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At the IV dose of 20 and 30 mg/kg, Aloin and Isobarbaloin result appear the mean terminal eliminate half-life(T1/2 β)were 54.1±28.4; 28.7±18.3 and 36.9±21.9;49.7±17.1 min, respectively. The mean area under the serum concentration curve(AUC0-∞)were about 411.655± 13.027;318.213±19.924 and 701.336±116.631;573.278± 86.870μg min/mL, respectively. The mean drug clearancewere 0.165±0.011;0.214±0.016 and 0.149±0.030;0.182±0.035 L/min, respectively.

若静脉注射剂量20和30 mg/kg后,其芦荟大黄苷及异芦荟大黄苷分别平均末端排除半衰期(T1/2 β)为54.1±28.4;28.7±18.3和36.9±21.9;49.7±17.1 min,平均稳定状态分布体积为7.668±3.155;6.343±3.522和5.146±2.490;8.525±2.683 L,平均曲线下面积(AUC0-∞)为411.655 ±13.027;318.213±19.924 和701.336±116.631;573.278±86.870 μgmin/mL,平均血浆中药物最高浓度为23.920±5.669;30.442 ±7.537和57.920±27.690;36.373±14.174 μg/mL,平均药物之清除率为0.165±0.011;0.214±0.016和0.149±0.030;0.182±0.035 L/min。

At the IV dose of 20 and 30 mg/kg, Aloin and Isobarbaloin result appear the mean terminal eliminate half-life(T1/2 β)were 54.1±28.4; 28.7±18.3 and 36.9±21.9;49.7±17.1 min, respectively. The mean area under the serum concentration curve(AUC0-∞)were about 411.655± 13.027;318.213±19.924 and 701.336±116.631;573.278± 86.870μgE min/mL, respectively. The mean drug clearancewere 0.165±0.011;0.214±0.016 and 0.149±0.030;0.182±0.035 L/min, respectively.

若静脉注射剂量20和30 mg/kg后,其芦荟大黄苷及异芦荟大黄苷分别平均末端排除半衰期(T1/2 β)为54.1±28.4;28.7±18.3和36.9±21.9;49.7±17.1 min,平均稳定状态分布体积为7.668±3.155;6.343±3.522和5.146±2.490;8.525±2.683 L,平均曲线下面积(AUC0-∞)为411.655 ±13.027;318.213±19.924 和701.336±116.631;573.278±86.870 μgEmin/mL,平均血浆中药物最高浓度为23.920±5.669;30.442 ±7.537和57.920±27.690;36.373±14.174 μg/mL,平均药物之清除率为0.165±0.011;0.214±0.016和0.149±0.030;0.182±0.035 L/min。

The linear ranges of the calibration curves for lycorine, lycoramine and galanthamine were 5.0-400 mg/L, respectively. Their detection limits were 5.0, 5.1 and 10.2 ng, respectively and the RSD were 2.2%, 5.7% and 4.4%, respectively.

采用三乙胺水溶液(pH9.0)-乙腈-甲醇作为流动相对石蒜碱、力可拉敏和加兰他敏进行HPLC测定,方法的线性范围为5.0~400mg/L,检出限分别为5.0、5.1、10.2ng, RSD分别为2.2%、5.7%和4.4%。

Of planted seedlings and conserved seedlings/saplings, 51.6% and 60.7% survived respectively. Thirteen months later, the seedling heights of Ficus septica, Mallotus repandus, Maacaranga tanarius, Melanolepis multiglandulosa, and Broussonetia kaempferi, and those of Hibiscus tiliaceus, Acacia confuse, and Mellettia pinnata increased more than 130 cm and 50 cm, respectively. The densities of the planted seedlings and conserved seedlings/saplings were 1610 and 680 per hectare, respectively. On the other hand, the density of Leucaena seedlings significantly decreased; and the height of Leucaena stayed steadily during the 13 months.

试验分经银合欢药剂注射处后,采用原生树苗下栽植及保天然新苗木方式进相旧,期间经过2次植栽周边除草抚育作业,栽植苗木及天然新苗木在13个月后之存活分别为51.6及60.7%,密分别为1610株/ha及680株/ha,其中果榕、扛香藤、血桐、虫屎、构树之苗高平均生长在130 cm以上,黄槿、相思树、水黄皮之苗高平均生长在50 cm以上;相对的,银合欢新幼苗在分经药剂处前之平均高为12.3 cm,密为236,000株/ha,药剂处后13个月,幼苗平均高为15.0 cm,幼苗密低至43,000/ha。

Among the cases, hypergranular promyelocytic was present in 15%. Infected bone marrow and megaloblastic anemia were observed in 5% respectively. Fungi infected bone marrow and idiopathic thrombocytopenic purpura were found in 2.5% respectively. Pure red cell aplasia and granulocytic series deficiency due to regenerative granulocyte failure were observed in 2.5% respectively.

在40例艾滋病患者中,反应性早幼粒细胞增多者占15%,感染性骨髓象和巨幼细胞性贫血各占5%,真菌感染性骨髓象和特发性血小板减少性紫癜各占2.5%,纯红再障和生成减少性粒细胞缺乏症各占2.5%。

Results In vitro recovery of the probe was mainly influenced by the perfusion rate. When the perfusion rate was set at 1.0μL/min, in vitro and in vivo recoveries of the probe were 50.16±2.34% and 14.096±0.58%, respectively. The enhancement indexes for 3%, 5% mentha oil were 3.8 and 17.6, respectively. The enhancement indexes were 9.2 and 24.8, for 3% and 5% of Azone, respectively. Conclusion The steady sate flux of meloxicam in rats is significantly improved by enhancer mentha oil and azone.

结果: 在实验条件下微渗析探针的体外回收率主要受灌注液流速的影响,为(50.16±2.34)%;反向渗析法测得探针的在体回收率为(14.096±0.58)%;MO的体积分数为3%和5%时,增渗倍数分别为3.8,17.6;azone的体积分数为3%和5%,增渗倍数分别为9.2,24.8;结论:不同体积分数的MO和azone均可显著增加美洛昔康经皮渗透稳态流量,azone的体积分数为5%时,大鼠角质层的屏障作用可能受到了较大程度的破坏。

The elimination half-life t(subscript β1/2 was 161.10h, 333.21 h and 611.26h, respectively, and the total body clearance was 27.4mL/, 16.8g/ and 18.0g/, respectively. The metabolite ciprofloxacin concentration-time profiles of the plasma, muscle and liver presented similar trend. The multi- peak phenomenon were observed in the plasma, muscle and liver, but the first peak time was 24h, 24h and 12h, respectively. The peak residue of metabolite ciprofloxacin was in liver, muscle and plasma, ordinally. The eliminating rate of ciprofloxacin from muscle and liver was very low.

代谢物环丙沙星在鳗鲡血浆、肌肉和肝脏中药物水平的变化趋势与恩诺沙星基本相似,呈现出多峰现象,但3种组织中环丙沙星出现第一个药峰时间分别为给药后第24小时、24小时和12小时,3种组织中环丙沙星峰值水平肝脏中最高、肌肉中次之、血浆中最低,环丙沙星在肌肉和肝脏中的消除速率比较缓慢。

Accordingly, the Q bands of them blue shifted by 6mn and 13nm, respectively. The fluorescence emission wavelengths of Cd-pheophytin a and Cd-pheophytin b observed at 660nm and 649nm, respectively, which were shorter than those of corresponding pheophytin a and pheophytin b by 10nm and 9nm, respectively.

研究发现:在光吸收性质上,与脱镁叶绿素a和b相比,镉叶绿素a和b在Soret带的吸收峰位置分别红移了19nm和11nm,而在Q带则分别蓝移了6nm和13nm;在荧光性质上,镉叶绿素a和b的荧光发射波长比脱镁叶绿素a和b分别蓝移了10nm和9nm。

Results The linear ranges of tanshinol sodium and protocatechualdehyde were 42.52~382.68μg/mL and 8.14~ 73.30μg/mL, respectively; the correlation coefficients were 0.999 8 and 0.999 6, respectively; the average recoveries of spiked sample were 100.54%(RSD=0.797%) and 98.87%(RSD=1.282%), respectively.

结果丹参素钠在42.52~382.68μg/mL浓度范围内线性关系良好(r=0.999 8),平均回收率为100.54%(RSD=0.797%);原儿茶醛在8.14~73.30μg/mL浓度范围内线性关系良好(r=0.999 6);平均回收率为98.87%(RSD=1.282%);结论此法简便,快速,准确。

Results:There were 30 patients with systemic sclerosis (42.2%),10 with Sjogren′s syndrome(14.1%),6 with systemic lupus erythematosus (8.5%),5 with rheumatoid arthritis and localized sclerosis (7.0%) respectively,4 with only Raynaud′s phenomenon without any definite diagnosis (5.6%),2 with CREST syndrome,overlap syndrome,cirrhosis of unknown causes and buerger′s disease (2.8%) respectively,and 1 with primary billiary cirrhosis,sclerous cholangitis,and chloasma-vitiligo (1.4%) respectively.

结果:ACA可在多种疾病中出现,其中系统性硬化症30例(42.2%),干燥综合征10例(14.1%),系统性红斑狼疮6例(8.5%),类风湿关节炎5例(7%),局限型硬皮病5例(7%),仅有雷诺现象但诊断不清者4例(5.6%),CREST综合征、重叠综合征、不明原因肝硬化、闭塞性脉管炎各2例(2.8%),原发性胆汁性肝硬化、硬化性胆管炎、黄褐斑合并白癜风各1例(1.4%)。

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