查询词典 speculate

We speculate that antisense p42 may affect the separation of replicated centrosome, thus results in the formation of monopolar spindle, and affact the happening of the cytokinesis of HAP42 cell.

推测反义p42可能特异地延迟或阻断联系中心体间某些蛋白的水解，影响了细胞已复制的中心粒的分离，形成了单极纺锤体。

Majority of acute leukemias in infant, either acute lymphoblastic leukemia or acute myeloblastic leukemia, posses a chromosomal translocation affecting the 11q23 chromosome region which specifically inoles the mixed-lineage leukemia gene.1-3 Most pediatric leukemias with MLL rearrangement clearly hae a remarkably short latency.1,4 MLL gene rearrangement is also associated with secondary leukemias of patients preiously treated with the topoisomerase II inhibitors.4 The latency of these secondary leukemias is similarly ery short.4 Of note, the concordance rate of leukemia with MLL rearrangement in infant monozygotic twins approximates to 100%,1,4 and identical breakpoint in the MLL gene was shared in these pairs of identical twin infants with concordant ALL.1,4 Moreoer, the unique and clonotypic MLL fusion gene was detectable in neonatal blood spots for Guthrie cards from non-twined indiiduals who subsequently deeloped ALL.1,4 These obserations indicate not only that MLL fusion is generated in utero but also that MLL fusion proteins could be capable of inducing leukemic transformation with few, if any, secondary mutations.2,3,4 Greaes et al speculate that an MLL fusion protein somehow promotes rapid transition to full-blown disease in patients ia ery rapid clonal expansion, genetic instability, or inhibition of DNA damage repair.4 In general, for clonal expansion of malignancies, tumor cells often hae acquired strategies that escape immune sureillance of the hosts.5,6 Immune escape mechanisms also contribute to the failure of graft-ersus-leukemia effect after allogeneic hematopoietic stem cell transplantation.7 Therefore, leukemia cells could acquire some immune escape mechanisms during leukemogenesis.

绪论 绝大多数的婴儿白血病，不管是急性淋巴性白血病或是急性骨髓性白血病，在染色体11q23部位有染色体易位的情况；这个部位的染色体易位牵连了混合谱系白血病基因。大多数具有MLL基因重排的儿童白血病潜伏期明显短很多。MLL基因重排也和经拓扑异构酶II抑制剂治疗后的继发性白血病有关。这些继发性白血病的潜伏期类似地都非常的短。很重要的是，单卵双胞胎婴儿同时患有或同时免于MLL基因重排阳性的白血病的一致性接近100%；并且同样患有ALL的同卵双胞胎的MLL基因的断裂点是一致的。而且，这种独特的克隆特异性的MLL融合基因能够从那些得ALL的非双生个体出生时的血斑标本中检测到。这些发现表明MLL融合基因产生在胎儿还在子宫的是后，而且MLL融合蛋白能过和其他的基因突变一起诱导白血病的产生。Greaes 等推测MLL融合蛋白在某种情况下同过快速克隆增殖，遗传的不稳定性或是DNA损伤修复的抑制促使疾病迅速地全面爆发。恶性肿瘤细胞的克隆增殖通常已经获得了逃避机体免疫监视的能力。免疫逃避机制也归因于异体外周血干细胞移植后移植物抗白血病作用的失效。所以，白血病细胞在白血病的产生过程中可能获得了某些免疫逃脱机制。

That is a small part of the biological history of man, and until we know far more about the neurophysiological aspects of language, we can only speculate about the origins of signs as symbols.

而这只是人类的生物学历史的一小部分，而且只有我们对语言的neurophysiological神经生理学方面了解得多得多时，我们才能推测信号作为象征/符号的起源。

We speculate that AEP2 and OLI1 have evolved during the adaptation of S. bayanus to nonfermentable carbon sources, thereby driving speciation.

这项成果对于未来医学应用有也帮助，可以持续观察粒线体扮演的角色，为癌症与老化方面的研究提供参考。

Polian wouldn't speculate on the Indianapolis lineup as the team prepares for the start of training camp July 29 in Terre Haute.

保连不用猜想小马的阵容，因为球队正为周日在特雷霍特进行的训练营准备首发名单。

Considering the function of CCT, we speculate that CCT may play an important role in these function of ZNC PR, such as memory-enhancing activity, facilitate neurite elongation and prolongate cell ageing.

这与ZNCPR受体结合点的分布一致，结合CCT所具有的功能，我们推测CCT可能使ZNCPR易化记忆的获得和保持，并在脑损伤的修复、易化神经轴突的延长和细胞老化的延缓中起到一定的作用。

Thus, we speculate that a certain proprioceptive deficit threshold must be reached before physical function is affected.

因此，我们推测某本体感受必须以前到达缺乏门限物理作用受影响。

Although he does not,' speculate further, it is clear that he believes there is, to be realistic, very little latitude in the forms of power and authority appropriate within modern sociotechnical systems.

虽然他没有进一步推断，但他相信这是很清楚的，很现实的，要符合於现代社会技术体系，除了权力与权威外，几乎再没有其他回旋的余地。

Some historians speculate that the shroud may have been found in Constantinople by the Knights Templar during the 12th or 13th century and subsequentially taken to France.

一些历史学家推测裹尸布会在十二或十三世纪期间被基督教圣堂武士在君士坦丁堡找到，后来送到了法国。

We speculate that this is due to the highly specific bindingof sufentanil to spinal and supraspinal receptors.

我们推测这是由于苏芬太尼与脊髓和脊髓上受体的高亲和力。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。