小鼠左侧腹股沟皮下接种Hepa1-6鼠肝癌细胞瘤块作为消融瘤,间隔1周,右侧腹股沟皮下接种瘤块作为观察瘤,成瘤后分为四组:A组,对照组,不行治疗;B组,微波组,仅微波消融小鼠消融瘤;C组,成熟DC组,微波消融小鼠消融瘤,并于小鼠双侧腋下注射肿瘤抗原致敏的树突状细胞;D组,未成熟DC组,微波消融小鼠消融瘤,并于消融瘤周注射未成熟树突状细胞。

The invention relates to a new strain producing taxol and a taxol preparation method. The taxol is a diterpenoid alkaloid drug which is extracted from taxaceae plants and has a plurality of anti-tumor effects. Taxus, also known as yew, is a prehistoric plant with a history of 0.2 billion years and is a rare plant species with low growing speed; the biological characteristics of the taxus have high demand on the ecological environment; the natural renewal ability is poor, so the amount of the species is very limited, belonging to an endangered protection plant with limited resource, thus, scientists at home and abroad actively research and develop new taxol sources. The new strain for producing the taxol of the invention is the strain which is first separated from the bark of T.cuspidate Sieb.

产紫杉醇的新菌种及其选育和制备紫杉醇的方法,紫杉醇是从红豆杉属植物中提取出来的具有多种抗肿瘤疗效的二萜生物碱类药物,由于红豆杉,又名紫杉,是两亿年前的史前植物,是珍稀树种,生长速度缓慢,并且其生物学特性对生态环境要求较高,天然更新能力差,所以种群数量极为有限,属濒危保护植物,资源十分有限,因此,国内外学者都在积极地研究开发紫杉醇的新药源,本发明产紫杉醇的新菌种,所述的新菌种为从东北红豆杉T.cuspidate Sieb。

The Evolutional manners and dimensional rules of γmatrix and γ'precipitates in the [001], [110] and [111] oriented specimens of nickel-base single crystal superalloy CMSX-4 during the tensile creep at 1253 K and 350 MPa were studied.The effects of the change in characteristic dimensions of γand γ' phases on the strain and strain rate were compared for the differently oriented single crystal specimens.It was found that the effect of change in mean width of γchannels along the direction of directional coarsening of γ' precipitates(the lamella spacings between adjacent rafted γ'precipitates)on the strain and strain rate is remarkable.

研究了1253K,350MPa拉伸蠕变过程中[001],[110]和[111]取向镍基单晶高温合金CMSX-4基体相γ和析出相γ'的演变方式及相尺寸的变化规律比较了不同取向单晶试样中γ和γ'特征尺寸的变化对蠕变应变量和应变速率的影响结果表明,沿γ'定向粗化方向上γ基体通道宽度的变化速率对蠕变应变量和应变速率的影响较为明显。

The results show that the formation of the shear band is characterized with both strain localization and the localization of the averaged pure rotation ratio. The shear band starts right at the point where the volume strain changes from shrinkage to expansion. The development of these variables are significantly different within or outside of the shear band. Particularly, the stress-strain softening relationship was observed near or within the shear band, while the hysteretic phenomenon takes place outside the shear band. In addition, both the volumetric and deviatoric strains are larger inside than outside the shear band, with the soil being looser in the shear band.

研究表明:砂土剪切带的形成过程即为试样内部应变局部化过程,也为试样内部平均转动率(averaged pure rotation rate, APR)的局部化;剪切带开始形成点也为试样剪缩、剪胀分界点;剪切带内外各宏微观参数变化规律上存在明显的差异,主要表现为近剪切带位置土体及带内土表现为应变软化现象,而距带中心较远土体应力应变关系曲线出现'回滞圈'现象;带内变形量明显大于带外,且带内较带外松散。

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The split between the two groups can hardly be papered over.

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