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Objective To study the relationship among the levels of SOD、MDA and RCD in patients with presbycusis.

目的 探讨老年性耳聋SOD、MDA及红细胞变形性之间的关系,为临床上能有效地控制和延缓老年性耳聋的发生和发展提供依据。

Methods] 36 twomonthold rabbits with white feather and black eyes,half male and half female,were randomly divided into 6 groups:normal group,model group,xiangsha liujun pill group, lizhu changle group, lowdose leweiyintreated group,highdose leweiyintreated group.except the normal group, others were made into ibs model of spleen deficiency which was induced by damp heat stress and gavage with fanxieye as well as method of either hunger or gorge.the drug groups were administered preventively from the mediumterm of the model reproduction to the end of modeling.the rabbits of each group were observed.no,nos,mda,sod in serum and sp in colonic membrane were detected.

方法]两月龄白毛黑眼兔36只,雌雄各半,随机分为6组:正常组、模型组、香砂6君丸组、丽珠肠乐组、乐胃饮低剂量组、乐胃饮高剂量组。除正常组外,其余whbe兔采用湿热环境应激联合番泻叶灌胃加饥饱失常复合方法致脾虚泄泻型ibs模型。从模型复制的中期开始各用药组预防给药,至造模结束。观察各组1般情况,测定血清no、nos、mda、sod含量及结肠黏膜组织中sp含量。

The research confirmed the six indexes could be as resistance criteria of the fivekinds of ever green lianas, they are protoplasmic membrane relativepenetrability, SOD activeness and POD activeness, soluble protein content andsoluble sugar content, the MDA content.

研究证实了质膜相对透性小,SOD活性和POD活性大,可溶性蛋白含量和可溶性糖含量高,MDA含量较低可以作为这五种常绿藤本植物抗逆的六个重要生理指标。

Results(1) In the pyloric ligature model of pyretic syndrome,SOD,EGF andTGF decrease,MDA,NO,iNOS,IL-8 and INF-αexpression,Gas and NE stepup.

结果(1)幽门结扎型胃溃疡热证:SOD活力降低,MDA、NO、iNOS含量升高,IL-8、INF-α表达量增加,Gas含量升高,EGF、TGF-a含量降低,NE、5-HT含量升高。

Detected the content of 5-HT and NE in the brain tissue.Results(1) In the pyloric ligature model of pyretic syndrome,SOD,EGF andTGF decrease,MDA,NO,iNOS,IL-8 and INF-αexpression,Gas and NE stepup.

结果(1)幽门结扎型胃溃疡热证:SOD活力降低,MDA、NO、iNOS含量升高,IL-8、INF-α表达量增加,Gas含量升高,EGF、TGF-a含量降低,NE、5-HT含量升高。

Methods The plasma NO was measured in 40 elderly patients with CHF by colorimetric analysis and SOD activity by the autoxibation of pyrogallic acid.

方法采用比色分析法和邻苯三酚自氧化法测定了40例老年CHF患者的血浆NO浓度及SOD活性。

Animals in those two groups were sacrificed at 24-hour, 72-hour and 7-day after model establishment, six were killed in each group at each time. The tissue of brain was taken out as soon as possible, and the activity of SOD was assayed with auto-oxide of pyrogallic acid.

两组动物分别于造模后24 h,72 h,7 d处死,每次每组处死6只,迅速断头取脑组织,采用邻苯三酚自氧化物测量SOD的活性。

Compared to the control, the increment in membrane permeability, MDA and Pro contents were smaller, and the reducement in activities of SOD and POD, contents in soluble protein, dry weight of aboveground, dry weight of underground, plant height and stem diameter were smaller in leaves of pepper under low temperature and poor light stress with PEG seed-soaking. These results suggested that PEG seed-soaking could increase the resistance ability to low temperature and poor light stress of pepper seedlings.

PEG浸种处理可使辣椒幼苗地上部干质量、地下部干质量、株高、茎粗和叶片SOD、POD活性、可溶性蛋白含量的下降幅度均较低温弱光对照显著减缓,细胞膜透性、MDA与Pro含量的增加幅度均较低温弱光对照显著降低,表明PEG浸种处理能够提高辣椒幼苗对低温弱光的适应能力。

RESULTS:Naokangtai capsule improved the abilites of active and passive learning and memory remarkedly in the model mice with cerebral ischemia-reperfusion injury,but there was no influence to the contents of MDA,SOD and MAO.In senile dementia mice induced by D-galactose,Naokangtai capsule possessed obvious effects of improving memory and spatial resolution and decreased contents of MDA and MAO in blood significantly.

结果:脑康泰胶囊显著增强脑缺血再灌注损伤模型小鼠被动和主动学习能力,但对血液MDA、MAO和SOD含量影响不显著;脑康泰除明显增强老年痴呆小鼠主动学习和空间分辨的能力外,还能显著降低小鼠血液中MDA和MAO水平。

GSTT has protective effects on acute myocardial ischemia induced by ligating left coronary artery in rats in vivo, which is closely related to enhancing removement of free radicals by increasing SOD content, decreasing the leakage of LDH, and inhibiting the apoptosis of cardiomyocytes.

GSTT对结扎大鼠左冠状动脉前降支引起的急性心肌缺血损伤具有保护作用,保护作用通过升高SOD,清除自由基的能力增强及LDH的释出减少进而抑制心肌细胞凋亡。

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