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Similarly, if the morphic form of the API is changed through unassessed changes in the API manufacture, this could have a considerable effect on the bioavailability of the drug product.

类似地，如果在原料药生产过程中，原料药的形态发生了巨大的变化，这可能对制剂的生物利用度产生相当大的影响。

Majority of acute leukemias in infant, either acute lymphoblastic leukemia or acute myeloblastic leukemia, posses a chromosomal translocation affecting the 11q23 chromosome region which specifically inoles the mixed-lineage leukemia gene.1-3 Most pediatric leukemias with MLL rearrangement clearly hae a remarkably short latency.1,4 MLL gene rearrangement is also associated with secondary leukemias of patients preiously treated with the topoisomerase II inhibitors.4 The latency of these secondary leukemias is similarly ery short.4 Of note, the concordance rate of leukemia with MLL rearrangement in infant monozygotic twins approximates to 100%,1,4 and identical breakpoint in the MLL gene was shared in these pairs of identical twin infants with concordant ALL.1,4 Moreoer, the unique and clonotypic MLL fusion gene was detectable in neonatal blood spots for Guthrie cards from non-twined indiiduals who subsequently deeloped ALL.1,4 These obserations indicate not only that MLL fusion is generated in utero but also that MLL fusion proteins could be capable of inducing leukemic transformation with few, if any, secondary mutations.2,3,4 Greaes et al speculate that an MLL fusion protein somehow promotes rapid transition to full-blown disease in patients ia ery rapid clonal expansion, genetic instability, or inhibition of DNA damage repair.4 In general, for clonal expansion of malignancies, tumor cells often hae acquired strategies that escape immune sureillance of the hosts.5,6 Immune escape mechanisms also contribute to the failure of graft-ersus-leukemia effect after allogeneic hematopoietic stem cell transplantation.7 Therefore, leukemia cells could acquire some immune escape mechanisms during leukemogenesis.

绪论 绝大多数的婴儿白血病，不管是急性淋巴性白血病或是急性骨髓性白血病，在染色体11q23部位有染色体易位的情况；这个部位的染色体易位牵连了混合谱系白血病基因。大多数具有MLL基因重排的儿童白血病潜伏期明显短很多。MLL基因重排也和经拓扑异构酶II抑制剂治疗后的继发性白血病有关。这些继发性白血病的潜伏期类似地都非常的短。很重要的是，单卵双胞胎婴儿同时患有或同时免于MLL基因重排阳性的白血病的一致性接近100%；并且同样患有ALL的同卵双胞胎的MLL基因的断裂点是一致的。而且，这种独特的克隆特异性的MLL融合基因能够从那些得ALL的非双生个体出生时的血斑标本中检测到。这些发现表明MLL融合基因产生在胎儿还在子宫的是后，而且MLL融合蛋白能过和其他的基因突变一起诱导白血病的产生。Greaes 等推测MLL融合蛋白在某种情况下同过快速克隆增殖，遗传的不稳定性或是DNA损伤修复的抑制促使疾病迅速地全面爆发。恶性肿瘤细胞的克隆增殖通常已经获得了逃避机体免疫监视的能力。免疫逃避机制也归因于异体外周血干细胞移植后移植物抗白血病作用的失效。所以，白血病细胞在白血病的产生过程中可能获得了某些免疫逃脱机制。

Similarly, Bosken and colleagues25 found no difference in the intensity of the airway neutrophilia between smokers with and without airway obstruction.

类似的，Bosken与同事们并没有在有或无气道阻力的吸烟人群发现气道中性粒细胞数目的区别。

Similarly, in the Nicomachean Ethics, Aristotle does not lay down any hard and fast rules regarding virtue because different behaviors are virtuous in different situations.

同样，在尼各马科伦理学，亚里士多德没有放下任何硬性规定，因为不同的关于美德的良性行为在不同情况下。

In fact, the other thing that I can remember about you now, the other thing that happened two years ago at Beijing's Banana, similarly started with thunderous excitement, which suddenly turned into utter noiselessness.

事实上，我现在记得关於你的另一件事，发生在前年北京Banana内的另一件事，同样地从缤纷喧闹，忽然变得静默无声。

Similarly, patients with persistently uncontrolled BP were more likely to be nonadherent to medications (OR=1.50) and to have had therapy intensified （OR=2.86 than those with normal BP that remained controlled.

简单地说，持续高血压患者多数药物依从性差(OR=1.50)，并且比血压控制正常的患者更多地采取强化治疗的手段。

In nonclinical tests, the sample may be a small volume of solution prepared from soil, dust, plants, or food, and similarly applied directly to the membrane test strip.

在非临床检测中，样品可能有由土壤、灰尘、植物或食物等准备好的小量的溶液，类似的直接应用在膜试纸条上。

The results are used to the values obtained are in good agreement with the experimental results, similarly calculation of noncritical phase matching temperature for SHG gives a result which also agrees with the experimental result fairly well.

用此结果计算室温的二次谐波I类临界相位匹配角与实验值符合得很好，又计算二次谐波的非临界相位匹配温度，其结果也与实验值较符合。标签镁铌酸锂晶体折射率测量 MgO LiNbO3 crystal refractive measurements

Similarly, a nonreference return value ( Section 7.3.2, p. 247) is returned by copying the value in the return statement.

类似地，以非引用类型作返回值时，将返回 return 语句中的值的副本（第 7.3.2 节）。

Similarly, the nonstatic member functions in the enclosing class have a this pointer that points to an object of the enclosing type. That object has only the members defined in the enclosing class.

同样，外围类中的非静态成员函数也具有 this 指针，它指向外围类型的对象，该对象只具有外围类中定义的成员。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐