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The mechanisms of apoptosis of skin squamous cell carcinoma induced by IFN-γand ATRA Introduction and objective Skin squamous cell carcinoma is a malignant neoplasm derived from epidermal keratinocyte and squamous cells of skin appendant organ .It is one of the most common skin carcinoma, and the incidence rate of SCC is 20% in malignant non-melanoma. It is a common disease that seriously harms health of people in our country, so we should pay more attention to it.

维甲酸、γ-干扰素诱导皮肤鳞状细胞癌SCL-1细胞凋亡的机制研究前言与目的皮肤鳞状细胞癌(squamous cell carcinoma，SCC，简称鳞癌)是起源于表皮角质形成细胞或附属器鳞状上皮细胞的一种恶性肿瘤，是常见的皮肤恶性肿瘤之一，其发病率约占全部非黑素细胞癌的20％。

The mechanisms of apoptosis of skin squamous cell carcinoma induced by IFN-γand ATRA Introduction and objective Skin squamous cell carcinoma is a malignant neoplasm derived from epidermal keratinocyte and squamous cells of skin appendant organ .

维甲酸、γ-干扰素诱导皮肤鳞状细胞癌 SCL-1细胞凋亡的机制研究前言与目的皮肤鳞状细胞癌(squamous cell carcinoma，SCC，简称鳞癌)是起源于表皮角质形成细胞或附属器鳞状上皮细胞的一种恶性肿瘤，是常见的皮肤恶性肿瘤之一，其发病率约占全部非黑素细胞癌的20％。

Conventional esophago gastro duodenoscopy can disclose a lesion only when it presents as a protuberant mass, an ulceration or when there is significant discoloration. When an early esophageal squamous cell carcinoma or dysplasia, frequently lacking such changes, is confronted, conventional endoscopy usually fails to detect it.

传统消化道内视镜只能发现有突出肿块、溃疡或明显黏膜颜色改变的进行性食道癌病徵，对於无上述变化与症状的早期食道鳞状细胞癌(squamous cell carcinoma， SCC)则不容易以传统内视镜的检查方法诊断。

The cells at the edge of the basaloid islands tended to show palisading arrangement. Squamous epithelium on the surface of tumor often accompanied with carcinoma in situ or superficial invasive squamous cell carcinoma. Occasionally cancer nets were connected with basement layer of squamous epithelium laying in the surface, and rare squamous cells or glandlike structures were seen in the cancer nests.

但BSC癌细胞分化较低异型性较强，癌巢周围细胞呈栅栏状排列，肿瘤表面鳞状上皮常伴发原位癌或浅表浸润性鳞状细胞癌；偶见癌巢与表面鳞状上皮基底层相连、或偶见癌巢内形成鳞状细胞，或腺管样结构，这些与ACC不同。

Results Although overexpression of P53 protein was not detected in normal eyelid cutaneous epithelium, meibomian gland and mild epithelial dysplasia, the positive rate of P53 increased in degree in moderate and severe dysplasia, carcinoma in situ and invasive tumors, and PCNA labeling index progressively increased too. Overexpression of P53 protein was detected in 30/53 cases of basal cell carcinoma, 16/32 cases of squamous cell carcinoma, 10/17 cases of meibomian gland carcinoma, and the intensity of P53 protein immunostaining increased with the lowering in the degree of histological differentiation.

结果 在正常眼睑皮肤、睑板腺及轻度不典型增生眼睑上皮中，未见P53蛋白表达，而中、重度不典型增生，原位癌，浸润癌中，P53蛋白阳性表达率逐渐增高，其 PCNA指数也有增加趋势。30/53例基底细胞癌(basal cell carcinoma，BCC)、16/32例鳞状细胞癌（squamous cell carcinoma，SCC）、10/17例睑板腺癌中，P53蛋白阳性表达；同时，随着肿瘤组织分化程度的降低，P53蛋白阳性表达程度有逐渐增高的趋势。

In normal postauricular skin, EGF was expressed in squamous epithelium in 14 samples (41%), fibroblasts in one sample (3%), and endothelium in none. No statistical difference in EGF expression was found between cholesteatoma and normal postauricular skin samples.

在中耳胆脂瘤组织细胞中，EGF阳性百分比在squamous epithelium、endothelium及fibroblast细胞分别为53%（21例）、5%（2例）及5%（2例）；而在耳廓后皮肤组织中，其阳性率分别为41%（14例）、0%（0例）及3%（1例）。

RESULTS The positive rate of P-gp170expression in cervi-cal cancer pre-radiotherapy was58%（22/38）.Among them,the positive expression rates were10/18（56%）,6/10,4/6and2/4in keratinizing,nonkeratinizing squamous-cell carci-noma,adenocarcinoma and adeno-squamous-cell carcinoma respectively.The positive rate of post-radiotherapy was90%（34/38）and among them,the positive expression rates were16/18（89%）,8/10,6/6and4/4in keratinizing,nonkera-tinizing squamous-cell carcinoma,adenocarcinoma and adeno-squamous-cell carcinoma respectively.

结果 宫颈癌组织P-gp170阳性表达在放疗前为58%（22/38），其中角化型、非角化型鳞癌、腺癌及腺鳞癌分别为10/18（56%），6/10，4/6，2/4例；放疗后其P-gp170阳性表达为90%（34/38），其中角化型、非角化型鳞癌、腺癌及腺鳞癌分别为16/18（89%），8/10，6/6，4/4例，P-gp170表达阳性强度较放疗前亦呈增高趋势。

Objective To establish human oral squamous cell carcinoma cell line ,to ascertain its origin of tissue,and research curcumine's correlated toxicant effect toward squamous cell, to detect a series of bionomics after applying curcumine,such as cell morphous ,growth cycle,the expression of nuclear factor and cyclin .

研究目的旨在建立人类口腔鳞状细胞癌(oral squamous cell carcinoma，0SCC )细胞系，确定其组织来源，并研究姜黄素对鳞癌细胞的相关毒性作用，对作用后的细胞形态、生长周期、核转录因子蛋白及细胞周期蛋白的表达等进行一系列生物学特性检测。

Objective: To investigate the expression of MAGEA1 and MAGEA3 protein in the development of head and neck squamous cell carcinoma, as well as in the head and neck squamous cell carcinoma and adjacent tissues. It will help to know the correlation of the two proteins in head and neck squamous cell and provide satisfactory and safe surgical margin of squamous cell carcinoma.

目的：探讨MAGEA1及MAGEA3蛋白在头颈部鳞癌的发生过程中的表达以及在头颈部鳞癌及癌旁组织中的表达情况，了解其与头颈部鳞癌发生的相关性，并为鳞癌手术安全切缘的范围提供理论依据。

Results: The sex ratio of the ASIR for adenocarcinoma was lower than sex ratio of the ASIR for squamous cell carcinoma in 19 countries.

结果：19个国家肺腺癌（adenocarcinoma， AC）年龄标准化发生率性别比值相对於肺鳞状细胞癌（squamous cell cancer， SCC）年龄标准化发生率性别比值是较低的。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。