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Results are as followed:1 Exposure of HELF cells to BP caused c-Jun activation,and increased the activity of MAPK,PI-3K,p53 and cyclin D1 pathway.2 BP-induced c-Jun activation was inhibited by dominant negative mutants of extracellular signal-regulated protein kinase or c-Jun NH_2-terminal kinase,but not by p38,impling that JNK and ERK pathways medicate c-Jun activation induced by BP.3 Overexpression of dominant-negative mutants PI-3K and Akt potently blocked phosphorylations of c-Jun and ERK,but not JNK in response to BP,suggesting that PI-3K/Akt pathway positively regulates BP-induced c-Jun activation through ERK.4 Inhibition of p53 by its chemical or molecular inhibitor markedly increased the phosphorylation levels of c-Jun,Akt and ERK upon BP stimulation,indicating that p53 negatively medicates BP-induced c-Jun activation through PI-3K/Akt/ERK pathway.5 The cell lines expressed TAM67 exhibits no significant affecting normal cell growth properties.6 TAM67 was able to significantly block G_1-S transition and subsequent cell proliferation,suggesting that c-Jun is essential for cell cycle alternations elicited by BP.7 Overexpression of TAM67 impaired BP-induced cyclin D1 activation,decreasing expression of E2F1 and pRb,indicating that c-Jun participates in the modulation of BP-induced activation of cyclin D1/pRb/E2F1 pathway.8 Stably expression of TAM67 led to the increases in the expression levels of p53 and p21,elevating phosphorylation level of p53,clearly indicating that c-Jun regulates p53/p21 pathway activation induced by BRCollectively,PI3K/Akt/ERK pathway mediated BP-induced c-Jun activation through p53-dependent mechanism.

结果显示：1BP刺激细胞可促进c-Jun活化，并伴随着MAPK、PI-3K、p53和cyclinD1通路各组成成分的活性增强。2利用MAPK通路的显性失活突变体分别阻断细胞外信号调节激酶和c-Jun氨基末端激酶活性，均可明显抑制BP诱导的c-Jun活化，但阻断p38活性对BP引起的c-Jun活化无明显影响，提示JNK和ERK通路参与调控BP诱导的c-Jun活化。3过表达PI-3K和Akt的显性失活突变体也可显著抑制BP诱导的c-Jun活化，并降低磷酸化ERK的表达水平，但对磷酸化JNK的表达水平无明显影响，说明PI-3K/Akt通路通过ERK正性调控了BP诱导的c-Jun活化。4p53的化学/分子抑制剂能使BP作用的细胞内c-Jun活性明显增加，并同时诱导Akt和ERK的磷酸化水平的升高，表明p53可通过PI-3K/Akt/ERK通路对BP诱导的c-Jun活化进行负性调控。5随后观察转染细胞的生长情况，发现TAM67对细胞正常生长和形态无明显影响。6稳定表达TAM67可有效抑制BP诱导的S期细胞数的增加，提示c-Jun在BP致细胞周期改变的过程中发挥了重要作用。7TAM67过表达能够抑制BP诱导的cyclin D1活化，降低磷酸化Rb以及E2F1蛋白表达水平，表明c-Jun参与调控BP诱导的cyclin D1/Rb/E2F1通路的活化。8过表达TAM67可使BP刺激的细胞中p53、p21总蛋白以及p53磷酸化的表达水平明显升高，可见c-Jun也参与调控BP诱导的p53/p21通路活化。

After hears the yellow Jinlong commander in chief's order, already succeeded the hook to live this planetoid the starships, after passed through the very short time, had achieved with the planetoid the similar speed, likely the human rode in the acceleration the airship to be same, starts the anchor chain which back and forth vibrated this time already to pull taut, and started to maintain stably, all starship pilot, already not in the worry planetoid surface more than 1200 degrees high temperatures, the thick fog group which as well as raided intermittently, after received the order then the rapid start automatic hinge machine, to this planetoid superficial fast advancement, in order to set aside the enough debarkation space for the second interspace group,This time by far looks, the entire starry sky scene, looks like a big spider to lead only to creep along innumerably small spider such, has filled the mysterious visual effect, lets the human feel incomparably shocks!

在听到黄金龙总指挥官的命令后，已经成功钩住这颗小行星的星际飞行器们，在经过很短的时间后，就与小行星达到了同样的速度，就像人乘坐加速中的飞船一样，开始来回抖动的锚链此时已经绷紧，并开始保持稳定，所有星际飞行器的驾驶员，已经不在顾虑小行星表面1200多度的高温，以及阵阵袭来的浓雾团，接到命令后便迅速启动自动铰链机，向这颗小行星的表面快速推进，以便给第二星际小组腾出足够的登陆空间来，此时远远望去，整个星空场面，就像一只大蜘蛛带领着无数只正在爬动中的小蜘蛛那样，充满了神奇的视觉效果，让人感到无比震撼！

It is a customized device for the process of bolts fastening on the starter motor shells to ensure the equal tightening force on the different interpole bolts. Driven by the oil motor, it runs stably and safely.

该设备系起动机外壳紧螺钉工序的专用设备，保证起动机外壳各磁极螺钉的扭紧力相同；采用油马达驱动方式，转动平稳安全可靠。

Intrafascicular microelectrodes can stably record the electrical signals of cardiac sympathetic nerve.

神经束内微电极可稳定记录心交感神经电信号，能较好反映神经束内电活动的变化。

Only one cell line named OHe which could secrete McAb stably was obtained.The isotype of the McAb was IgGi,the average number of chromossme of the hybridoma cell line was 97 respectively.

经鉴定该单抗为IgG_1亚类，杂交瘤细胞的平均染色体数目为97条，杂交瘤细胞培养上清及小鼠腹水单克隆抗体的ELISA效价分别为1：1024和

This article is divided into three parts: The first part elaborated the connotation of political culture in the new countryside, at first the political culture is one kind of internal social politics consciousness, is one kind of invisible strength, it may instruct political behavior of the main body profoundly, stably, lastingly.

本文共分三个部分：论文第一部分论述了新农村政治文化的内涵，政治文化首先是一种内在于心的社会政治意识，是一种无形的力量，可以深刻、稳定、持久地指导政治行为主体的政治行为。

Magnetism Msier is operated easily,non scale changes speed,can mix liquid precisely and stably in mide speed range,especially fit little samples experiments.

磁力搅拌器操作简便，无级调速，能在较广的速度范围内对液体溶液进行精密稳定的搅拌，特别适合小体积样品的试验。

Production of hepatitis B virus by stably transfected monocytic cell line U-937:A model for extrahepatic hepatitis B virus regulation.

乙型肝炎病毒性功能基因组在转基因小鼠体内的表达和复制。

Both DO and ORP are used as fuzzy control parameters of SBR1 aerobic duration, which can maintain heterotrophs for organics removal and Nitrosomonas in different reactors and make TSSBR system operate stably and reliably.

将DO和ORP联合作为SBR1阶段好氧反应时间的模糊控制参数，可使去除有机物的异养菌和硝化菌存在于不同的反应器内，保证两段SBR系统长期稳定运行。

The adhesive capacity of differentiated cells that stably expressed E-cadherin was markedly enhanced. Compact cell connection and multi-layer growth state remained at 19 days. While non-transfected ESCs gradually changed from embryoid bodies into noncohesive cell populations.

稳定表达上皮型钙粘蛋白的分化细胞间黏附能力明显增强，并在19 d时仍能保持致密的细胞连接和多层生长状态，普通胚胎干细胞则由拟胚体结构逐渐分化为松散的细胞群落。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。