查询词典 signaling

"This can be done by using a noel drug to block the Notch pathway while simultaneously controlling estrogen signaling through the estrogen receptor," said Albain, director, thoracic oncology clinical research program; director, breast clinical research program; and co-director, multidisciplinary breast oncology center; Loyola Uniersity Health System, Maywood, Ill.

&这种现象可以通过使用一种新的药物阻断Notch途径同时通过雌激素受体控制雌激素的信号转导来解决，&Albain说，他还是伊利诺州Maywood，Loyola大学健康系统的多学科乳腺肿瘤中心的主任，乳腺临床研究计划的主任，胸部肿瘤临床计划的主任。

For automatic sprinklers fire protection service and signaling systems for branch lines.

用于自动喷淋消防系统和直线管道上的信号系统。

Norway's central bank cut rates by half a percentage point to 4.75 percent, signaling more moderate cuts ahead to help shield the oil-fueled economy from the crisis.

罗威中央银行降息半个百分点到了4.75个百分点，发出适度信号提前消减帮助保护危机中的然有经济。

In mammals, the Notch signaling pathway is critical for embryonic development, as targeted disruption of Notch1 or its downstream transcription factor RBP-J in mice resulted in disorganization of somites and delayed closure of neurotube, which finally leads to early embryonic lethality.

Notch信号途径在哺乳动物的胚胎发育中起着关键的作用。

Twelve members of JASMONATE ZIM-DOMAINproteins, repressors of the transcription of jasmonate-responsive genes, have recently been isolated and characterized in the model plant Arabidopsis thaliana, which is a great progress in the molecular mechanism for jasmonate signaling in plant kingdom.

最近，从模式植物拟南芥中分离鉴定了茉莉酸响应基因的转录抑制因子JAZ（茉莉酸ZIM结构域蛋白）蛋白家族的12个成员，这是植物茉莉酸信号途径分子机制研究的重大进展。

GA promotes plant growth via 26S proteasome-dependent proteolysis of DELLA proteins repressors, one of the key component in GA signaling, and also depends on GA-mediated interaction between GA receptor and DELLA proteins. Finally, this paper discussed the cross-talking between GA and other hormones, and modulation of adaptation to environments.

本文综述了赤霉素生物合成的生物学途径及其调控研究； GA信号转导通道的研究进展，特别是DELLA蛋白阻遏植物生长发育的分子机理和GA解除阻遏作用的分子模型； GA受体研究的新进展；探讨GA与其它激素之间的相互作用，以及植物在应答环境过程中的作用。

And ZNF397nf function as transcription repressors. The different transcriptional regulation activity of the nf isoforms and their interaction with the fu isoforms would contribute to the complexity of the transcription regulation. To further examine the biological function of interaction between different isoforms we also analyze the potential role of ZNF191 and ZNF434 on signaling pathway. We found that ZNF191fu can significantly enhance the HSE-luciferase activity, while ZNF434fu can enhance the AP1-luciferase activity, then we analyze whether the nf isoforms have impact on the fu isoforms.

而这些成员的nf剪接本与它们对应的fu剪接本的转录调控功能有所不同，其中ZNF191nf与ZNF434nf剪接本的转录调控活性相对它们的fu剪接本显著降低，呈现较弱的转录抑制作用，但ZNF447nf剪接本却呈现出显著的转录激活作用，同时ZNF397nf剪接本则表现出显著的转录抑制作用，ZNF396nf剪接本的转录调控作用与其fu剪接本相当。nf剪接本这种与fu剪接本不尽相同的转录调控活性以及能与fu剪接本互作的能力，大大增加了转录调控作用的复杂性，这使得通过少量的转录因子作用来实现众多基因时空表达的不同成为可能。

After selecting a highly potent strain of poxvirus that was able to traffic to tumors when administered intravenously to mice the authors engineered the virus such that it would target only specific cancer cells -- those with increased expression of a protein known as E2F and/or activation of signaling downstream of a protein known as EGFR.

在选择高度特异性痘状病毒后才能有效的到达肿瘤生长地方，然后通过静脉途径给老鼠。这些病毒都是研究人员设计好的以至于只能到达特异性肿瘤细胞，像那些增加表达蛋白E2F和信号下游活化蛋白EGFR。

After selecting a highly potent strain of poxvirus that was able to traffic to tumors when administered intravenously to mice the authors engineered the virus such that it would target only specific cancer cells -- those with increased expression of a protein known as E2F and/or activation of signaling downstream of a protein known as EGFR.

以毒攻毒：设计病毒，攻击肿瘤一种新的治疗癌症的方法正在开发中：用病毒感染肿瘤杀死癌细胞留下正常细胞不被伤害。这些病毒以病毒疗法而著称。在一项新的研究当中，David Kirn 和他在旧金山Jennerex生物疗法同事已经描述出利用新病毒疗法后老鼠和兔子抗肿瘤效应的发展。在选择高度特异性痘状病毒后才能有效的到达肿瘤生长地方，然后通过静脉途径给老鼠。

Features that remain constant throughout recorded language history are identical with language universals encountered in modern languages. Thus, we find changing inventories of phonemes but complete constancy in the basic phonematic mode of signaling. All languages are and have been phoneme-language throughout the documented past. Sound analogy or sound imitation is never encountered un-phonematized.

在历史的纪录中，恒定的特徵在所有语言中是普遍相同的，现代语言也不例外，因此我们发现音素的存留虽有改变，但是在发出信号的基本音位调式上是完全恒定的，由历史纪录可知，所有语言都是以音素为本的语言，声音的类比和声音的模仿永远都是音素化的。

She gently rebuff ed him, but agreed that they could be friends

她婉言拒绝了，但同意作为朋友相处。

If in the penal farm, you were sure to be criticized.

要是在劳改农场，你等着挨绳子吧！