查询词典 signaling

One year later, Slit was confirmed as the ligand of Robo and the Slit-Robo signaling is know involved in the repulsive effect of the commission axons crossing the mid-line, and also involved in the repulsive effect of the guidance of neuronal migration and leukocyte migration as well.

而对 Slit 功能展开的研究起于1998年，先是发现其受体 Robo突变型果蝇的中线处交叉神经元的导向发生缺陷。1999年的一系列遗传和生化的研究又发现，分泌性因子 Slit 正是 Robo 的配体， Slit － Robo 信号起到了排斥一些轴突，使之无法穿过中线的作用。

Baicalin could inhibit the initial-period and mid-period activation of mouse T lymphocytes stimulated by Con A or PDB,which suggests that baicalin have the inhibitory effect on signaling pathway of T lymphocytes activation and be a potential effective immunoinhibitory agent.

结论黄芩苷能够明显抑制多克隆刺激剂Con A或PDB诱导的T细胞早期和中期活化，且呈明显的量效关系。提示黄芩苷在T细胞活化过程的信号转导中有抑制作用，从而可以通过抑制T淋巴细胞的活化，发挥免疫抑制作用，是一种潜在的免疫抑制剂。

To investigate the change of mitogen activated protein kinase signaling pathway during prostate cancer progression, and therefore to explore its role on cell proliferation.

目的：研究前列腺癌进展中细胞丝裂原活化蛋白激酶信号通路的变化，探讨阻断此通路对前列腺癌细胞增殖的影响。

EGFR activation induced activation of several downstream intracellular substrates, leading to mitogenic signaling and other tumor-promoting cellular activities.

在许多不同的人类癌症中，包括口腔癌，EGFR有过度表现的情形。

It has been reported that in the absence of stress, p53 promotes cell motility by modulating intracellular signaling pathways, rather than by stimulating the production of secreted mitogenic factors.

据文章报道，在没有外界压力的情况下，p53可以促进细胞迁移，而缺乏p53的细胞其迁移能力减弱。

Nicorandil inhibits muscarinic activation of the ERK signaling pathway by reducing the intracellular Ca(2+) concentration.

尼可地尔通过减少细胞内钙离子浓度能阻断毒蕈碱细胞外信号调节激酶信号路径的激活。

Monocyte chemotactic protein-3 (MCP-3) interacts with multiple leukocyte receptors: bin-ding and signaling of MCP-3 through shared as well as unique receptors on monocytes and neutrophils. Eur J Immunol, 1995; 25:2612-261711 Warrens AN , Jones MD, Lechler RI, et al.

实验中发现，重叠延伸拼接PCR过程中碱基与模板的错配率要明显高于常规PCR反应，即使使用保真性较好的聚合酶也不能避免错配的发生，而可能导致碱基序列的点突变。

Noggin induces the nerve tube formation. It binds and inactivates members of the transforming growth factor-beta superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). Proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) are related to noggin mutations.

Noggin能使紫外线人工腹侧化的爪蟾胚胎重新恢复背-腹的身体轴；在神经系统中诱导神经管的形成；减弱包括骨形态发生蛋白在内的转化生长因子信号蛋白的活性，从而控制骨的生长；调控生殖系统的发育。

Fluid shear stress synergizes with insulinlike growth factorI on osteoblast proliferation through integrindependent activation of IGFI mitogenic signaling pathway［J］.

模拟失重对成骨细胞功能的影响我们前期研究发现，在FSS的作用下，1 G重力环境下培养的成骨细胞分泌的PGE2可迅速增加。

The engagement of TREM-1 synergizes with the Toll-like receptors signaling pathway in amplifying the inflammatory response mediated by several microbial components.

多种细菌性成分能使细胞表面的TREM-1表达增加，后者与Toll样受体协同作用，激发炎症因子的产生。

She gently rebuff ed him, but agreed that they could be friends

她婉言拒绝了，但同意作为朋友相处。

If in the penal farm, you were sure to be criticized.

要是在劳改农场，你等着挨绳子吧！