查询词典 splicing
- 与 splicing 相关的网络例句 [注：此内容来源于网络，仅供参考]
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To investigate the function of Nogo-A in neurons, human embryonic kidney cell line 293FT was used as a model, along with the pathway profiling reporter system to check the involvement of Nogo-A in regulating the intracellular signaling pathway. It was found that over-expression of Nogo-A could activate NF-κB signaling specifically, then followed by using different Nogo-A alternative splicing isoforms and a serial of truncations, it was confirmed that the activation of NF-κB by Nogo-A relied on its N-terminal proline rich domain. Furthermore, by co-expressing the dominant negative mutants of some NF-κB pathway associated proteins, it revealed that the IκBα,TRAF6, Rac/Cdc42 were involved in Nogo-A inducing activation of NF-κB.
为探讨神经元内Nogo-A的功能，以HEK293FT细胞为模型，利用信号途径报告基因系统筛选过表达Nogo-A对多种信号途径的调控作用，发现过表达Nogo-A能特异激活NF-κB信号，利用不同的Nogo-A剪接体和截断体形式研究，证明Nogo-A激活NF-κB信号依赖于其氨基端的proline rich结构域，进一步使用NF-κB信号途径相关分子显性突变体揭示IκBα、TRAF6、 Rac/Cdc42 参与Nogo-A激活NF-κB信号。
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To investigate the function of Nogo-A in neurons, human embryonic kidney cell line 293FT was used as a model, along with the pathway profiling reporter system to check the involvement of Nogo-A in regulating the intracellular signaling pathway. It was found that over-expression of Nogo-A could activate NF-KB signaling specifically, then followed by using different Nogo-A alternative splicing isoforms and a serial of truncations, it was confirmed that the activation of NF-kB by Nogo-A relied on its N-terminal proline rich domain. Furthermore, by co-expressing the dominant negative mutants of some NF-kB pathway associated proteins, it revealed that the IkBα,TRAF6, Rac/Cdc42 were involved in Nogo-A inducing activation of NF-kB.
为探讨神经元内Nogo-A的功能，以HEK293FT细胞为模型，利用信号途径报告基因系统筛选过表达Nogo-A对多种信号途径的调控作用，发现过表达Nogo-A能特异激活NF-kB信号，利用不同的Nogo-A剪接体和截断体形式研究，证明Nogo-A激活NF-kB信号依赖于其氨基端的proline rich结构域，进一步使用NF-KB信号途径相关分子显性突变体揭示IkBα、TRAF6、Rac/Cdc42参与Nogo-A激活NF-kB信号。
- 推荐网络例句
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As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.
每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。
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Maybe they'll disappear into a pothole.
也许他们将在壶穴里消失
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But because of its youthful corporate culture—most people are hustled out of the door in their mid-40s—it had no one to send.
但是因为该公司年轻的企业文化——大多数员工在40来岁的时候都被请出公司——一时间没有好的人选。