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Majority of acute leukemias in infant, either acute lymphoblastic leukemia or acute myeloblastic leukemia, posses a chromosomal translocation affecting the 11q23 chromosome region which specifically inoles the mixed-lineage leukemia gene.1-3 Most pediatric leukemias with MLL rearrangement clearly hae a remarkably short latency.1,4 MLL gene rearrangement is also associated with secondary leukemias of patients preiously treated with the topoisomerase II inhibitors.4 The latency of these secondary leukemias is similarly ery short.4 Of note, the concordance rate of leukemia with MLL rearrangement in infant monozygotic twins approximates to 100%,1,4 and identical breakpoint in the MLL gene was shared in these pairs of identical twin infants with concordant ALL.1,4 Moreoer, the unique and clonotypic MLL fusion gene was detectable in neonatal blood spots for Guthrie cards from non-twined indiiduals who subsequently deeloped ALL.1,4 These obserations indicate not only that MLL fusion is generated in utero but also that MLL fusion proteins could be capable of inducing leukemic transformation with few, if any, secondary mutations.2,3,4 Greaes et al speculate that an MLL fusion protein somehow promotes rapid transition to full-blown disease in patients ia ery rapid clonal expansion, genetic instability, or inhibition of DNA damage repair.4 In general, for clonal expansion of malignancies, tumor cells often hae acquired strategies that escape immune sureillance of the hosts.5,6 Immune escape mechanisms also contribute to the failure of graft-ersus-leukemia effect after allogeneic hematopoietic stem cell transplantation.7 Therefore, leukemia cells could acquire some immune escape mechanisms during leukemogenesis.

绪论 绝大多数的婴儿白血病,不管是急性淋巴性白血病或是急性骨髓性白血病,在染色体11q23部位有染色体易位的情况;这个部位的染色体易位牵连了混合谱系白血病基因。大多数具有MLL基因重排的儿童白血病潜伏期明显短很多。MLL基因重排也和经拓扑异构酶II抑制剂治疗后的继发性白血病有关。这些继发性白血病的潜伏期类似地都非常的短。很重要的是,单卵双胞胎婴儿同时患有或同时免于MLL基因重排阳性的白血病的一致性接近100%;并且同样患有ALL的同卵双胞胎的MLL基因的断裂点是一致的。而且,这种独特的克隆特异性的MLL融合基因能够从那些得ALL的非双生个体出生时的血斑标本中检测到。这些发现表明MLL融合基因产生在胎儿还在子宫的是后,而且MLL融合蛋白能过和其他的基因突变一起诱导白血病的产生。Greaes 等推测MLL融合蛋白在某种情况下同过快速克隆增殖,遗传的不稳定性或是DNA损伤修复的抑制促使疾病迅速地全面爆发。恶性肿瘤细胞的克隆增殖通常已经获得了逃避机体免疫监视的能力。免疫逃避机制也归因于异体外周血干细胞移植后移植物抗白血病作用的失效。所以,白血病细胞在白血病的产生过程中可能获得了某些免疫逃脱机制。

The results showed that bulb height and flower size of 'Large Copper' were least, with longest white short soft hair on stem. Obvious characteristics of 'Toronto' were nacarat and lackluster membranous bulb scales, leaves with rufous stripe and base of perianth shape and colour. Obvious characteristic of 'Pink Impression' were taller plantlet, bigger flower, taller and wider leaves and edge of leaves with short hair.

结果表明:品种Large Copper的种球高度和花径均最小,茎上白色柔毛最长;品种Toronto的显著特征是种球的膜质鳞片为桔红色,无光泽,叶片上有红褐色条纹,花被片基部为黑色舌形;品种Pink Impression植株高,花大,叶片长而宽,叶缘有短毛。

Reporter negundo only global financial tsunami, many countries and regions have more restrictions on short selling in Hong Kong over the past few days, many market participants have expressed the hope that the same prohibition of short selling activities in Hong Kong, the Hong Kong Government has no intention of implementing relevant measures.

全球金融海啸,许多国家和地区在香港的卖空更多的限制,在过去几天里,许多市场参与者都表示,希望在香港,香港的卖空活动一样,禁止政府没有执行有关措施的意图。

When two particles couple themselves in a singlet at short distances (one with spin up and one with spin down) the new nonlinear, nonlocal and nonpotential forces due to deep wave-overlappings are so attractive to overcome possible repulsive Coulomb forces, and permit new bound states at short distances which simply cannot be conceived - let alone treated - by quantum mechanics and chemistry.

当两个粒子在很小的作用距离内相互偶合成为零自旋态〔一个上旋而另一个下旋〕,深深重叠在一起的波导致新型的非线性、非局部和非潜势力的引力大到得以克服相互排斥库伦力,允许很小相互作用距离内的一种新的限制状态。量子力学和量子化学无法考虑,更不用说去处理,这种新的限制状态。

"In UK the nonserial drama, or the short series by a single writer, or the short series by different writers have provided more opportunity for distinguished writing."

在英国,单部电视剧和由一位或多位作者创作的短电视连续剧为杰出作品提供了更广阔的天地。

In the Okinawa population, nymphs developed faster under LD16:8h and LD14:10h than under LD 12:12h at constant photoperiods. When photopersodic shifts from long days (LD16:8h) to short days (LD 12:12h) at 60 and 120 days restrain nymphal development, while photoperiodic shifts from short days to long days accelerate the nymphal development.

冲绳种群在长日条件下(LD 16:8h)若虫发育显著快于中间日长(LD 14:10h)和短日条件下(LD 12:12h)的若虫发育,孵化后60d或120d将若虫自LD16,8h向LD 12:12h转移,若虫发育受到抑制,而自LD 12:12h向LD 16:8h转移,则促进若虫发育。

Male flowers: pedicel articulated at base; sepals 5, free, valvate, initially curved around stamens, later reflexed; petals and disk absent; stamens 5, free, inserted at bases of sepals; filaments short; anthers larger, thecae 2, parallel, introrse, dehiscence longitudinal; pistillode short and broad, peltate.

雄花 花梗有节在基部;萼片5,离生,镊合状,最初在雄蕊周围弯曲,后反折;花瓣和花盘无;雄蕊5,离生,着生在萼片的基部;花丝短;花药大,囊2,平行,内向,纵裂;退化雌蕊短和宽,盾形。

An aramid pulp predispersion with short fibre well-dispersed in rubber matrix was prepared by modifying the surface of the AP superfine short fibre with the proprietary AP pretreating technology.

采用芳纶浆粕预处理方法专利技术对芳纶浆粕超细短纤维表面进行改性处理,制备在橡胶基质中纤维分散性良好的芳纶浆粕预分散体。

Methods 150 patients with prostatitic of Ⅲa type were randomly divided into two groups. Patients in treatment group (n=75) were treated by combination of extraorgan short wave therapy (once 20 mins/day), wild chrysanthemum suppos.(a piece, once a day, take by anus) and controlled release tablets of Doxazosini Mesylas (40 mg, once a day). Patinets in control group (n=75) were treated by extraorgan short wave therapy.

将150例Ⅲa型前列腺炎患者随机分为2组,治疗组75例予体外超短波(每次20 min,每日1次)联合野菊花栓(每次1枚,每晚1次肛门给药)及甲磺酸多沙唑嗪控释片(每次4 mg,每晚1次睡前服)治疗,对照组75例单纯予体外超短波治疗。2组均14日为1个疗程,1个疗程后统计临床疗效和治疗前后慢性前列腺炎症状评分。

Sanctus. Mandibular fenestra expanded anteriorly. Maxilla protruding more anteriorly than in C. sanctus. Wing claw less developed. Sternum relatively elongate with a "V"-shaped anterior notch. Sternum with a pair of short posterior proceses. Tarsometatarsus relatively short. Pygostyle expanded distally.

上颌骨较圣贤孔子鸟向前突出,指骨爪没有圣贤孔子鸟那样伸长、强壮,胸骨比较拉长,前喙中央有一凹刻构造成&V&字形,同时胸骨两侧有一对短的后侧突,跗蹠骨较圣贤孔子鸟短,以及尾综合、骨末端膨大。

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The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应,而且减少跟风的可能性。

The new PS20 solar power tower collected sunlight through mirrors known as "heliostats" to produce steam that is converted into electricity by a turbine in Sanlucar la Mayor, Spain, Wednesday.

聚光:照片上是建在西班牙桑路卡拉马尤城的一座新型PS20塔式太阳能电站。被称为&日光反射装置&的镜子将太阳光反射到主塔,然后用聚集的热量产生蒸汽进而通过涡轮机转化为电力