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We studied thickness and area of airway smooth muscle and airway wall, standardized by perimeter of basement, and examined Brdu positive cell nucleus of airway smooth muscle, expression of phenotype mark protein such as sm α-actin, sm-MHC and calponin of airway smooth muscle by immunohistochemistry.

设立正常组、模型组、中药组、西药组和中西结合组,采用免疫组化方法分析激发二周、四周哮喘大鼠中、小气道壁厚度及面积、气道平滑肌厚度及面积、气道平滑肌细胞Brdu掺入、气道平滑肌表型标志蛋白(sm α-actin、sm-MHC、calponin)表达情况。

RESULTS: A total of 36 rabbit models, 6 in the 1-month therapy group and 8 in the 3-month therapy group were died from infection. In the 1-month therapy group, thick ureteric wall and smooth ureteric lumina developed without any contracture. Under the optical microscope, transitional epithelial cells covered throughout the inner walls and smooth muscle cells appeared sparsely in a mussy configuration. In addition, CKAE1/AE3 staining was positive butα-actin staining was very weak when checked by immunohistochemistry. In the 3-month therapy group, amnion-ureters were enclosed by their peripheral tissue and showed rich blood vessels and normal ureteric lumina without significant contracture, futher more, there had formed a well-arranged transitional epithelial layer and smooth muscular layer, the immunohistochemistry result showed that the expression of CKAE1/AE3 and α-actin were positive.

结果:36只大白兔中,1个月治疗组死亡6只,3个月治疗组死亡8只,死亡原因均为感染。1个月治疗组大白兔羊膜输尿管柔软,长4 cm,管壁变厚,无挛缩,移行上皮组织爬满内壁,平滑肌组织部分再生,但较稀疏,排列不规则;免疫组织化学检查提示CKAE1/AE3染色阳性,α-Actin染色微弱。3个月治疗组大白兔羊膜输尿管与周围粘连,有丰富的血运,无明显挛缩,管腔不缩小,已形成良好的移行上皮层和平滑肌层,免疫组织化学显示α-Actin和CKAE1/AE3染色均为阳性。

Wenxin capsule can promote endolethial cells releasing CO and synthesing 〓, enhance activity of HO, induce angiectasis through activating guanylic cyclase and adenglate cyclate of intracellar of vessel smooth muscle cell to enhance content of intracellar cGMP and AMP. 3. Wenxin capsule can inhibit releasing of platelet activiting factor 〓 which inhibit platelet aggregation and have antithrombosis function. 4. Wenxin capsule can promote activity of t-PA, reduce activity of PAI-1, strengthen fibrinolytic function, therefore inhibit fibrin disposition. 5. Wenxin capsule can inhibit synthesis of smooth muscle cellular DNA. Its function don't kill it directly but prevent transformation from period Go to peried S. 6. Wenxin capsule is an effective prescription of anti-coronary atherosclerosis atherosis. The results of image pattern analysis tastifies that area of lipid plaque in treating group reduce 54% and 58% in contrast with that in control group. The results of light, electro- microscopy show that structure of endolethial cell and smooth muscle cell in treating group is more integral than that in control group.

其作用机制之一是由于该药具有良好的调脂降脂作用,其不仅能明显降低血清LDL-c及升高HDL-c含量,且能有效阻止TC沉积于血管壁,从而保护内皮细胞结构完整;此外,温心胶囊尚具有明显的抗氧化作用,该药不仅能明显降低血浆LPO含量,且能提高SOD活性,同时其对血红素在细胞内代谢的调节作用也参与了抗氧化过程。2 温心胶囊能明显促进内皮细胞释放CO及合成〓,提高HO活性,通过激活血管平滑肌细胞内鸟苷酸环化酶及腺苷酸环化酶引起细胞内cGMP、AMP浓度增加而引起血管舒张。3 温心胶囊能明显抑制血小板激活因子〓的释放,从而抑制血小板聚集,抗血栓形成。4 温心胶囊能明显提高t-PA活性,降低PAI-1活性,增强纤溶功能,从而抑制纤维蛋白沉积。5 温心胶囊能明显抑制平滑肌细胞DNA合成,其抑制作用不是直接杀伤抑制,而是阻止细胞由Go期向S期转化。6 温心胶囊是抗冠状动脉粥样硬化的有效制剂,图象分析结果证实,该药治疗组脂斑面积比对照组缩小了54%和58%,光电镜结果显示内皮细胞及平滑肌细胞结构较为完整。

Results showed:(1) The airway responsiveness of smoke control group was higher than that of normal control group, the airway responsiveness of smoke + exercise group was lower than that of smoke control group;(2) Plasma level of cortisol determined immediately after exercise was higher than that determined before exercise, no significant difference occurs between that determined next day morning after all exercise finished in contrast to that determined before exercise;(3) HE staining showed, there was severe chronic pulmonary inflammatory response in smoke control group, which was reduced in the smoke + exercise group;(4) chronic cigarette smoke downregulated the protein and mRNA expression of BKca in smooth muscles of bronchi and bronchioli, exercise increased the mRNA expression of BKca;(5) chronic cigarette smoke downregulated the protein and mRNA expression of Kv1. 5 in smooth muscles of bronchi and bronchioli, exercise increased both the protein and mRNA expression of Kv1. 5 in contrast to smoke control group in bronchioli and did not effect the expression of Kv1. 5 in bronchi;(6) chronic cigarette smoke induced upregulation of FIZZ1/RELMα in bronchial smooth muscle cells, exercise decreased these effect.

结果:(1)吸烟对照组的气道反应性明显增高,吸烟加运动应激可明显降低大鼠的气道反应性;(2)吸烟运动组运动后血浆皮质醇浓度明显高于运动前,但全部运动结束后次日晨测定的血浆皮质醇浓度与运动前无明显差异;(3)HE染色显示,吸烟对照组肺组织出现明显的慢性炎症反应,吸烟加运动应激组比吸烟对照组炎症反应轻;(4)慢性吸烟可降低大鼠大气道和小气道BKca mRNA和蛋白表达,而吸烟加运动应激可使BKca mRNA表达上调,但对小气道的蛋白表达无影响;(5)慢性吸烟可降低大鼠大气道和小气道Kv1.5蛋白和mRNA表达,在小气道吸烟加运动应激可减轻这种作用,大气道则无作用;(6)吸烟使支气管平滑肌的FIZZ1/RELMα蛋白表达明显增强,而吸烟加运动组的RELMα蛋白及mRNA均明显减弱。

Study K2-xLa2Ti3-xVxO10 serves as smooth activator to be more than 290 Nm ray radiation to fall in wavelengh, splitting decomposition aquatic product gives birth to hydric smooth catalysis active, discuss V5+ to adulterate the influence of active of smooth catalysis of K2La2Ti3O10 of mine of calcic to layer shape titanium.

探究K2-xLa2Ti3-xVxO10作为光催化剂在波长大于290 nm光辐射下,裂解水产生氢气的光催化活性,并讨论V5+掺杂对层状钙钛矿K2La2Ti3O10光催化活性的影响。

Rainbow closionne craft picture product characteristic: Pinches the silk to be smooth, the color gentle transition nature, the color purity and brightness are high, surface smooth smooth, and the reflection rate low, never distorts, does not fear and so on characteristics moistly.

彩虹景泰蓝工艺画产品特点:掐丝流畅、色彩柔和过渡自然、色彩纯度及亮度高、表面光滑平整且反光率低、永不变形、不怕潮湿等特点。

Both overlong or overshort bottom duration and overlong or overshort fluctuation period are unfavorable for reduction of non-diamond content. Only moderate ones have optimal effects on it.3 Compared with a smooth microwave, a fluctuating one can reduce the diamond nucleation density slightly.4 In fluctuating microwave, even if a higher CH〓 concentration chosen, diamond films with quality better than that of those deposited at a lower CH〓 concentration and in smooth microwave can be obtained.In smooth microwave, the influence of O〓 upon the diamond films'MWPCVD was investigated. It is found that:1 In the range of lower O〓 concentration, its increase is beneficial to improvement of quality of diamond films, but in that of higher one, its increase conversely deteriorates the quality of diamond films.

在脉动微波下进行了沉积金刚石膜的研究,得到下述结果:1)采用合适的脉动微波,能使金刚石膜的沉积质量显著提高,并能使金刚石膜中的微晶石墨得到几乎完全的抑制。2)过长或过短的平底时间或脉动周期均不利于金刚石膜中非金刚石相碳含量的降低,只有适中的平底时间或脉动周期才有最佳的降低非金刚石相碳含量的效果。3)脉动微波会使金刚石的形核密度有所下降。4)脉动微波下,即使选用较高的CH〓浓度,也能得到沉积质量比在平稳微波下采用较低的CH〓浓度所制备的金刚石膜的沉积质量要明显提高的金刚石膜。

Firstly, we investigated the mechanism of material removal and formation of super smooth surface in CMP. And the material removal mechanism of CMP at atomic level was described. The comprehension and hypothesis of material removal mechanism of super smooth surface polishing were enunciated. For instance, we circumstantiated material removal mechanism and formation of super smooth surface in CMP of LBO crystal.

化学机械抛光是超精密加工技术中最重要的方法之一,作者首先调研化学机械抛光的材料去除和超光滑表面形成机理,研究原子级材料去除机理,提出对化学机械抛光材料去除和超光滑表面形成的理解;并以LBO晶体为例详细描述化学机械抛光过程中材料去除和超光滑表面形成。

The results show that the concave structure ameliorates the surface stress distribution of the non-smooth sample, makes the local stress between concaves less apparently than that of the smooth sample, that means the local low stress areas are formed on the non-smooth surface.

结果表明:在受力状态下,仿生非光滑凹坑改善了试样表面的应力分布,使非光滑试样表面凹坑间的区域局部应力明显小于光滑试样表面的应力,即产生了局部低应力区。

The dynamic surface controller design method of the nonlinear autopilot for high maneuver missile is developed. Based on the smooth second-order dynamic sliding mode, the designed virtual controls are smooth enough and needn't smooth by integral filters when designing the inner loop controller with back-stepping method. So it overcomes the problem of explosion of terms.

提出了高机动非线性导弹自动驾驶仪的动态面控制器设计方法,该方法基于光滑二阶动态滑模,所设计的虚拟控制足够光滑,在利用反步法设计内环控制器时不需要进行积分滤波克服了反步法所带来的项数膨胀问题。

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