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The 20S catalytic core of the 26S proteasome has the shape of a barrel made of four rings which are composed of seven differentαsubunitsα_1-α_7 at two outer rings and seven differentβsubunitsβ_1-β_7 at two inner rings at which the catalytic sites locate. Three of theβsubunits contain proteolyses sites, which are sequestered in the hollow interior of the 20S particle. Substrates enter the 20S through a narrow channel formed by theβsubunits, whose N-termini, depending on their conformation, can either obstruct or allow substrate entry and thus function as a gate. This entry channel is narrow and only permits passage of unfolded, linearized polypeptides.

哺乳动物26S蛋白酶体是由一个20S催化颗粒(catalytic particle,CP)和两个19S调节颗粒(regulatory particle,RP)组成的ATP(adenosine-triphosphate,ATP)依赖性蛋白水解酶复合体。20S CP是26S蛋白酶体的催化核心,它是由4个圆环堆叠形成的桶状复合物,其中两侧外环每个环是由α_1-α_7亚基组成,两个内环每个环是由β_1-β_7亚基组成,4个环的中央形成一个狭窄的内腔。2个β内环形成了20S CP的催化中心空腔,其内壁为催化活性位点所在地;外侧α环中心的孔道是底物到达催化中心空腔的通道,一般被α亚基上的N末端所封闭,阻止胞内非目的靶蛋白进入20S CP内被降解破坏。

Due to the inspiration of maximal injective module by professor Wang Ming-yi, in chapter two, we introduce the conception of max-projective modules, discuss its properties, applications: the primitive relations between rings and endomorphism rings, an equivalence that is surrounding strongly V.N. rings.

受汪明义教授引进极大内射模概念的启发,在第二章中我们引进了极大投射模的概念,由此讨论了它的一些性质及其应用:环与自同态环之间的本原性关系;强正则环的一个等价刻划;并在环为交换和非交换的情形下分别应用有限表现模的极大投射性得出了SF环和Von Neumann正则环的关系。

In this chapter, firstly, the definition of rough rings and its properties are given. Then the definition and properties of rough subrings, rough ideals and rough quotient rings are put forward and proved. Finally, homomorphism and isomorphism of rough rings is studied.

在这一章中,首先给出了粗糙环的定义及其性质,其次给出了粗糙子环、粗糙理想、粗糙商环的定义及其性质,最后研究了粗糙环的同态与同构。

The theory of rings is an important content of Modern Algebra, while the polynomial rings is an important part of the rings. Polynomial ring is similar with power series ring, and it is a subset of the power series.

摘要环论是近世代数中的重要内容,而多项式环的性质又是环论理论中的重要组成部分,多项式环是幂级数环的子环且与幂级数环形式相近。

II, Polynomial rings on a general field( on contrast of those over a number field): concepts of ring, ideals, field and several special rings as domains, principal ideal domains and unique factorization domains, the unique factorization theory of polynomial rings.

二、一般域上的多项式理论(是数域上多项式理论的推广):学习环、域和几类特殊结构的环(整环、主理想环,唯一分解环等)的概念,多项式环的唯一分解定理;三、线性代数:讲述一般数域上的向量空间理论(是数域上向量空间理论的继续和推广),模的概念,主理想环上的模的结构及其线性变换的若当标准型等;四、一元多项式的解及域论:学习域扩张及其相关概念,伽罗瓦理论,用伽罗瓦定理判断根式解的存在性。

In this dissertation, we establish the fundamental theory and methods to study systems of linear matrix equations over regular rings and polynomial rings over finite central algebras; and investigate some significant systems of linear matrix equations over the rings mentioned above.

本文在正则环和有限维中心代数上的多项式环上初步建立了研究矩阵方程组的基本理论和方法,并在上述环上研究了具体的具有重要意义的矩阵方程组。

In the third chpter, we combine local rings with semiregular rings and strongly π-regular rings, respectively.

我们除了对这两类环的性质作了一定的研究之外,还把一部分局部环和半正则环、强π正则环的结果推广到这两类环上。

It is well known that semiregular rings and strongly π-reguar rings are both semi-π-reguar rings.

众所周知,半正则环和强π正则环都是半π正则环。

Effects of H_2O_2 on the tension of isolated aortic rings of rat As above methods,Our results indicated that (1) aortic rings with endothelium precontracted by NE to 10000μmol/L H_2O_2 induced a relaxation; aortic rings with endothelium to 100μmol/L H_2O_2 induced a significant contraction;H_2O_2 induced the same effects in aortic rings without endothelium, there is significant difference in presence and absence of endothelium.

双氧水对大鼠离体血管环张力的影响方法同2,结果:①NE预收缩后,加入10000μmol/L H_2O_2,内皮完整血管环表现为舒张作用;加入100μmol/L H_2O_2后血管环表现为收缩作用;H_2O_2对去内皮的血管环同样具有上述作用,与内皮完整组相比差异显著;②10000μmol/L H_2O_2可使得内皮完整及去内皮血管环中NO含量升高;100μmol/L H_2O_2可使得NO含量降低。

The practical application of HVD in Liaohe Oilfield shows that castiron piston rings wear rapidly if they are designed according to JB/T 8547-97, and the piston rings made of PTFE have long working life. Leakage is permitted to some extent in rotating seal in HVD, consequently, O rings can work for about 1 month instead of piston rings and can be used when urgent.

通过在辽河油田注水泵的现场运行表明,根据JB/T 8547-97设计的铸铁涨圈磨损快,而采用填充聚四氟乙烯材料的涨圈寿命长;根据HVD旋转密封允许一定泄漏的特点,采用O形圈代替涨圈也可获得约1个月的使用寿命,可作短期应急使用。

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歌手leona刘易斯和前率领的飞艇的吉他手吉米页出现巴士转化为基层所涵盖的嘉年华花车,和一双合并为一移交&整个lotta爱&。

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