查询词典 sodium pump

A large quantity of evidence has showed that higher EO might be one of the pathogenic factors of hypertension. EO also referred to endogenous sodium pump inhibitor, endogenous digitalis-like substance or endogenous digoxin-like factor before, is a recently identified sterone hormone that might be secreted from adrenal cortex.

内源性哇巴因(endogenous ouabain， EO)是新近发现主要由肾上腺皮质所分泌的一种类固醇激素，大量证据表明，体内EO含量升高可能是高血压的发病因素之一。

Sodium pump and calcium pump in the human body plays an important role, and its vitality is the size of the various cell energy metabolism and function of an important indicator of whether the injury.

钠泵和钙泵在人体内起着非常重要的作用，其活力的大小是各种细胞能量代谢及功能有无损伤的重要指标。

Based on adequate survey to faults of sodium pump for The China Experiment Fast Reactor, in order that the advanced diagnosis methods are used in the sodium pump which is under fabrication, different methods of fault diagnosis system of sodium pump are designed and programmed; and the principal component analysis is used to fault diagnosis system of main coolant pump in a nuclear power station. The feasibility of fault diagnosis systems developed have been proved by simulation results.

本课题对中国实验快堆钠泵的故障进行了研究，把先进的珍断方法应用到正在制造中的钠泵上，设计和开发了不同方法的钠泵的故障诊断系统；同时也应用主元分析方法，建立了某核电厂的主冷却剂泵的故障诊断系统，仿真实验证明了以上三个系统的可行性。

Based on adequate survey to faults of sodium pump for The China Experiment Fast Reactor, in order that the advanced diagnosis methods are used in the sodium pump which is under fabrication, different methods of fault diagnosis system of sodium pump are designed and programmed; and the principal component analysisis used to fault diagnosis system of main coolant pump in a nuclear power station. The feasibility of fault diagnosis systems developed have been proved by simulation results.

本课题对中国实验快堆钠泵的故障进行了研究，把先进的诊断方法应用到正在制造中的钠泵上，设计和开发了不同方法的钠泵的故障诊断系统；同时也应用主元分析方法，建立了某核电厂的主冷却剂泵的故障诊断系统，仿真实验证明了以上三个系统的可行性。

Astragalus patients with coronary artery disease can significantly improve the function of red blood cell sodium pump to reduce intracellular sodium concentration, red blood cell function recovery on the one hand, on the other hand, is also conducive to the nutritional metabolism of myocardial cells.

黄芪还可明显提高冠心病病人红细胞钠泵的功能，使细胞内钠浓度降低，一方面可恢复红细胞功能，另一方面也有利于心肌细胞的营养代谢。

The wavelet packet analysis applied in fault diagnosis system is studied in this thesis. Using simulation fault data, uncalm and time difference vibration signal of sodium pump are decomposed on different levels and frequencies. To picked-up the eigenvectors reflecting different fault of sodium pump with availability, simulation results have shown its satisfaction in the identification.

对小波包分析应用于故障诊断进行了研究，利用仿真出来的故障数据，将快堆钠泵非平稳时变振动信号分解到不同层次和不同频带上，有效地提取出反映钠泵不同故障的特征向量，在识别中得到了满意的结果。

In group C, the level of intracellular calcium increased persistently and the peak value was at 2 hours post-CPB、The activity of calcium pump and sodium pump increased temporarily at the begining of CPB, the lowest value was at 2 hours post-CPB.

结果表明：对照组转流中红细胞钙持续升高，转流后2小时达高峰；钙、钠泵活性在转流开始一过性升高，此后下降，转流后2小时最低。

Change of sodium pump activity is involved in hypoxic injury in rat cortical neurons. High affinity sodium pump is re lated to the protection of hypoxic injury and low affinity sodium pump is related to the hypoxic injury.

Na，K-ATP酶活性改变参与了皮质神经元的缺氧性损伤，其中高汞和力Na，K-ATP酶与皮质神经元缺氧性损伤保护作用有关，而低亲和力Na，K-ATP酶则与其缺氧性损伤有关。

Each medicine used in the study totally has obivious effect on lens sodium-pump. Either on the molecular and cellular level or on the histological and organic level , they all have their distinctive demonstration. 1.Ouabain、Digoxine、DMSO decrease the expression of αsubunit of sodium pump on mRNA level , the cell morphology and ultramicroscopic structure demonstrated destructive effect,it indicates the cause of cataract of the medicines.2.D-thyroxine、Amphotericin B、Vitamin E increase the expression of αsubunit of sodium pump on mRNA level ,from the demonstration of the cell morphology and ultramicroscopic structure ,it indicates the medicines have protective or anti-distructive effect on lens.3.The medicines have isoform-specific action on lens sodium-pump,it indicates exploitting isoform-specific medicine has a promising clinical application.4. Lens sodium-pumps are inhibited probably lead to cataract, so in clinical medication, especially to the cardiovascular doctor, while he is using the sodium-pump inhibitors, he should pay more attention to adjust the dosage and duration of the drug therapy. 5. To creat the animal model of cataract through inhibiting lens sodium-pump, whether it can be a kind of classical method or not, it is worthy of further research.

本研究所选用的药物对晶状体钠泵均有明显的影响作用，在分子水平、细胞水平、组织器官水平均有特异的表现：1、哇巴因、地高辛、二甲基亚砜三种药物可降低晶状体钠泵α亚单位在 mRNA水平的表达，在细胞形态和超微结构上表现为损伤效应，提示了其潜在的导致白内障的可能。2、D甲状腺素、两性霉素B、维生素 E三种药物可升高晶状体钠泵α亚单位在 mRNA水平的表达，从细胞形态和超微结构上的表现，提示了其对晶状体有保护作用或抗损伤效应。3、药物作用于晶状体钠泵具有重整异构特异性，提示了开发出特异的具有重整异构作用的药物是极有临床应用前景的。4晶状体钠泵抑制后可能导致白内障的发生，故临床用药，尤其是心内科医生在使用这些钠泵抑制剂时应注意调整用药剂量及药物疗程。5 通过抑制晶状体钠泵来制作白内障动物模型能否成为一种经典的制作方法，还有待于进一步研究。

RESULT: 1.Ouabain act on lens sodium-pump,under the LM,lens anterior capsular membrane discontinuous,epithelium cells clustered,occluding zonule seperated,lens fiber layers fractured.Under the EM,cells totally hollowed,mitochondria swelling,myelin figure appeared.RT-PCR examine the expression condition of αsubunit of sodium pump on mRNA level,α1、α2 and α3-isoform are all decreased.2.Digoxin act on lens sodium-pump,under the LM,lens cell oedema,linkage distructed,extensive exfoliation.Under the EM,plasma appeared little half-transparant hollow region,mitochondria swelling and ridge disappeared. RT-PCR examine,α1、α2 and α3-isoform are all decreased.3.Amphotericin B act on lens sodium-pump,under the LM,lens epithelium cells linked tightly,arranged in-line,lens fiber layers arranged tightly and regularily.Under the EM,abbundant cellular organes,exuberant cells function indicated. RT-PCR examine the expression condition of αsubunit of sodium pump on mRNA level,α1 and α3-isoform are increased significantly,demonstrated isoform-specific action.4D-thyroxine act on lens sodium-pump,under the LM,lens plasmalemma integrated,cells arranged tightly and regularily.Under the EM,nucleus fission appeared,desmosome half-desmosome and tensile microfilaments linked the cells. RT-PCR examine,α2 and α3-isoform are increased, also demonstrated isoform-specific action.5.Vitamin E act on lens sodium-pump,under the LM,lens anterior capsular membrane continuous and smooth,epithelium cells tightly linked,lens fiber layers appearede hollow region occasionally.Under the EM,lateral membrane high density belt appeared,abundant nucleolus. RT-PCR examine,onlyα1-isoform are increased, demonstrated significantly isoform-specific action.6.DMSO act on lens sodium-pump,under the LM,lens anterior capsular membrane slightly thicker,cells linkage partly distructed.Under the EM,plasmalemma denaturation,mitochondria swelling.RT-PCR examine,α1、α2 and α3-isoform are all altered slightly and haven't significant meanning.

结果：1、哇巴因作用于晶状体钠泵后，光镜下晶状体前囊膜断裂、上皮细胞聚积、闭合连接分离、纤维板层裂隙，电镜下全层细胞空泡化、线粒体肿胀出现髓样结构，RT-PCR法检测晶状体钠泵α亚单位α1、α2及α3三种重整异构体在mRNA水平的表达均减弱。2、地高辛作用于晶状体钠泵后，光镜下晶状体细胞水肿、细胞连接破坏、广泛剥离，电镜下胞质见少许半透明空化区、线粒体肿胀嵴消失，RT-PCR法检测晶状体钠泵α亚单位α1、α2及α3三种重整异构体在mRNA水平的表达均减弱。3、两性霉素B作用于晶状体钠泵后，光镜下晶状体上皮细胞紧密连接、线状排列、纤维板层紧密规整，电镜下细胞器丰富、细胞功能旺盛，RT-PCR法检测α1及α3表达显著增强、具有一定的重整异构作用特异性。4、D甲状腺素作用于晶状体钠泵后，光镜下晶状体质膜完整、细胞排列紧密规整，电镜下胞核见分裂像、细胞间有桥粒、半桥粒及张力微丝，RT-PCR法检测α2及α3表达均增强、亦有一定的重整异构作用特异性。5、维生素E作用于晶状体钠泵后，光镜下晶状体前囊膜连续光滑、上皮细胞紧密连接、纤维板层偶见空化，电镜下囊侧膜内有高电子密度带、细胞核仁丰富，RT-PCR法检测仅有α1的表达显著增强、具有极强的重整异构作用特异性。6、二甲基亚砜作用于晶状体钠泵后，光镜下晶状体前囊膜轻度增厚、细胞连接部分破坏，电镜下质膜变性、线粒体肿胀，RT-PCR法检测晶状体钠泵α亚单位α1、α2及α3三种重整异构体在mRNA水平的表达无显著改变。

Do you know, i need you to come back

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Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。