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If they occur, the Pharmacopeial and NDA impurity limits and rationale should be reviewed; the limits should be revised when indicated to ensure similar or improved quality of the drug substance.

如果发生变化,应检查药典和NDA杂质限定和原理;为确保原料药的相似或改善质量时,应修改限度。

The general chapter 5.10 of the European Pharmacopoeia "Control of impurities in Substances for Pharmaceutical use" and the revised general monograph 2034 Substances for pharmaceutical use introduce new requirements (as also described in the guideline CPMP/QWP/1529/04 Control of impurities of Pharmacopoeial substances) that should be consulted to understand how to read the limits of the monograph and how to apply the general monograph when setting specifications.

欧洲药典总章5.10&药用物质中杂质的控制&和修改后的总论2034药用物质介绍了新的要求(在指南CPMP/QWP/1529/04 药典物质中杂质的控制),应参考这些新的要求,弄明白如何读专论的限度,以及在设定质量标准中如何使用总论。

All of the polypore names were checked or revised in accordance with the contemporary taxonomy and the latest version of the International Code of Botanical Nomenclature.

对中国多孔菌的名称按新近研究成果和最新命名法规进行了订正。

In the meantime, the Whig Government in England had fallen and, in 1841, the new Tory Foreign Secretary, Lord Aberdeen, issued revised instructions to Pottinger, dropping the demand for an island.

其时,英国的维新党政府下台,新上任的保守党外务大臣阿巴甸勋爵于一八四一年修改给予砵甸乍爵士的训令,撤回割地的要求。

Firstly, the predesign is carried out by use of the conventional analysis, and then the acceleration curve of the cam driven component is processed and revised discretely according to the requirements of dynamics performance.. The design equation based on a Refined Finite-Difference Algorithm is established and the calculating process is realized by the computer programs. Consequently, the cam profile with good performance can be attained.

该方法先用常规解析法作初步设计,根据动力性要求对从动件加速度曲线进行离散化处理和修正,再用有限差分法建立凸轮型线的设计方程式,通过计算机程序进行计算求解,因而可以获得优良性能要求的凸轮型线。

A revision method of unsatisfied elements and the simple computing formula for the revised Priorly valued are given.

基于一致性均衡权指标,提出了一种排序方法和一种不满意元素的识别方法,给出了不满意元素的调整方法和修正排序权值的简单计算公式。

Then, suggestions were put forward: prevention first, integration of family planning program efforts, and three pronged strategy, which were originally raised by James D Shelton of US and revised by the writer to adapt to the social reality of China.

希尔顿的艾滋病预防策略:预防为主的方针、计划生育系统的介入和三个目标群体宣传策略。

The college students are tested of Cognitive Style Analysis.It was studied to the revised test and psychometrical quality test,. and passed attempt to delimit of cognitive style.

以大学生为对象,对&认知风格分析测验&(Cognitive Style Analysis,CSA)进行了项目分析、信度、效度检验等一系列研究,并通过大学生样本划界尝试。

Applying soil's nonlinear stress-stran relationships (the skelton curve adopts Hadin's hyperbola model and the loaded/unloaded curve adopts the Masing's law revised by Pyke), and taking the viscous boundary as flank artificial boundary, 2D dynamic analysis of the foundation is programed by FEM. It contains an automatic dividing-element subroutine. It could be employed to calculate the horizontal and vertical seismic responses of the soil and foundation.

本文按照土体的非线性应力—应变模式,即将Hadin的双曲线模式作为骨架曲线,加卸荷采用Pyke等修正的广义Masing二倍法则,采用粘性边界作为侧面人工边界,用八结点等参数有限元法在微机上编写了二维地基的动力分析程序,该程序含有网络自动剖分模块,能较好地模似地基和基础在水平方向和竖向的地震反应。

Personality traits were evaluated by Eysency Personality Questionnaire that was compiled by Eysency and revised by Gong. Standard scores of Psychoticism, Extraversion and Neuroticism were calculated, and taking 50 points as a boundary. Each dimension was assigned into 2 grades non-psychotic type (P0) psychotic type (P≥50), introversion type (E0), extraversion type (E0), non-nervous type (N0) and nervous type (N≥50). 5 mL ulnar vein blood was obtained without adding decoagulant, and then serum was removed. Genome DNA was extracted from blood clot by conventional chloroform for PCR analysis. PCR product was sequenced by pyrophosphoric acid. SNP was determined by PSQ96 MA sequenator. Allele frequency was analyzed by mass spectrometry.

人格评定采用Eysency编制,龚耀先修订的艾森克人格问卷、计算精神质,内外问,神经质3个个性维度的标准分,并以50分为界,将各维度分为两个等级:非精神病倾向型(精神质0)、精神病倾向型(精神质≥50);内倾型(内外向0),外倾型(内外向≥多50);非常经质倾向型(神经质0),神经质倾向型(神经质≥50)取肘静脉血5 mL,不加抗凝剂,弃血清,血凝块常规酚氯仿提取基因组DNA,进行PCR分析PCR产物应用焦磷酸测序PSQ96 MA测序仪进行SNP检测,用质谱法进行及等位方基因频率分析。

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Singer Leona Lewis and former Led Zeppelin guitarist Jimmy Page emerged as the bus transformed into a grass-covered carnival float, and the pair combined for a rendition of "Whole Lotta Love".

歌手leona刘易斯和前率领的飞艇的吉他手吉米页出现巴士转化为基层所涵盖的嘉年华花车,和一双合并为一移交&整个lotta爱&。

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