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Also inhibits catecholamine secretion in intact and permeabilized chromaffin cells.

还抑制完整和透性化嗜铬细胞的儿茶酚胺分泌。

These experiments suggest that this dihydropyridinesensitive isoform of the mbC α1 subunit is functional in the transfected chromaffin cells and that the number of calcium channels is a limiting component in the secretion from chromaffin cells in culture.

这些实验结果推论这个小鼠脑中的对双氢吡啶敏感的mbC钙离子通道是L-型钙离子通道，并在转化的肾上腺嗜铬细胞中具有功能活性，而且说明钙离子通道的数目对培养的肾上腺嗜铬细胞的分泌是个限制因素。

The decrease of granule Ca content occurred earlier than the increase of epinephrine concentration, suggesting that the calcium released from chromaffin granule may in part account for the induced cell secretion.

激动剂作用引起的离体肾上腺髓质细胞分泌时颗粒内钙含量的下降早于颗粒数目减少或肾上腺素升高，提示颗粒释放的Ca2+可能是引起细胞分泌的原因之一。

Morphometry of numerical density and electron probe X-ray quantitative microanalysis were adopted to measure the alterations in the number and calcium content of chromaffin granules in adrenal medulla cells during the agonist treatment. Secretion of epinephrine was detected by the high performance liquid chromatography.

运用细胞立体形态计量法计算分泌过程中的嗜铬颗粒数目的变化，运用电镜X射线显微分析法测量分泌过程中嗜铬颗粒内钙含量的变化，并运用高压液相色谱分析法测定离体细胞在激动剂作用后的肾上腺素分泌情况。

A long-term persistence can strengthen the digestive system, inner secretion system, inner urinary system and excretory system to eradicate the constipation-caused distortion of nerve function from stomach and intestines, disturbance, facial spot, chromatosis of female.

本节目详细讲解了足部推拿调理便秘的主要手法和选取的反射区，长期坚持能增强消化系统、内分泌系统、泌尿系统和排泄系统的功能，消除便秘引起的胃肠神经功能紊乱、烦躁不安及女性面部色斑、暗疮、色素沉着等症状。

Afterwards of pelvic cavity abscess is sent at abdominal 2, palace antrum operation 1, celiac lens operation afterwards of 7 years old of little patients sends exemple of a;1 at acute appendicitis, abscess is formed all round appendix. 24 patients all have issue abdominal durative secret anguish or bilge painful, among them 18 have clonic aggravate, companion has frequent micturition, make water urgent, make water is painful wait for bladder to stimulate vagina of semiotic;10 exemple to shed secretion of yellow pus appearance, 5 have the vagina irregular bleed. 19 appear calorific of temperature 38~42 ℃, next 20 abdominal tenderness, bounce painful, flesh is nervous, the person that accessories division has touch a tender spot 22, among them side of 15 Yu Shuang, 7 touch at odd side bag piece.

盆腔脓肿继发于开腹手术2例，宫腔手术1例，腹腔镜手术1例；1例7岁患儿继发于急性阑尾炎，阑尾四周脓肿形成。24例患者均有下腹部持续性隐痛或胀痛，其中18例有阵发性加剧，伴有尿频、尿急、尿痛等膀胱刺激症状；10例阴道流黄脓样分泌物，5例有阴道不规则流血。19例出现发热(体温38~42℃)，20例下腹部压痛、反跳痛、肌紧张，附件区有触痛者22例，其中15例于双侧、7例于单侧触及包块。

FKZXKL has actions of anti-inflammatory, strenthening coagulatory,modulating sexual hormone and strengthening activity of uterus ,and could markedly change secretion of PGs The results of toxicolgy suggested FKZXIL is efficient and safe.

FKZXKL急慢性毒性实验结果表明，FKZXKL是一种低毒、安全有效的药物。

The study showed the recombinant wt/mCREG protein depressed the VSMC proliferation depending on dose and the optimal concentration was 400nM;2biologic function of CREG protein and the membrance receptor mechanism:①effect on VSMC migration: the wound healing experiment showed the OB2 cells migration was slower significantly after added wt/mCREG(400Nm) in supernatant. The HITASY cells migration were very slowly and no remarkable change. The gelatinase digestion and Western blot analysis showed the matrix metalloproteinase was decreased and TIMPs was increased;②effect on differentiation: after added wt/mCREG(400nM), the expression of myocardin, SMα-actin, MHC and caldesmin were increased and that of LM-1 and FN were decreased in OB2 cells. These effects were more significant when adding wtCREG.;③effect on VSMC proliferation: Cell cycle assay and BrDU stain showed: after added the wtCREG and mCREG protein, the ratio of cell in G0/G1 phase increased to 0.5773 and 0.5572 from 0.5308 respectively in OB2 group, which increased to 0.7369 and 0.7034 respectively from 0.6297 in HITASY group;3Role of M6P/IGF2R in CREG biologic function:①ELISA and co-immunoprecipitation showed the wt/mCREG binding to M6P/IGF2R directly.②antibody blocking test: when the anti-IGF2R was added to medium at the same time with wt/mCREG at different concentration(2μg/mL、4μg/mL、8μg/mL),the effects of CREG protein which depressing proliferation, migration, secretion and promoting differentiation were blocked, which had the positive correlation to the concentration of added anti body. The studies showed two combinant CREG promoted VSMC switch to differentiation phaenotype, at the same time, depress VSMC proliferation, migration and secreting extracellular matrix.

上述实验结果证实：两种重组CREG蛋白对VSMC增殖均有剂量依赖性的抑制作用，并且相同浓度的糖基化的CREG蛋白对细胞增殖的抑制效应更为显著，最佳效应浓度为400nM；2两种重组CREG蛋白添加后对HITASY和OB2细胞生物学行为的影响：①CREG蛋白对VSMC迁移的影响：刮伤实验发现，加入最佳效应浓度的wtCREG和mCREG蛋白24h后，OB2组迁移能力下降，HITASY组无明显变化；细胞外基质金属蛋白酶-2，9(Matrix metallo-proteinase 2，9，MMP2 ，9)明胶酶电泳检测和Western blot检测结果证实，两种CREG蛋白均可以使OB2细胞合成细胞外基质MMP2，9减少，而组织金属蛋白酶抑制物(Tissue Inhibitors of Metalloproteinases，TIMPs)增加；②CREG蛋白对VSMC分化的影响：加入400nM的wtCREG和mCREG蛋白12h后，OB2细胞myocardin、SMα-actin、MHC、caldesmin表达增加，LM-1、FN表达减少；③流式细胞仪分析细胞周期和BrDU染色分析证实，加入400nM的wtCREG和mCREG蛋白后，OB2组G0/G1期细胞由0.5308分别增加至0.5773和0.5572，HITASY组G0/G1期细胞由0.6297分别增加至0.7369和0.7034；3M6P/IGF2R在重组CREG蛋白的生物学功能中的调控作用：①免疫共沉淀和免疫荧光双染色分析结果显示，CREG蛋白与M6P/IGF2R存在直接结合；②应用抗体阻断实验：将不同浓度的anti- M6P/IGF2R(2、4、8μg /mL)与两种CREG蛋白同时加入培养液中，CREG蛋白抑制VSMC增值、迁移和合成细胞外基质、促进分化的效应减弱，而且与加入anti- M6P/IGF2R浓度正相关。

Simvastatin may exert its function to prevent allograftangiopathy by the mechanism of cholesterol-lowering, the increase expression ofeNOS and secretion of NO, direct anti-inflammatory effect, commissural inhibitionwith cyclosporine on MHC-II and CD4~+ T cells.

他汀类药物可能通过降低血胆固醇水平、促进eNOS 的表达并增加NO 的分泌、直接的抗炎作用、与环孢素联合抑制MHC-II 的表达和T 淋巴细胞的活化增殖等机制来对抗同种异体血管硬化的作用。

After transplantation, all the defects in the two groups were covered by hyaline cartilage. Tidal lines were concinnous and the chondrocytes were arrayed orderly with a plenty of secretion of cartilage matrix. In the allograft group, there were tiny fissures observed in the deep layer of cartilage and bone beneath at the location of transplantation.

两组移植后，兔关节缺损处被透明软骨覆盖，潮线整齐，细胞排列有序，分泌大量基质，异体移植组移植处软骨深层及软骨下骨处可见微小裂隙，未见淋巴细胞和浆细胞浸润。

For a big chunk of credit-card losses; the number of filings (and thus charge-off rates) would be rising again, whether

年美国个人破产法的一个改动使得破产登记急速下降，而后引起了信用卡大规模的亏损。

Eph. 4:23 And that you be renewed in the spirit of your mind

弗四23 而在你们心思的灵里得以更新