查询词典 sphingosine

Sphingosine 1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring .

上述研究成果显示Bcl-2基因家族成员在卵泡凋亡调控中发挥重要作用，Bcl-2/Bax的比例决定卵泡是否接受诱导凋亡的信号。

The strategy of building the syn-anti chiral vicinal diolmoiety of sphingosine intermediate and the synthetic studies of anti-fungal antibioticssphingofungin using sugar as chiral pool are also described.

这些物质生理作用极强，但在机体中储存量极少、结构具有高度不均一性、生物和化学稳定性又差，它们的化学合成具有十分重要的理论和应用意义。

In our islet transplantation program nonhuman primates with STZ-induced diabetes received transplants under chronic immunosuppression including calcineurin inhibitors, drugs in the rapamycin class affecting growth factor-induced cell proliferation, and the sphingosine 1-phosphate receptor antagonist FTY720. Four animals developed renal failure and had to be sacrificed, most likely caused by cyclosporine.

在我们应用STZ诱导的糖尿病的灵长类动物性胰岛细胞移植的病例长期应用的免疫抑制剂包括：钙神经素拮抗剂，雷帕霉素和神经鞘氨醇1－磷酸盐FTY720.4个动物死于肾功能衰竭，这很可能是由于环孢素引起的。

Background— Numerous in itro studies suggest that sphingosine 1-phosphate (S1P), a bioactie lysosphingolipid associated with high-density lipoproteins, accounts at least partly for the potent antiinflammatory properties of high-density lipoprotein and, thereby, contributes to the antiatherogenic potential attributed to high-density lipoproteins.

背景——众多的活体研究表明鞘氨醇1-磷酸盐作为一种与高密度脂蛋白相关的生物活性溶血磷脂，至少是高密度脂蛋白有力抗炎特质的部分原因，从而促成高密度脂蛋白的抗动脉粥样硬化潜能。

These small molecules include FTY720, a sphingosine phosphate-receptor modulator, FK778, an inhibitor of pyrimidine synthesis, CP-690550, a JAK3 inhibitor, and AEB-071, a protein kinase C inhibitor.

这些小分子包括FTY720，一种神经鞘氨醇磷酸盐受体调节剂；FK778，一种嘧啶合成抑制剂；CP-690550，一种JAK3抑制剂及AEB-071，一种蛋白激酶C抑制剂。

During these years (1997-2000) in the research area of annonaceous acetogenins 5 natural products and a number of chiral-pure analogs of annonaceous acetogenins have been synthesized using sugars as the starting materials. Their high activity and selectivity against cell line of colon tumor and a relationship between activity and configuration have been found too. In the respect of inhibitor of sialidase two new methodologies for the synthesis of chiral-pure 3-deoxy-ulosonic acid using hetero-Diels-Alder reaction or asymmetric propargylation as the key reaction were developed. On the topic of anti-leukemia marine natural product clavulactone a synthetic method based on the free radical cyclization and starting from sugar has been developed. In other title of PKC inhibited agent sphingosine a new synthetic route with SN2' as the key reaction has also been disclosed.

项目期间（1997-2000）在番荔枝内酯方面从糖出发合成了五个天然产物和一批手性纯的类似物，它们对肠癌细胞有很高的活性和选择性，并与构型有关；在唾液酸酶抑制剂方面发展了二类全新手性纯高碳糖的合成方法－杂原子D－A反应或丙炔基不对称加成为关键的反应；抗白血病海洋天然产物群柱虫内酯方面研究了由糖出发和自由基环化反应的合成方法；对PKC 起抑制作用的鞘氨醇方面也开创了新的合成途径－由糖出发并以SN2'反应为关键反应。

Further study indicated that HI117 and SJ9A4-induced Fg binding was reduced by pretreatment of platelets with sphingosine, aspirin, apyrase, and/or PGI2. Conclusion The anti-CD9 McAbs, HI117 and SJ9A4, can reversibly expose platelet Fg receptors, probably via three signaling pathways, i.e.

HI117和SJ9A4均能诱发血小板膜Fg受体暴露，两者诱发人血小板Fg受体暴露可能是三条途径综合作用的结果：即二磷酸腺苷释放、血栓烷生成和环磷酸腺苷途径，而PKC激活可能是三条途径的共同通路。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。