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Results(1) Insulin secretion and mRNA levels of PDX1 were significantly decreased in rats with Type 2 diabetes meilitus compared with the control group.(2) Compared with the diabetic group, insulin secretion and mRNA levels of PDX1 were significantly increased in the medium and high dose of arecoline groups.

结果：（1）高糖作用引起Wistar大鼠胰腺β细胞PDX1 及胰岛素mRNA 的表达水平显著下降（P＜0.01）；（2）1 mg/kg和5 mg/kg槟榔碱处理能显著上调高糖喂养Wistar大鼠胰腺β细胞PDX1与胰岛素mRNA表达水平（P＜0.05，P＜0.01）。

Promoting bile secretion ebony enable cholecystokinin, promoting bile secretion and excretion, the medicine for the treatment of bile duct ascariasis

促进胆汁分泌乌梅能够使胆囊收缩，促进胆汁分泌和排泄，为治疗胆道蛔虫症之良药

It is reported that after the female enters the menopause, because the ovarian function starts to decline, the secretion female, the progestogen reduced, causes the skin to have a series of changes, like some person skin elastic fibers thinning, easy to break; Some person hair becomes withered, easy to lose hair; Some people present the fixed spot or the whole body skin pruritus; Some people have the dermal sensation to be unusual, like the numbness, the needle grip or creeps; Some people present the mucous membrane to be dry, the eye is colored in the very short time endomorphism, has the dust or the sense at present; Some person nasal cavity, the oral cavity mucous membrane withers, the mouth does frequently, always wants to drink water; Some person vagina mucous membrane withers, the secretion reduces, affects the sex life quality.

据介绍，女性进入更年期后，由于卵巢功能开始衰退，分泌的雌、孕激素减少，导致皮肤产生了一系列的变化，如有的人皮肤弹力纤维变细，易断裂；有的人头发变得干枯、容易脱发；有的人出现固定部位或周身皮肤瘙痒；有的人出现皮肤感觉异常，如麻木感、针扎或蚁行感；有的人出现黏膜干燥，眼睛在很短的时间内变花，眼前有灰尘或异物感；有的人鼻腔、口腔黏膜萎缩，经常口干，总想喝水；有的人阴道黏膜萎缩，分泌物减少，影响性生活质量。

Increases of APP transcript and expression by HupA also contribute to the up-regulation of sAPPα secretion. Meanwhile, Aβ secretion was observed to decrease 2 h after HupA treatment, and after 24 h incubation, HupA can significantly inhibit the secretion of Aβ.

Real-time PCR和Western blotting结果提示石杉碱甲能增加APP的转录和表达，该作用也将有助于对sAPPα分泌的上调；同时Aβ的生成并未相应增加，ELISA检测结果显示石杉碱甲孵育2 h后即能对Aβ分泌产生抑制作用，孵育24 h后能显著降低Aβ水平。

Cd〓 (1, 10, 100, 1000μM) stimulated directly GtH secretion from pituitary of common carp in vitro, with the highest GtH secretion at 100μM, GtH secretion stimulated with 1000μM Cd〓 was not higher than that stimulated with 100μM Cd〓.The antagonism between Ca〓 and Cd〓 in perfusion of the pituitary fragments was not obvious.After being preperfusion with 100μM Cd〓(with or without Ca〓), the GtH secretion of the pituitary fragment was irresponsive to 2-min pulse stmulation of 10μM sGnRH-A.

鲤鱼脑垂体碎片离体灌流孵育实验结果显示，Cd〓（1，10，100，1000μM）可直接刺激鲤鱼脑垂体分泌GtH，灌流液中Ca〓对Cd〓的拮抗作用不明显，100μM Cd〓刺激脑垂体分泌GtH达到高峰，Cd〓浓度增加到1000μM时，脑垂体分泌GtH并没有进一步增加，甚至有减少的趋势；100μM Cd〓预灌流脑垂体后，可使脑垂体对2-min 10μM sGnRH-A刺激的反应性消失；1.25mM的EDTA可消除100μM Cd〓刺激脑垂体分泌GtH的作用；TFP和Cd〓同时灌流脑垂体一段时间后，撤除TFP可使脑垂体分泌GtH显著增加，即出现"反跳"现象。

Insulin secretin response to glucose challenge in vitro showed the mean value of insulin in the low-glucose medium was 39.74±2.73mM, while that of high-glucose medium was 128.94±8.72mM, the SI was 3.25±0.26, that means the islets functioned well. The releasing insulin levels of the nine groups responding to 16.7mM glucose at the end of 24h and 48h: At the end of the first 24h, the controlssecretion were similar in two phases, while the G group has increasing tendency;As for oleate groups, the base secretion have no difference,while the stimulated secretion was descending;As palmic acid as concerned,both base and sitimulated secretion was descending(p＜0.01) accompany with the elevated glucose.

在培养48h后油酸组刺激后时相分泌量减少(p＜0.05)；软脂酸组两时向差别显著(p＜0.01)各组细胞在16.7mM葡萄糖刺激5min时的胰岛素mRNA表达：在培养24h及48h后，葡萄糖对照组胰岛素mRNA表达组间无明显差别(p＞0.05)；油酸组培养24h胰岛素mRNA表达组间无明显差别(p＞0.05)，培养48h后mRNA表达组间比较存在统计学差异(p＜0.05)；软脂酸组培养24h时胰岛素mRNA表达量下降(p＜0.05)，培养48h后胰岛素mRNA表达量下降明显(p＜0.01)。

It improves the quality of meibomian gland secretion and stimulates aqueous tear secretion by repairing tear secretion in dysfunctional lacrimal glands and decreasing lacrimal gland apoptosis.

它提高质量，睑板腺分泌，并刺激水性泪液分泌修理泪液分泌失调泪腺和降泪腺凋亡。

Methods test 1 256 samples from suspect uu or ct sufferers and infertile patients during 2007.results the positive rate of uu of 149 samples of prostate liquid is 42.3%(63/149), and the positive rate of ct of 136 samples of prostate liquid s is 19.9%(27/136);the positive rate of uu of 361samples of the secretion of the urinous tract is 21.1%(76/361),and the positive rate of ct of 346 samples of the secretion of the urinous tract is 10.4%(36/346);the positive rate of uu of 141 samples of semen is 11.3%(16/141),and the positive rate of ct of 123 samples of semen is 7.3%(9/123).conclusion there are significant differences in positive rate of uu and ct of 3 types of samples p.005.the positive rate of specimens of postate liquid is higher than that of the secretion of the urinous tract ,the positive rate of semen test is the lowest..the results from the uu and ct test of different types of specimens are different obviously .the most suitable specimen of test is prostate liquid.

对2007年1 256例怀疑感染uu或ct的患者和不孕不育症患者标本检测。结果：149例前列腺标本中uu阳性率为42.3%(63/149)、136例前列腺标本ct阳性率为19.9%(27/136)；361例尿道分泌物uu阳性率为21.1%(76/361)、346例尿道分泌物ct阳性率为10.4%(36/346)；141例精液uu阳性率为11.3%(16/141)、123例精液ct阳性率为7.3%(9/123)。结论：三种标本的uu、ct阳性率相差显著，p.005。前列腺标本检测的阳性率明显高于尿道分泌物标本，精液检测的阳性率最低。不同类型的标本检测的uu、ct的结果有很大的差异，送检的标本最好是前列腺液。

In exceptional circumstances, a dream to the delicious food, will stimulate saliva secretion, saliva secretion increased, it will lead to drooling; improper sleeping positions sometimes lead to the phenomenon of flow of saliva; Some people sleep regularly teeth and stimulate the brain nerve center, to promote saliva secretion, so that flow of saliva; some people love spicy food thing, or, tobacco, liquor, so that night, dry mouth, increased saliva secretion; sleep, mouth breathing tends to dry mouth, thus contributing to an increase in saliva secretion ; In addition, some diseases, such as infectious stomatitis, toothache, mercury, potassium iodide poisoning, but also can stimulate an increase in saliva secretion, causing sleep drool.

是对美食的梦想，会刺激唾液分泌，唾液分泌增加，会导致流口水，有时睡觉姿势不当导致的唾液流现象，有些人睡眠定期牙齿和刺激大脑神经中枢，促进唾液分泌，使唾液流动，有些人喜欢吃辣的东西，或者，烟，酒，所以这天晚上，口干，唾液分泌增加，睡眠，口呼吸往往口干，从而促进在唾液分泌增加，此外，如传染性口腔炎，牙痛，汞，碘化钾中毒的一些疾病，而且还可以刺激唾液分泌增加，造成睡眠流口水。

But it in 10"8mol/L-10"mol/L inhibited gastrin secretion .whereas it promoted somatostatin secretion of duodenum in vitro. GnRH-A did not effect significantly gastrin and somatostatin secretion of stomach in vitro.These results suggested that GnRH-A may integrate with GnRH receptor and restrain directely gastric acid secretion in parietal cell.

综上所述，我们认为胃腔内的Gn尺H类似物可能首先和壁细胞上GnRE受体结合，直接抑制壁细胞胃酸的分泌，由于胃酸分泌减少反馈性地刺激胃泌素细胞，促进其合成及分泌胃泌素，胃酸分泌减少同时也反馈性的抑制生长抑素的释放，反馈性地抑制胃肠壁内EC细胞分泌5一HT。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。