查询词典 spermatogenic

A significant decrease in BOULE transcript levels was detected in patients with spermatogenic failure, and BOULE transcript levels progressively decreased with increasing severity of testicular failure.

研究结果显示在造精障碍的患者中 BOULE 转录量显著的降低，而且随著造精障碍的严重程度增加，BOULE 转录量就更显著的下降。

Objective:To study the molecular mechanism of cadmium chloride on the damage of spermatogenic cell damage.

目的：研究镉暴露对雄性小鼠精子生成的影响及其分子机制。

Results showed that TDI induced toxic action on spermatogenic cell,while the chondriosome was its target within the length and concentrations.

结果表明：在本实验染毒时间和染毒剂量范围内，TD I对雄性的生殖毒性主要表现为对各级生精细胞均有一定的毒性作用，作用的靶点是细胞内的线粒体；TD I通过影响各种酶的活性，干扰了睾丸组织的有氧代谢和无氧供能，抑制了细胞对能量的利用，损伤了各级生精细胞，导致生精上皮不可逆的损害，从而造成了其对雄性生殖系统的损伤；TD I对雄性生殖细胞的核酸代谢以及DNA合成有一定影响。

Sertoli cells can provide a material basis and a favorable microenvironment for sperm. After X radiation, spermatogenic cells and mitochondrion dramatically swelling and lysis with a decrease of mitochondrial cristae, with the prolonging of time, the mitochondria damage get even worse, mitochondrial crista is disappeared.

Sertoli细胞在精子发生过程中可为精子发生提供物质基础和能力，为精子发生提供有利的微环境，对精子的生成有复杂的作用。X射线照射后即出现生精细胞和支持细胞线粒体明显肿胀，线粒体嵴减少，且随着时间延长，线粒体形态的损害进一步加重，线粒体数量减少，线粒体嵴消失。

Due to the deficiency of cyclin B1 and 〓, spermatogonia and pachytene/diplotene primary spermatocytes in contralateral cryptorchid testis were unable to form MPF, and therefore, they could not accomplish their nuclear division, and became arrested at the transition stage from mitosis to meiosis (G2/M phase). We also found that testosterone could regulate the cyclin B1 expression in spermatogenic cells.

由于cyclin B1和〓的缺失，粗线期/双线期初级精母细胞中的MPF无望形成，从而导致生精细胞分裂停滞在由有丝分裂向减数分裂过渡的G2/M相；（5）睾酮可在翻译水平上调控阴囊内睾丸生精细胞cyclin B1蛋白的表达。

Results Administration of L-NAME could attenuate the activity of NOS and inhibit spermatogenic cells apoptosis in rats experimental cryptorchidism, and it could significantly inhibit weight loss of the cryptorchid.

手术建立大鼠单侧隐睾模型，实验分为隐睾组、隐睾+L-NAME组［术后腹腔注射溶于生理盐水的L-NAME 50 mg/(kg\5d)］、隐睾+生理盐水组、假手术组，7 d后采用化学比色法检测睾丸组织NOS活性，流式细胞术和原位缺口末端标记法检测生精细胞凋亡，RT-PCR和免疫组织化学法检测Bax基因表达变化。

To investigate whether the expression of cdc2 and cyclin B1 in spermatogenic cells during spermatogenesis is actually a temperature dependent event, in situ hybridization, Western blotting and immunohistochemistry analysis were used to study the expression of cdc2 and cyclin B1 in normal and cryptorchid testis. Results showed that heat would differentially hurt male germ cells in different developmental stages during spermatogenesis, especially the pachytene primary spermatocytes. Most of spermatogonia in contralateral cryptorchid testis were not harmed fatally by heat as yet, indicating that spermatogonia could resist to beat to a certain extent. In this case spermatogonia could develop to pachytene/diplotene primary spermatocytes, but they could not acquire the ability to complete the transition from mitosis to meiosis, and then appeared to go through apoptosis. Therefore, we could not find the descendants of meiosis: secondary spermatocytes and round spermatids, elongated spermatids and spermatozoon. The abdominal temperature had no significant influence on the transcription of cdc2 and cyclin B1 in the spermatogonia and pachytene/diplotene primary spermatocytes. In normal rabbit testis, cyclin B1 increased in the pachytene/diplotene primary spermatocytes before meiosis and reached its peak in the spermatids.

为了解精子正常发生过程中cdc2和cyclin B1表达的低温依赖性，我们利用原位杂交和免疫组化等方法，研究了正常和隐睾精子发生过程中cdc2和cyclin B1的转录和翻译调控活动，结果表明：（1）热对各阶段的雄性生殖细胞都有损害，粗线期的初级精母细胞尤为敏感，实验性隐睾内的精原细胞尚未完全受到"致命"影响，说明精原细胞对热有一定的耐受性，但即使成为粗线期／双线期初级精母细胞，却未能获得由有丝分裂过渡到减数分裂的能力，呈现不同程度的凋亡，所以在整个切片中找不到源自减数分裂的产物----次级精母细胞、圆形精子细胞，更谈不上长形精子细胞和精子的形成；（2）腹腔高温未明显地影响隐睾精原细胞和粗线期/双线期初级精母细胞中cyclinB1和cdc2的转录，说明高温并不是通过影响cyclin B1和cdc2的转录活动而导致生精过程阻断的；（3）正常兔睾丸组织中，〓在精原细胞和粗线期／双线期精母细胞中均有表达：cyclin B1蛋白在减数分裂前期的粗线期／双线期初级精母细胞中的表达量增加，于变态末期的精子细胞中达高峰。

They existed as dosage-effect and time-effect. All of these results proved that Sertoli cell was the first target cell, spermatogenic cell was the second one and mitochondrion was the target. Otherwise, we proved this compound can disturb the development and growth of sperms, influence the activity and amount of sperms and increase the deformation ratio.

结合组织病理和性激素及酶活性的改变，揭示该化合物睾丸毒性的靶细胞是支持细胞，其次是生精细胞，作用的靶点是细胞内的线粒体，此外还证明该化合物干扰精子的生长和发育，影响精子的活力和数目，增加畸形率，是雄性精子畸变的诱导剂。

Results:compared with the torsion/orchiectomy group,the biochemical parameters and histological grades in the torsion/detorsion group increased in different degrees, and the prognosis status demonstrated by the number of spermatogenic cell associated with the decreased mean diameter of the seminiferous tubule, there are a worse prognoses in the torsion/detorsion group.

与扭转切除组比较，扭转复位组对侧睾丸的mda、il-6值、病理评分等均有不同程度升高，且1周时生精细胞层数结合精细小管直径所示的预后情况亦较差；而各指标在扭转切除组与假手术组的相比中未示明显差异。

Objective To study the effect of Pubertal exposure of male SD （Sprague-Dawley） rats to diethylstilbestrol on the apoptosis of spermatogenic cells after sexual maturation and its mechanism.

目的研究青春期己烯雌酚（diethylstilbestrol，DES）摄入对SD（Sprague-Dawley）大鼠性成熟后睾丸生精细胞凋亡的影响，并初步探讨其机制。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。