查询词典 repressor

Chloromycetin had positive effect on BADH gene expression, and the effect might be due to inhibit repressor generation in mitochondria and activate transcription factor of BADH gene.

应用氯霉素的实验表明氯霉素对BADH基因表达为正效应，提出了可能是抑制了线粒体中的阻遏蛋白的产生使BADH基因表达去阻遏。

The regulatory elements of the tetracycline resistance operon of Eschenchia coli, Tet repressor and Tet operator, have served as the basis for the establishment of heterologous repression-based inducible system in many eukaryotes including yeast, plants, insects, mammals and parasitic protozoa, such as Trypanosomes, Entamoeba, Giardia, Toxoplasma, Leishmania and Trichomonas.

基于四环素抑制子(Tetracycline Repressor，TetR)和四环素操纵子(Tet Operator，TetO)相互作用的四环素可诱导转基因表达系统，已经广泛的应用于很多真核生物，包括酵母、植物、昆虫、哺乳类细胞和诸如锥虫、阿米巴、贾第虫、弓形虫、利什曼和毛滴虫的寄生原虫。

Repressor proteins are produced by a regulator gene but they are unable to bind to the operator in their normal conformation.

阻遏蛋白质会由调控基因所产生，但它们却不能够与操纵基因结合。

However, repressor makes an additional contact with the other face of DNA.

但是，抑制子与DNA 的另一面还有附加的反应。

From that day forwards all Orders were given access to the Repressor.

从那时起，所有的教团开始装备镇压者。

The repressor is essentially a negative control mechanism.

阻遏物基本上是一种负控制机制。

A small molecule that binds to a repressor protein to allow repressive activity.

结合到阻遏蛋白上使其产生阻遏活性的小分子。

The regulation of gene expression is to have relations to the assembly of the DNA binding proteins which bind to DNA to initiate the transcription. Some of these proteins have the ability to promote bending or looping of DNA. The FIS protein regulates gene expression in Escherichia coli by this property of bending DNA. There are many researches to discover the mechanism of FIS protein binds to DNA. However the experiment data only show the supposititious results and figure out the model of FIS-DNA complex structure. This research uses molecular dynamics simulation to compute the detail of the interaction between FIS and DNA. We observed FIS prominently affects the DNA bending by the type of local bending. Analyzing the DNA structure properties, roll and slide, also demonstrates the local bending type and region. The hydrogen bonds between FIS and DNA are analyzed to compare with the experiment data. Finally we compute the binding free energy between FIS and DNA to estimate the result of simulation and compare with the value of λ-repressor-DNA complex.

基因的表现与结合於DNA促使DNA转录作用起始的DNA结合蛋白组装有关，一些这类的蛋白质具有促使DNA扭曲或将DNA形成环状的能力，FIS蛋白质即是藉由扭曲DNA的特性调控大肠杆菌基因的表现，目前已有很多的研究发现FIS与DNA结合的机转，然而这些实验的数据仅能显示推测性的结果，进而利用这些结果推论出FIS与DNA聚合体结构的模型，本研究利用分子动态模拟的方式计算FIS与DNA交互作用的细节，我们观察到FIS主要影响DNA的扭曲方式为DNA区域扭曲的类型，并且分析DNA结构特性roll与slide也指出扭曲方式为区域扭曲与其扭曲的区域，我们也分析FIS与DNA之间的氢键，并且与实验的资料作比较，最后我们计算FIS与DNA之间的结合自由能评估模拟的结果，并且计算出的值和λ-repressor与DNA聚合体结构的实验值作比较。

So, to study the mechanism of phynotype transition is an important aspect to provent hyperplasic vascular desease.In 1998, Gill's study showed the cellular repressor of E1A-stimulated genes could promote cell differentiation and maturity. Also, CREG might effect on the maintenance of cellular differentiation status.

因此，对VSMC表型转化机制的研究是增生性血管病防治研究的一个重要方向。1998年，Gill等研究提示，人E1A激活基因阻遏子基因(cellular repressor of E1A-stimulated genes， CREG)可以诱导细胞的分化和成熟，并参与成熟组织中细胞分化状态的维持。

I. Design and selection of thc high affinity DNA ligands for singIe-chain reprcssorSingle-chain repressor RRn., is a derivative of bacteriophage 434 repressor,which contains covalent1y dimerized DNA-binding domains (axnino acids 1-69) of thephage 434 repressor.

一。设计和筛选单链阻遏蛋白的高亲和力DNA结合序列单链阻遏蛋白RR_是噬菌体434阻遏蛋白的衍生物，它是噬菌体434阻遏蛋白的N端DBD（1—69位氨基酸）组成的共价二聚体。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。