查询词典 smoothened

Specific inhibition of Hh signalling using small molecule inhibitors, a neutralizing anti-Hh antibody or genetic deletion of smoothened in the mouse stroma results in growth inhibition in xenograft tumour models.

由癌细胞分泌的Hedgehog配体，在肿瘤表皮细胞中未能激活信号作用，而是在&基质&上发挥作用（&基质&由细胞外基质、成纤维细胞、内皮细胞和微血管组成，恶性细胞着床于其中）。

By means of equalizing the histogram, the contrast of original thermal image is enhanced; then image region of the disc surface of insulator is intercepted manually; through the envelope of the smoothened histogram of thermal image the segmentation threshold is extracted and the morphological filtering is applied to the threshold- segmented binarized image to obtain insulator disc surface image and background image, and then 10 infrared image features of insulator disc surface image and background image, such as the highest temperature, the lowest temperature, mean temperature, variance of temperature distribution of both kinds of images, as well as maximum temperature rise and mean temperature rise of insulator disc surface relative to background, are extracted; finally, the good and bad features are discriminated by single factor variance analysis, thus the feature selection is implemented.

利用直方图均衡化增强原始热像图对比度，人工截取绝缘子盘面图像区域；通过平滑后的图像直方图包络线提取分割阈值，对阈值分割后的二值图像进行形态学滤波，得到绝缘子盘面图像和背景图像，提取2者的最高温度、最低温度、平均温度、温度分布方差以及盘面相对于背景的最大温升和平均温升共10个红外热像特征；应用单因素方差分析甄别特征优劣，实现特征选择。

In vertebrate organisms,thesignaling pathway is initiated by the binding of ligandsto the membranousreceptor patchedwhich in turn alleviates the suppression on smoothened,subsequently Smo triggers a series of intracellular events with resultant activation of thezinc-finger transcription effectors,glioma-associated oncogenes(Glil,Gli2,Gli3)transcription factor,which induces the expression of numerous target genes,such as Ptch-1,Hip,Gli1 and Wnt,that regulate proliferation,differentiation.

Hedgehog信号通路是高度保守的调控胚胎组织分化发育的通路，在脊柱动物体内，Hh蛋白与跨膜受体Ptch结合后，解除了Ptch对Smo的抑制，随后Smo从共受体上解离下来进入胞浆，将信号下传并激活锌指转录因子Gli，后者启动Ptch-1、Hip、Gli1、Wnt等目的基因的表达，进而调控细胞的增殖、分化。

However, as the name（read－only memory）implies, CD disks cannot be written onorchanged in any way.

然而，正如其名字所指出的那样，CD盘不能写，也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口，替代木托盘，免薰蒸，符合欧盟、北美各国对出口货物包装材料的法令要求；喷涂钢托盘适用于重载上货架之用，托盘表面根据需要制作成平板状、波纹状及间隔形式，满足不同的使用要求。