查询词典 sod-bound

Active oxygen is found to be involved in apoptotic progress affected by exogenous SOD and measurement of SOD in cell sap. Arsenic compounds cause a decrease of SOD in cell. It is exactly the decrease that make plenty of active oxygen gather in mitochondria, and starts the apoptotic progress. The analysis of SOD values shows that active oxygen has an effect on apoptosis.

通过加入外源性SOD和对胞液SOD的测量，发现胂化物引起细胞凋亡的过程，有活性氧的参与，并且胂化物还导致细胞内SOD值的减少，正是由于这种降低，才导致了细胞内特别是线粒体中活性氧大量聚集，启动了细胞凋亡过程，通过对SOD值的分析，证明了活性氧在细胞凋亡中的作用。

SOD group was significantly better than U74389G group in coefficient of lung, SOD activity and apoptosis index,（P .01,P .05）. U74389G group was significantly better than SOD group in contents of MDA,(P .01), and there was no significant difference between U74389G group and SOD group in RAC.

SOD组在缓解肺系数、降低SOD活性及抑制凋亡方面优于U74389G组（P 。01，P 。05）；U74389G组在抑制MDA含量方面优于SOD组（P 。01），而两组间RAC差异无显著性。

SOD is existed in any aerobiccell. According to the metalion contained, SOD is devided into four types: Cu/Zn-SOD, Mn-SOD,Fe-SOD and Ni-SOD. Among the total, SOD is studyed more. SOD can catalyze·O_2~- to take place dismutation reaction.

人们发现所有需氧细胞中都存在SOD，按照所含金属离子的不同，SOD可分为四种类型，即：Cu／Zn-SOD、Mn-SOD、Fe-SOD和Ni-SOD，其中Cu／Zn-SOD研究的最多。

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销售类别：小信号开关二极管、肖特二极管、整流二极管快恢复二极管、变容二极管、穏压二极管、瞬变抑制二极管、PIN结二极管、高频检波二极管、多层组整流桥等产品封装：SOD-123 SOD-323 SOD-523 SOD-106 DO-214AA DO-214AB DO-214AC SOT-23 SOT-323 SOT-143 SOT-343 销售系列：1SS系列 1SV系列 1SR系列 BAS系列 HVU系列 BB系列 RB系列 RD系列 SS系列 MMBD系列 SMAJ系列 SMBJ系列 SMCJ系列 MBR系列 HSMS系列 HSMP系列。。。。。。

In this experiment, we screen the major protective antigen gene-SOD gene of M. paratuberculosisin order to study the sensitive, specific diagnostic reagent and prophylaxis preparation, especially theDNA vaccine. The SOD gene was amplified from Mycobacterium paratuberculosis C-2 chromosomalDNA by using the PCR technique and cloned into pMD18-T Vector System. We gained a SOD gene of624bp.The recombinant clone was identified byα-complementarity, enzyme digestion and PCRidentification. The result indicated that the recombinant plasmid pMD18-T-SOD was successfullyconstructed. Moreover, through sequential determination and DNASTAR analysis between the clonedSOD gene of M. paratuberculosis C-2 and that of the M.paratuberculosis K-10 strain, the sequentialhomogeneity reached 99%, and the amino acid homogeneity reached 99.5%. The preceding analysisindicated that the SOD gene was very conservative in M. paratuberculosis.

为了研制副结核病敏感、特异的诊断试剂和新型、高效的预防制剂，尤其是DNA疫苗，本研究筛选了M.paratuberculosis主要保护性抗原SOD基因，以M.paratuberculosis C-2染色体DNA为模板，以SOD基因的特异性引物进行PCR扩增，获得了624bp的SOD基因，通过T-A克隆技术，将PCR产物克隆至pMD18-T Vector中，以质粒大小、酶切分析、PCR扩增及序列分析鉴定重组克隆，成功地构建出克隆质粒pMD18-T-SOD，序列测定及DNASTAR分析表明，所获得的M.paratuberculosis C-2 SOD基因与Gen Bank中M.paratuberculosis K-10 SOD基因的大小完全一致，两者核苷酸序列的同源性为99％，氨基酸序列的同源性为99.5％，表明该基因在副结核分枝杆菌中是高度保守的。

RESULTS The SOD activity had linear correlation with pH in the range of pH 2.2-8.0 when SOD concentration was fixed. The varication of activity after ultrosonication had linear correlcation with fluoresent intensity at 340 nm. With increase of uhtrosonic frequency, the microenviroment of tyrosine and tryptophan inside the SOD molecule was changed, then the balance of hydrophokicity and hydrophilicity inside the molecule was broken, this induced the blue shift of synchronous spectrum band and decrease of SOD activity.

结果 SOD浓度一定、pH2.2~8.0时，活性与其线性相关，超声后活性差值与340 nm荧光强度差值的线性相关；随着超声次数的增加，蛋白质SOD分子内部的酪氨酸、色氨酸所处的微环境被扰动，打破了分子内部的疏水和亲水平衡，使蛋白质的活性降低，在荧光检测中观察到普通荧光谱带蓝移，同步荧光的荧光峰位总体呈现峰位蓝移和强度下降。

objective: to achieve the soluble expression of mn-sod gene in e.coli and assay the enzyme activity of the expressed product. methods: the coding region of superoxide dismutase was amplified using pcr method from the e.coli genome. the pcr product was cloned into puc19-t vector and sequenced.in addition,the cloned coding region of mn-sod was inserted into the expression vector pet-28a to form the recombinant plasmid pet-28a-mn-sod and was then transformed into e.coli bl21 for expression.

超氧化物歧化酶(superoxide dismutase，sod)是细胞体内歧化超氧阴离子自由基(o-2)的一个抗氧化酶，按其结合的金属性离子根据其中金属辅基的不同可分为4类：cu/zn-sod、mn-sod、fe-sod和ni-sod，它们通过催化超氧阴离子自由基0-2发生歧化反应，达到清除o-2的效果，具有防御氧毒性、增强机体抗辐射损伤能力、防衰老以及治疗某些肿瘤、炎症、自身免疫疾病等功效，广受国内外科研工作者的关注和重视[1]。

objective to study gastrodia elata blume to effect tau protein,sod,mda expression in gyrus hippocampi and cerebral cortex of experimental mice.methods to inject okadaic acid to mice ventriculus lateralis and to measure tau protein level,sod activity and lipid superoxide mda content of sod control group,oa injection group,oa and gastiodia elata injection solution group.results tau protein of experimental group(p＜0.05/p＞0.05),sod was lower than model group(p＜0.001) and was higher than control group(p＜0.05).conclusion gastrodia elata blume can increase sod activity and reduce tau protein expression and superoxide lipid forming in brain tissue of experimental dementia mice caused by oa.it can prevent and treat ad.

目的 观察天麻对痴呆模型大鼠海马、皮质神经元微管相关蛋白、超氧化物歧化酶和脂质过氧化物丙二醛表达的影响，探讨其治疗阿尔茨海默病(alzheimer disease，ad)的作用机制。方法用冈田酸(okadaic acid，oa)注射大鼠侧脑室造模，测定模型组、实验组、对照组海马和皮质tau蛋白、sod、mda的含量。结果实验组tau蛋白低于模型组(p＜0.001)，高于对照组(p＜0.05)；sod高于模型组(p＜0.001)和对照组(p＜0.05)；mda低于模型组(p＜0.001)，高于对照组(p＜0.05)。结论天麻可增强oa致实验性痴呆大鼠脑组织sod活性，降低mda蓄积和tau蛋白生成，具有防治阿尔茨海默病的作用。

Objective: To colone SOD gene, construct combinant of retrovirus SOD gene, make a basis of gene transfection and over-expression of gene therapy.

目的 通过克隆SOD基因，构建逆转录病毒-SOD真核表达载体转染复合体，为基因转染及SOD的过表达提供基础，为将来的基因治疗进行准备，也为深入研究SOD功能及SOD的开发创造条件。

The results showed that there were prominently positive correlations between rates radioactivity of SOD and POD and a good minus correlation between rates radioactivity of SOD and PPO. With irradiated by 60Co-γ ray of 10GY, rates radioactivity of SOD and POD were highest, and rate radioactivity of PPO was secondary, and rate radioactivity of CAT and the content of malondialdehyde were eighthly.

结果表明，SOD酶活力与POD酶活力之间呈显著正相关R=0.656(上标*，SOD比活力与PPO酶活力、PPO比活力之间呈极显著负相关R=-0.716(上标*， R=-0.714；SOD酶活力、POD酶活力以10GY辐射处理值最高，10GY辐射处理的PPO酶活力居第2，丙二醛含量及CAT酶活力居第8。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。