查询词典 showed

Results:Main imaging features of APK were as follows:On abdominal plain films showed the lobalate renal enlargement in 46 cases,calcification of polycystic wall in 14 cases,renal calcium milk in 5 cases,60 cases were showed separation,deform and longthend of renal pelvis on intravenous urography and retrograde urography,5 cases were showed renal enlargement on retroperitoneal pneumography,on CT scans in 25 cases showed mulltiply cysts with thin wall,unecho liquid shadows were showed on B-mode ultrasound.

结果：成人多囊肾的主要影像学征象：腹部平片(46例)显示肾影呈分叶状增大；囊壁钙化(14例)；多囊肾合并肾钙乳(5例)；肾盂造影(60例)，表现为肾盂、肾盏相互分离、变形、拉长；腹膜后充气造影(5例)：表现为肾影增大肾影与邻近器官之间的关系，其界限清晰可辨；CT扫描(25例)：表现为肾内多数大小不等的薄壁圆形低密度区；B型超声(47例)表现为肾内多个类圆形无回声的液性暗区。

Dexamethasone treatment group, the hearts showed cardiac musclewaxy necrosis, bubble apomorphosis, the livers showed a large area of cellularnecrosis, the spleens showed hemorrhagic infarct, the lungs showed hemorrhage andhyperemia, serous fluid exudation, the kidneys showed granular degeneration, thecerebrum showed nerve cell swelling.

地塞米松治疗组的心脏表现为心肌发生蜡样坏死，水泡变性；肝脏表现为肝组织出现大面积坏死；脾脏表现出血性梗死；肺脏表现为出血充血，浆液渗出；肾脏表现为颗粒变性；大脑表现为神经细胞肿胀，变圆。

Results Among all 25 cases of lymphangioma,Within 20 cases of cystic lymphangioma,single cyst was showed in 14 cases and multilocular cyst was showed in 6 cases in plain scan,and little enhancement of capsule wall and septal in 8 cases in enhancement scanning. Cystic-solid mass was showed in 4 cases of cavernoma lymphangioma in plain scan,and solid part of mass was enhanced obviously in enhancement scanning.1 capillary ymphangioma showed the skin and hypodermic thicking,and part of area showed little beehive-like feature. Enhancement scanning showed slight irregularity enhancement.

结果 25例淋巴管瘤中20例囊性淋巴管瘤，CT平扫14例表现为单一囊肿，6例表现为多房性囊肿，囊腔内见有分隔；增强扫描8例出现囊壁或间隔的轻微强化。4例海绵状淋巴管瘤平扫均表现为囊实性肿块，增强检查实性部分有明显分期增强；1例毛细管型淋巴管瘤表现为局部皮肤及皮下组织的增厚，部分区域见有小蜂房样表现，增强扫描见有轻度不规则强化。

The study showed the recombinant wt/mCREG protein depressed the VSMC proliferation depending on dose and the optimal concentration was 400nM;2biologic function of CREG protein and the membrance receptor mechanism:①effect on VSMC migration: the wound healing experiment showed the OB2 cells migration was slower significantly after added wt/mCREG(400Nm) in supernatant. The HITASY cells migration were very slowly and no remarkable change. The gelatinase digestion and Western blot analysis showed the matrix metalloproteinase was decreased and TIMPs was increased;②effect on differentiation: after added wt/mCREG(400nM), the expression of myocardin, SMα-actin, MHC and caldesmin were increased and that of LM-1 and FN were decreased in OB2 cells. These effects were more significant when adding wtCREG.;③effect on VSMC proliferation: Cell cycle assay and BrDU stain showed: after added the wtCREG and mCREG protein, the ratio of cell in G0/G1 phase increased to 0.5773 and 0.5572 from 0.5308 respectively in OB2 group, which increased to 0.7369 and 0.7034 respectively from 0.6297 in HITASY group;3Role of M6P/IGF2R in CREG biologic function:①ELISA and co-immunoprecipitation showed the wt/mCREG binding to M6P/IGF2R directly.②antibody blocking test: when the anti-IGF2R was added to medium at the same time with wt/mCREG at different concentration(2μg/mL、4μg/mL、8μg/mL),the effects of CREG protein which depressing proliferation, migration, secretion and promoting differentiation were blocked, which had the positive correlation to the concentration of added anti body. The studies showed two combinant CREG promoted VSMC switch to differentiation phaenotype, at the same time, depress VSMC proliferation, migration and secreting extracellular matrix.

上述实验结果证实：两种重组CREG蛋白对VSMC增殖均有剂量依赖性的抑制作用，并且相同浓度的糖基化的CREG蛋白对细胞增殖的抑制效应更为显著，最佳效应浓度为400nM；2两种重组CREG蛋白添加后对HITASY和OB2细胞生物学行为的影响：①CREG蛋白对VSMC迁移的影响：刮伤实验发现，加入最佳效应浓度的wtCREG和mCREG蛋白24h后，OB2组迁移能力下降，HITASY组无明显变化；细胞外基质金属蛋白酶-2，9(Matrix metallo-proteinase 2，9，MMP2 ，9)明胶酶电泳检测和Western blot检测结果证实，两种CREG蛋白均可以使OB2细胞合成细胞外基质MMP2，9减少，而组织金属蛋白酶抑制物(Tissue Inhibitors of Metalloproteinases，TIMPs)增加；②CREG蛋白对VSMC分化的影响：加入400nM的wtCREG和mCREG蛋白12h后，OB2细胞myocardin、SMα-actin、MHC、caldesmin表达增加，LM-1、FN表达减少；③流式细胞仪分析细胞周期和BrDU染色分析证实，加入400nM的wtCREG和mCREG蛋白后，OB2组G0/G1期细胞由0.5308分别增加至0.5773和0.5572，HITASY组G0/G1期细胞由0.6297分别增加至0.7369和0.7034；3M6P/IGF2R在重组CREG蛋白的生物学功能中的调控作用：①免疫共沉淀和免疫荧光双染色分析结果显示，CREG蛋白与M6P/IGF2R存在直接结合；②应用抗体阻断实验：将不同浓度的anti- M6P/IGF2R(2、4、8μg /mL)与两种CREG蛋白同时加入培养液中，CREG蛋白抑制VSMC增值、迁移和合成细胞外基质、促进分化的效应减弱，而且与加入anti- M6P/IGF2R浓度正相关。

The biomechanical tests showed that two kinds of artificial bones had not significant difference on compressive strength and Young\'s modulus(P＞0.05),while the flexural strength of nano-nacre artificial bone was less than the control group(P＜0.05).3.The results of CCK-8 showed that the difference were not significant in each group,the proliferation of osteoblast reached the peak at the 5th day;7 days after being co-cultured,the total protein content of study group was higher than control group and blank group(P＜0.05),while the difference between control group and blank group was not significantP＞0.05The difference of alkaline phosphatase activities among three groups was not significant(P＞0.05The SEM view showed that osteoblast attached and grew well in two kinds of artificial bone.4.X-ray photography showed that two kinds of powder started to degrade in 2 weeks;this phenomenon became more appear in 4 weeks,nano-nacre powder degraded faster than micron-nacre powder,while the hole shadow was easy to be found;in 8 weeks,all the femoral holes recovered and returned to normal bone mineral density in all groups.Analysis of tetracycline fluorescent double marks in the hard tissue grinding slices indicated that new bone grew fastest around the bone defect area in study group,while most slowly in blank groupP＜0.05 SEM(scanning electron microscope observation showed that nano-nacre powder degraded more quickly.The same result can be found through the demineralized sections morphometric analysis,and both of the composite artificial bones made from those two kinds of nacre powder had the good connection with the adjacent tissue in rats body without apparent inflammatory response.5.X-ray photography showed that rabbit\'s bone defects healed faster in study group since NNAB implanted than in control group since MNAB implanted.At 24 weeks after operation,bone density in radial defects had nearly accessed to the normal area,while lower in control group,and turned up nonunion in blank group;The checking of BMD showed that results in study group were higher than those in control group at 8,16 and 24 week(P＜0.05), and the difference between the BMD values in study group at 24 week and those in blank group was not significant(P＞0.05).The gross specimens showed satisfactory histocompatibility both in study group and in control group,with bone tissue growing from two sides into the center of implanted materials; Normal slices in HE stain and hard tissue grinding slices in Stevenel\'s blue/Van Geison\'s picro-fuchsin stain showed that the bone growth tendency was better in study group than that in control group,and the medullary cavity had been penetrated to the implanted materials in study group at 24 week;Analysis of tetracycline fluorescent double marks in the hard tissue grinding slices indicated that new bone in both groups grew fastest 8 weeks after surgery,while slow down at 16 week.

纳米珍珠层/消旋聚乳酸复合人工骨与微米珍珠层/消旋聚乳酸复合人工骨分别与成骨细胞共培养后，其各时间点CCK-8法检测值与空白对照无显著差异(P＞0.05)，成骨细胞均在第5天达到增殖高峰期；培养7天后，实验组细胞蛋白含量高于对照组及空白组(P＜0.05)，后两者之间则无显著差异P＞0.05碱性磷酸酶活性在三组间均无显著差异(P＞0.05电镜下可见成骨细胞在两种人工骨上都有良好生长贴附能力。4.X-ray显示两种粉体在大鼠股骨骨洞植入第2周时都开始出现了降解，第4周时更为明显，纳米珍珠层粉较之微米珍珠层粉降解更快，而空白对照组骨洞阴影仍可见，至8周时，则所有组骨洞均己闭合修复，X-ray下已不可见原钻孔痕迹，恢复正常骨质密度；硬组织磨片四环素荧光双标记结果显示纳米珍珠层粉植入组较其余两组在骨缺损区周围新骨生长速度更快，空白组速度最慢P＜0.05电镜观察及常规脱钙切片亦可见到纳米粉体降解较快；由以上两种原材料制得的纳米珍珠层/消旋聚乳酸复合人工骨与微米珍珠层/消旋聚乳酸复合人工骨在大鼠体内均与周围组织结合良好，无明显炎症反应。5.X-ray显示纳米珍珠层/消旋聚乳酸复合人工骨植入兔桡骨缺损区后其骨愈合速度较对照组微米珍珠层/消旋聚乳酸复合人工骨植入的快，至植入术后24周，实验组骨缺损区接近正常骨密度，对照组骨缺损区密度较低，空白组则呈现骨不连状态；骨密度测量结果显示术后8周、16周、24周实验组的骨密度值高于对照组(P＜0.05，24周实验组的骨密度值与术前所测得的正常值无显著性差异P＞0.05动物取材大体所见均显示组织相容性良好，骨组织逐渐由植入材料两端向中央生长；常规切片HE染色及硬组织磨片Stevenel\'s blue/Van Geison\'s picro-fuchsin联合染色均可见实验组骨缺损区长势优于对照组，至术后24周，实验组骨髓腔与材料已呈相交通状；硬组织磨片荧光显微镜下观察，两组材料在术后8周处于骨生长最快速时期，16周时速度开始减慢，术后4、8、16周时实验组的新骨生长速度均较对照组的快

PartⅡThe mechanism elucidation about effects ofα-(2,3)/(2,6)sialic acid on the Cx43gap-junction functions.(1) Westernblotting experiment showed that the decrease of sialic acid didn\'t changethe Cx43 expression and its phospholation level.(2) Westernblotting experiment showed sialidase didn,t change the ZO-1 expression,IP and confocal experiment showed sialidase improved the interaction of Cx43 andZO-1.(3) Westernblotting experiment showed sialidase didn\'t change N-cadherin expression,IP and confocal experiment showed sialidase promoted the complex formation ofCx43 and N-Cadherin.(4)Sialidase could increase the ERK1/2 phospholation level,and enchanedintercellular homotypic adhesion,Immunofluorometric assay showed sialidase couldpromote the N-cadherin cluster on the membrance.

第二部分：α—(2，3)／(2，6)唾液酸对肿瘤细胞CX43间隙连接功能影响的机制研究1、Westernblotting结果表明降低细胞膜表面唾液酸并不改变Cx43的表达及其磷酸化水平：但Cx43连接斑形成增多；2、Westernblotting结果表明唾液酸酶作用后细胞ZO—1表达没有改变，IP及免疫荧光共定位结果表明唾液酸酶作用后促进了Cx43与ZO-1的结合；3、Westernblotting结果表明唾液酸酶作用后细胞N-cadherin表达没有改变，IP及免疫荧光共定位结果表明唾液酸酶作用后促进了Cx43与N-Cadherin复合物的形成；4、唾液酸酶作用后细胞内ERK1／2磷酸化水平明显增加，细胞间同质粘附增加，以及免疫荧光表明唾液酸降低后可促进N-cadherin的膜成簇。

Conventional MR showed supraspinatus abnormalities were two cases,MR arthrography showed supraspinatus abnormalities were four cases.Conventional MR showed Labral abnormalities were three cases,MR arthrography showed Labral abnormalities were six cases.Conventional MR showed capsule abnormalities were 0 cases,MR arthrography showed capsule abnormalities were four cases.Conventional MR showed bone abnormalities were eight cases,MRarthrographyshowedboneabnormalities were eight cases.

结果：8例中，常规MRI表现冈下肌腱异常者4例，MR关节造影表现冈下肌腱异常者7例；常规MRI表现冈上肌腱异常者2例，MR关节造影表现冈上肌腱异常者4例；常规MRI表现盂唇异常者3例，MR关节造影表现盂唇异常者6例；常规MRI表现关节囊异常者0例，MR关节造影表现关节囊异常者4例；常规MRI表现骨异常者8例，MR关节造影表现骨异常者8例。

Of the 14 SMAs, 11 (79%) showed low to intermediate density as compared with muscles, 3 (21%) showed homogenous and intermediate density; 12 (86%) appeared as lobulate lesions; 10 (71%) had incomplete bone septa; 9 (64%) showed root resorption of the neighboring teeth; 13 (93%) showed cortical perforation; 6 (43%) had soft tissue masses; all SMAs showed well-defined margins. Of the 11 SMAs examined by enhanced studies, 9 (82%) showed strong enhancement.

SMA病变中11例(79%)平扫时与肌肉相比呈等低混杂密度，3例(21%)呈较均匀等密度，12例(86%)边缘呈分叶状，13例(93%)骨壳被穿破，6例(43%)形成软组织肿块，但病灶的边界都清楚，10例(71%)见不全骨性分隔，9例(64%)邻近牙根被吸收，11例行增强扫描的病例中9例(82%)呈显著强化。

CT images of the 6 UAs showed homogenous and low density in comparison with muscles. Of the 6 UAs, 2 (33%) were lobulate, 4 (67%) were regularly round or oval; 1 (17%) had bone septa, 2 (33%) had root resorption of the neighboring teeth, 3 (50%) had cortical perforation. All UAs showed well-circumscribed margins without soft tissue masses. Three UAs were examined by enhanced studies and showed mild to moderate enhancement of the wall. Of the 5 MAs, 3 (60%) showed low to intermediate density as compared with muscles, 2 (40%) showed homogenous and intermediate density; 3 (60%) had bone septa; 3 (60%) showed root resorption or destruction of the neighboring teeth. All 5 MAs were lobulate with cortical perforation, soft tissue masses, and ill-defined margins. All 3 MA5 examined by enhanced studies showed strong enhancement. CONCLUSIONS: SMAs are usually seen in middle-aged patients.

UA病变平扫时与肌肉相比内部都呈均匀低密度，其中4例(67%)呈较规整的圆形或椭圆形，2例(33%)呈分叶状，3例(50%)局部骨皮质有缺损，但未见软组织肿块形成，l例(17%)见不全骨性分隔，2例(33%)邻近牙根有吸收，行增强扫描的3例囊壁均呈轻中度的强化。5例MA的病灶都呈分叶状，且骨皮质均被穿破并有软组织肿块形成，边界不清，其中3例(60%)平扫时与肌肉相比呈等低混杂密度，2例(40%)呈较均匀等密度，3例(60%)可见不全的骨性分隔，3例(60%)见牙根的吸收或破坏，行增强扫描的3例都呈明显强化。

Results Of the 21 patients, 5 showed transplanted kidney swelling alone, 8 showed transplanted kidney swelling and perinephric dropsy, 1 showed atrophy and function failure of both kidney, 2 showed perinephric hemorrhage, 1 showed multiple small cysts, small calculi and perinephric dropsy of transplanted kidney, 1 showed ureteral fistula, ureteral stricture, hydronephrosis and infarct of subsegment kidney, 1 showed hydronephrosis and ureteral calculi, 1 showed swelling and pyonephrosis, and 1 showed rupture of transplanted kidney.

结果 21例患者中5例仅表现为移植肾肿胀，8例表现为移植肾肿胀并肾周积液；1例为双肾萎缩伴功能丧失；2例表现为移植肾周积血；1例表现为移植肾多发小囊肿、小结石并肾周积液；1例表现为移植肾输尿管旁尿瘘伴输尿管狭窄及肾积水、亚段肾梗死；1例表现为移植肾积水并输尿管结石；1例表现为移植肾肿胀，肾盂内积脓；1例表现为移植肾破裂。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。