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Objective: To explore the mechanisms resulting in the recurrence of urethral scar which make urethral strictures difficult to be cured, a series experiments were conducted to find potential effective factors involved in urethral scar formation and degradation, including the studies of extracellular matrix component of urethral stricture scar, the characteristics of urethral scar fibroblast, and the effects of urine on urethral fibroblast in vitro, as well as the studies to compare the difference of collagenase activity, type Ⅰ collagen and tissue inhibitor of metalloproteinase-1 (TIMP-1) in the tissues and cultured fibroblasts from normal urethra and strictured urethra respectively, and the studies to investigate the effect of antisense TIMP-1 oligodeoxyonucleotide on cell proliferation and collagenase activity of urethral scar fibroblast.

中文题名尿道瘢痕基础研究副题名胶原酶活性,TIMP-1的表达及其反义基因治疗外文题名 Experimental study on urethral scar-activity of collagenase,expression of TIMP-1,and antisense TIMP-1 gene transfection of urethral scar fibroblast 论文作者黄翔导师杨宇如教授学科专业外科学研究领域\研究方向学位级别博士学位授予单位四川大学学位授予日期2002 论文页码总数104页关键词尿道手术瘢痕胶原酶成纤维细胞尿道瘢痕馆藏号BSLW /2003 /R699 /12 目的:研究尿道瘢痕的细胞外基质的组成,尿道瘢痕成纤维细胞的生物学特性以及尿液对其生长的影响;比较胶原酶活性,金属蛋白酶组织抑制因子-1(TIMP-1)以及Ⅰ型胶原含量在尿道瘢痕和正常尿道组织及体外培养的成纤维细胞中的差异;研究反义TIMP-1寡核苷酸对尿道瘢痕成纤维细胞增殖以及胶原酶活性的影响。

Methods Cut the scar along it's length with operation knife to form a scar-skin which thickness is of about 0.8~1.2mm,then cut off the scar tissues under the scar-skin,replant the scar-skin in the same place,enswathed the wound with proper pressure.

沿瘢痕纵轴在瘢痕内切口,手术刀锐性剥离,形成0.8~1.2mm厚的瘢痕皮,切除瘢痕皮下的瘢痕组织,将瘢痕皮原位回植,适当加压包扎。5~10天拆线,应用肤康霜或硅酮霜3~6个月。

Methods The design of burn scar flaps in tendo calcaneus was improved. In virtue of accessary transverse incision, ankle joints were reposited, without incision or free liberation of the internal side's scar flap.Results Improved scar flaps in tendo calcaneus met the need of ankle joints' functional reposition with an additional benefit that internal scar flaps were not prone to necrosis.

对跟腱瘢痕瓣进行改良设计,不切开内侧瓣内缘切口,内侧瘢痕瓣不游离,借助辅助横切口,将踝关节复位,同时观察早期烧伤创面的不同处理方法和伤后至手术时间的长短对功能复位的影响。

Eliminate the scar-free surgery: a variety of traumatic scars left by old or new scar bump, body parts, size, a maximum of 20 days treatment effect could be seen clearly, with a total has more than 90% efficiency; all of the scars resulting from burns, scar tissue lesion prominent extravasated blood swelling, joint adhesion traction, twin reduction, pigmentation, stasis purple, white spot, no surgery and skin grafting, simply tie in with the scrubbing liquid, the effect of scar will be a miracle.

免手术祛除疤痕:各种创伤留下的凹凸疤不分新旧疤痕、身体部位、面积大小、最多治疗20天都能见到明显效果,总有效率达90%以上;所有烧烫伤后造成的疤痕、患处组织增生性疤痕突出、红肿淤血、关节粘连牵拉、孪缩、色素沉着、淤血紫红、白斑,不用手术及植皮,只需配合擦洗液,疤痕的效果会出现奇迹。

Dermatological Treatment: Burns, keratosis, acne, melasmas, chloasma, lentigines, warts, psoriasis, carcinoma, hypertrophic scar, hypercronic scar, retractable scar, surgical scar, keloids.

皮肤科治疗:烧伤,毛囊角化症,痤疮, melasmas ,黄褐斑, lentigines ,疣,牛皮癣,癌,增生性疤痕, hypercronic疤痕,可伸缩疤痕,手术疤痕,瘢痕疙瘩。

The present invention shrinks the tissue in the heart (10) by selectively heating infarcted scar in order to reduce the size of the surface of the infarcted scar, make the soft part of the scar tissue become rigid, reduce the wall tension of shrinking the ventricle, and increase the total pump efficiency of the infarcted heart (10) by removing ventricle aneurism.

本发明通过有选择地加热梗塞瘢痕,收缩心脏(10)中的组织以缩小瘢痕组织表面积(18)的大小、使瘢痕组织的松软部分变硬、减少心室收缩的壁张力,并通过消除心室动脉瘤来增加梗塞心脏(10)总泵送效率。

Has entered the flowering period of strong ginkgo tree, spur on the shape of the three can be seen traces of traces of the bud scales linear scar, kidney-shaped scar that leaves marks, circular scar is spent stalk marks.

已经进入开花结实期的银杏树,短枝上可以见到三种形状的痕迹;线形痕是芽鳞痕,肾形痕是叶痕,圆形痕是呆柄痕。

Weeks after MSC implantation, Scar area index (scar length to left ventricular circumferences of the endocardium and epicardium) and the scar thickness is measured by computer-assistant planimetry as character of myocardial remodeling.

将自体骨髓基质细胞植入大鼠心肌梗死区,8周后通过图象分析仪测定疤痕指数,梗死区厚度和边缘区心肌细胞直径以了解移植MSC对左室重构的影响。

Results:The positive rates of TSP- 1 mRNA in hypertrophic scars and keloid were lower than those in normal skin and surgical scar. MVC was higher in the cases with negative expression of TSP - 1 mRNA than the ones with positive expression of TSP - 1 mRNA. MVC was higher in the hyperstrophic scar and keloid than in normal skin and surgical scar.

结果TSP-1 mRNA在增生性瘢痕和瘢痕疙瘩中表达的阳性率低于在正常皮肤和外科瘢痕组织中的表达(P<0.05);TSP-1 mRNA表达阴性病例组的MVC显著高于TSP-1 mRNA阳性病例组的MCV(P<0.05);增生性瘢痕和瘢痕疙瘩组织中微血管数多于正常皮肤和外科瘢痕组织的微血管。

RESULTS: Psilotic scar eliminated in all cases, but 11 cases underwent scalp scar excision, transposition of local flap and autologous hair transplant because of wide incisional scar or residual small alopecia.

结果:全部病例均能消除秃发的瘢痕,术后11例因切口瘢痕过宽或残留小面积秃发区,行头部瘢痕切除、局部皮瓣转位、自体毛发移植等治疗后修复,无明显并发症发生。

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According to our present broadcasting situation,the thesis proposes using new technology to update and reform the present HFC. It also suggests broadcasting using self-advantage and arranging EPON in order to win the supermarket.

论文从我国广电的现状出发,结合实际,积极倡导采用新技术更新、改造我国现有的HFC网络;倡导广电现阶段利用自身优势,部署EPON网络来赢取市场。

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But with the development of industry, the proletariat not only increases in number; it

但是,随著工业的发展,无产阶级不仅人数增加了,而且它结合成更大的集体,它的力