查询词典 sarcosine

The first aim of this project is to examine the efficacy, safety, and cognitive effects of sarcosine monotherapy in schizophrenic patients, and, to identify the clinical predictors for better response to sarcosine.

本研究的首要目的即在探讨单独使用sarcosine对於精神分裂症患者之疗效、安全性及对认知缺损的效果，并找寻对於sarcosine反应较佳之临床预测因子。

Expected Results: We hypothesize that sarcosine monotherapy will be not inferior to risperidone in efficacy for positive and negative symptoms, and be superior in side effect profiles and cognitive effects.

预期结果：我们预期sarcosine对於精神分裂症活性、负性症状的疗效不亚於目前广泛使用之新一代抗精神病剂risperidone，且具有更佳的安全性及促进认知功能之效果。

In the future, double blind, placebo controlled trials comparing the clinical efficacies between sarcosine and an SRI, in combination with genetic studies focusing on the glutamatergic neurotransmission, is suggested.

未来可以进行双盲对照研究比较sarcosine与SRIs的疗效，并收集个案周边血液测试其基因型和治疗前后基因表现、并结合神经影像学研究，以进一步了解麸氨酸神经传导在强迫症之致病因与治疗的意义。

Nine psychiatric outpatients aged between 20 and 63 with a primary diagnosis of OCD had completed 10 weeks' treatment with sarcosine. Five of them received sarcosine as mono-therapy and 4 of them as an adjuvant to their current SRIs therapies.

九名完成试验之受试者包括单独服用sarcosine者五名（三名曾用过血清素回收抑制剂，两名从未用过药物治疗），sarcosine合并使用中的SRIs者四名。

Result: Y-BOCS scores improved significantly over time in two drug-nave patients and a patient with combination treatment. There was no significant improvement in Y-BOCS scores in patients who failed more than 2 standard treatments with SRIs. For responders, the time intervals to achieve criteria of response (more than 35% decrease of Y-BOCS scores) were within 2 weeks of sarcosine treatment at relatively low dose.

在使用过或维持SRIs治疗之个案，sarcosine之疗效则不一致：并用SRIs治疗四位中，两位血清素回收抑制剂顽抗型(SRIs-refractory)个案对sarcosine无明显疗效；另一位并SRI治疗个案在用药两周内强迫症状即有明显改善，但在服药剂量减少两周后症状恶化。

The patients with lower serum glycine or D-serine levels, more severe negative symptoms and cognitive deficits, abnormal expression in mRNA or protein levels of certain genes (e.g., lower expressions of SHMT2, PSAT1 and serine racemase; higher expressions of AMT and ASCT1) may be more likely to respond to sarcosine.

此外，用药前具有较低的血清glycine或D-serine浓度、较明显的负性症状或认知功能缺损、以及特定基因於mRNA或蛋白质层次表现异常(如：SHMT2、PSAT1及serine racemase表现较低，而AMT及ASCT1表现较高)的患者，可能对sarcosine有较佳的治疗反应。

To date, there have been a few clinical trials exploring the efficacy of NMDA enhancers as adjuvant therapy. For instance, D-serine (an endogenous agonist of the NMDA-glycine site) and sarcosine (N-methylglycine, an endogenous glycine transporter I inhibitor) are not only well-tolerated but also synergistic in improving positive, negative symptoms and cognitive function in chronic patients receiving typical or atypical antipsychotics. We just completed the first trial applying NMDA enhancers in acutely exacerbated schizophrenia patients with collaboration with Harvard University, and the results showed that sarcosine was superior to D-serine in efficacy.

目前已有将NMDA促进剂作为辅助用药的临床研究，例如，D-serine (一种内生性NMDA-glycine site致效剂)、sarcosine (即N-methylglycine，一种内生性glycine transporter I 抑制剂)等，结果显示它们不但安全，且能加强传统及新一代抗精神病剂对慢性患者活性、负性症状及认知功能的疗效；我们日前与哈佛大学合作完成目前唯一将NMDA促进剂用於急性患者的研究，结果发现，sarcosine的疗效又优於D-serine。

Sodium lauroyl sarcosine was used as a denaturant, a novel protein refolding method, which was proposed on the basis of one step-AMC and IEC, one step-AMC-IEC was used on the refolding of denatured/reduced lysozyme.

一步人工分子伴侣-离子交换色谱法辅助还原变性溶菌酶的复性：以月桂酰基肌氨酸钠(Sodium Lauroyl Sarcosine，Sarkosyl，SLS)作为蛋白变性剂，发展了一步人工分子伴侣-离子交换色谱法，对还原变性溶菌酶进行了复性研究。

Ve schizophrenic inpatients will be enrolled into the 6-week, randomized, double-blind trial of sarcosine monotherapy (1000~3000 mg/day, N=75) vs. risperidone (2~6 mg/d, N=75). We will measure clinical efficacy and side effects biweekly during the treatment. At the beginning and the end of the trial, we will also measure cognitive function (e.g. intellect, attention, memory, executive function), serum amino acids, expressions of mRNA (by realtime quantitative RT-PCR) and protein of NMDA-related genes (such as SHMT2, AMT, PSAT1, ASCT1, and serine racemase) in peripheral blood lymphocytes.

第一部份将收案150位未曾治疗之精神分裂症住院患者，以双盲方式随机给予六周sarcosine (1000-3000 mg/day，N=75)或risperidone (2-6 mg/day，N=75)治疗，我们将每两周评估临床疗效与安全性，并在研究开始及结束时，评量认知功能(智能、注意力、记忆力、执行功能)并测定血清中glycine或D-serine浓度以及SHMT2、AMT、PSAT1、ASCT1、serine racemase等基因於周边淋巴球之mRNA (以realtime RT-PCR测定)与蛋白质表现量。

In this paper, firstly using natural fatty acids including lauric acid, myristic acid, palmitic acid etc. and disproportionated rosin as starting materials, the acyl reaction of starting materials with SOCl_2 respectively, and then using Schotten-Baumann condensation: on the reaction conditions of alkalescence, condensation of acylchloride with amino acid (sarcosine, glycine, alanine etc.), and then acidification, saltation. A series of anionic surfactants of N-acyl amino: sodium N-fatty acyl sarcosinate (SFS-12, SFS-14, SFS-16); sodiun N-fatty acyl glycinate(SFG-12, SFG-14, SFG-16); sodium N-fatty acyl alaninate(SFA-12, SFA-14, SFA-16)and sodium N-disproportionated rosinoyl aminatewere prepared. During the preparation of N-acylamino acid, the reaction conditions of acylchloride with amino acid condensation were identified by optimizing the synthetic conditions of N-lauroyl sarcosine: mol ratio of amino acid to acylchloride 2:1, reaction taken place in a solvent composed by acetone/water 2:1, acylchloride and 20% NaOH were slowly added to the reaction mixture at the same time while maintaining the pH at 9~10, after completion of adding maintaining reacting for 2.5h at 25℃.

首先以月桂酸、肉豆蔻酸、棕榈酸等天然脂肪酸和歧化松香为原料，与氯化亚砜反应制得酰氯，然后采用Schotten-Baumann 缩合法路线，即在碱性条件下，酰氯和氨基酸(肌氨酸、甘氨酸、丙氨酸等)缩合，经过酸化、成盐，合成一系列氨基酸型阴离子表面活性剂：脂肪酰肌氨酸钠，即月桂酰肌氨酸钠(SFS-12)、肉豆蔻酰肌氨酸钠(SFS-14)、棕榈酰肌氨酸钠(SFS-16)；脂肪酰甘氨酸钠，即月桂酰甘氨酸钠(SFG-12)、肉豆蔻酰甘氨酸钠(SFG-14)、棕榈酰甘氨酸钠(SFG-16)；脂肪酰丙氨酸钠，即月桂酰丙氨酸钠(SFA-12)、肉豆蔻酰丙氨酸钠(SFA-14)、棕榈酰丙氨酸钠(SFA-16)；N-歧化松香酰基氨基酸钠(sodium N-disproportionated rosinoyl aminate)，即N-歧化松香酰基肌氨酸钠(sodium N-disproportionated rosinoyl sarcosinate ，简称SDRS)、N-歧化松香酰基甘氨酸钠(sodium N-disproportionated rosinoyl glycinate，简称SDRG)、N-歧化松香酰基丙氨酸钠(sodium N-disproportionated rosinoyl alaninate，简称SDRA)。

They weren't aggressive, but I yelled and threw a rock in their direction to get them off the trail and away from me, just in case.

他们没有侵略性，但我大喊，并在他们的方向扔石头让他们过的线索，远离我，以防万一。

In slot 2 in your bag put wrapping paper, quantity does not matter in this case.

在你的书包里槽2把包装纸、数量无关紧要。