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The amphiphiles, 4-8, can not form reverse bilayers in organic solvent, which result in that the molecular interactions unable to meet the need for hydrophile-lypophile balance, so that they crystallize and exhibit no gelling abilities. The mono-chained L-alanine derivatives, 1-3, can self-assemble into bilayer aggregates, through intermolecular hydrogen bonding and homochiral effect in a number of organic liquids, which are juxtaposed and interlocked by van der Waals interaction, and finally gelate the organic liquids.

单链酰基化L-丙胺酸两亲物1-3在一些低极性的有机溶剂可以通过分子间氢键相互作用及同手性聚集作用形成有序的反双分子膜结构，这些有序反双分子膜结构单元依靠vander Waals力相互作用可以平行排列且相互之间进行连结形成长纤维状的聚集体，纤维状聚集体在有机介质中可以进一步相互连结形成三维网状结构，进而胶凝有机溶剂。

The compounds of the invention are also useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system, such as neurodegenerative diseases, The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the hydroxamic acid derivatives in vivo.

本发明的化合物还可用于预防和治疗TRX-介导的疾病，例如自身免疫性、变应性和炎性疾病，并且用于预防和/或治疗中枢神经系统疾病，例如神经变性性疾病。本发明还提供了包含所述异羟肟酸衍生物的药物组合物以及这些药物组合物的易于依从并且在体内产生治疗有效量的所述异羟肟酸衍生物的安全剂量方案。

The evidences from neuroanatomy, neurophysiology, especially recently from neuropsychology and neuroimaging studies of OCD suggest that: the functional overactivities in OFC and ACC could be responsible for the increased functions of error recognition and evaluation of emotion and motivation; the functional hypoactivity in DLPC could result in the lack of cognitive integration of the consequence of action.

来自神经解剖、神经生理以及近期神经心理和功能成像等的相关研究证据显示：OCD病人眶额皮层、前扣带回皮层的过度激活可能会导致错误识别功能和对行为结果预期的情绪与动机评价增高；背外侧前额皮层的活动减弱损害了对信息加工的认知整合能力。

Comparative studies of electroactive components and voltammetric behaviors different between the MCF-7 cell without estrogen and the MCF-7 cell with estrogen showed that the concentration of the guanine and xanthine bases in the cytoplasm decreased, which resulted in the decrease of secretion ability of the MCF-7 cell without estrogen decreased, and these result in the decreasing of the voltammetric response of the cells, impling that the cell vaibility decreases.

结果发现，去激素MCF-7细胞质中的黄嘌呤和鸟嘌呤浓度降低，使细胞分泌黄嘌呤和鸟嘌呤能力降低，导致细胞和细胞质的伏安信号减弱，说明去激素MCF-7细胞的活性下降；研究了标准雌激素雌二醇、环境雌激素壬基酚和双酚A对去激素培养的MCF-7细胞增殖的影响，发现其均存在剂量-效应关系和时间-效应关系，并且雌激素效应由大到小的顺序为：雌二醇＞壬基酚＞双酚A；同时使用3-(4，5-Dimethylthiazol-2-yl)-2，5-diphenyltetrazolium bromide法验证了电化学法评价雌激素效应的可靠性。

Despite the fact that deterministic relationships are used in most compiterized models for engineering,the model outputs are indeterministic due to the uncertain and stochastic nature of the model inputs and parameters. All the uncertainty may contribute to the stochsticity of the input parameters of a corresponding model which, in turn, result in output uncertainty.

尽管大部份工程应用电脑模式均以定率式的物理关系作为基础，但引用电脑模式进行设计，必须考虑隐含在模式输入与控制参数的不确定性，及其所产生模式输出的不确定性。

Kyphotic deformity due to the fractures may progress over time and result in late neurologic compromise.11,14,15,27 However the true percentage of cases with intravertebral vacuum with neurologic involvement cannot be determined accurately, since neurologic deficit was encountered in 100% of the patients in a series with open surgery,11,14,15,27 whereas in series with minimally invasive procedures neurologic compromise was not present.

骨折可能逐渐产生后凸畸形，并导致迟发性神经症状[11，14，15，27]，但椎体内真空现象伴有神经症状的比例还没有一个准确的数字，在常规开放性手术的病例系列中100％伴有神经症状[11，14，15，27]。

Traumatic or surgical injuries to this system can cause leakage of lymph and result in the formation of a lymphocele, which is defined as an accumulation of lymph surrounded by pseudomembranes (layers of tissue with a reaction of the surrounding tissue).10 Lymph drainage above the cisterna chyli is rich in chylomicrons and has a creamy white appearance because of the contribution of the gastrointestinal lymphatics.14 Below the cisterna chyli, however, lymph is serous in nature and has a clear yellow color and a significantly lower triglyceride content.

外伤或手术对这个系统造成损伤可以引起淋巴漏，最终导致淋巴管瘤形成。淋巴管瘤即为有假膜（由于四周组织反应形成的组织层）包裹的淋巴聚集。由于胃肠道淋巴的关系，在乳糜池以上的淋巴管富含乳糜微粒，有奶油样的白色外观。而乳糜池一下的淋巴则为浆液性质，为清亮黄色，其甘油三脂的含量明显降低。

Result In 5 kinds of chemical treatments, treating Z. macrostachya seeds with 20 % NaOH solution for 20 min and then cleaning the seeds with clear water got the best effect of breaking seed dormancy. By this treatment, the seed germination potential reached 83.5% in 10 d, being 58.2 % higher than CK; reached 85 % in 15 d, being 55 % higher than CK, which was near to the potential germination rate of Z. macrostachya seeds. Compared with CK, the germination duration was obviously shortened.

结果］在5种化学处理中，用浓度20%NaOH溶液处理大穗结缕草种子25min，再用清水清洗，对解除种子休眠效果最佳，10d发芽势达83.5%，比对照高出58.2百分点，15d发芽率达85%，比对照高出55.0百分点，已接近大穗结缕草种子的潜在发芽率，发芽历时比对照明显缩短。

Some problems exist in the traditional protection method: it may perform maloperation in time of power swing; the existence of transition resistance may result in tripping missing or maloperation.

但是距离保护的性能也存在一些问题：当系统发生振荡时距离保护可能会误动作，过渡电阻的存在可能会使距离保护误动或拒动等等，这些对距离保护的性能有很大的影响并且难以避免。

Result:In immobilized and control hindlimbs, the mean ROM of the knee were 79.5°and 138.5°, respectively. The gain of ROM after myotomy in immobilized and control hindlimbs were 8.7°±0. 45°, 11.6°+0.58°, respectively. Only 14.75%of the limitation of motion in ROM were accounted for by the myotomy component.

结果：制动侧和对照侧膝关节的ROM分别为79.5°和138.5°，行肌肉切断术后其ROM分别增加了8.7°±0.45°，11.6°±0.58°，肌源性成分在关节挛缩中所占的比例仅为14.75％。

In the negative and interrogative forms, of course, this is identical to the non-emphatic forms.

。但是，在否定句或疑问句里，这种带有"do"的方法表达的效果却没有什么强调的意思。

Go down on one's knees;kneel down

屈膝跪下。。。下跪祈祷