查询词典 replication

They foundthat BMV 1a cooperates with two other viral elements--an enzyme known as 2apolymerase and an RNA sequence called a replication signal--to sequester thevirus's genetic material in compartments called spherules.

他们发现：BMV 1a与另外两个病毒成分－一个叫做2a的聚合酶和一个叫做复制信号的RNA序列合作

Objective: To obtain the replication-defective retrovirus.

目的 为了获得通用型逆转录病毒载体。

In previous studies, during replication of the Streptomyces linear replicons the discontinuous synthesis of the lagging strands will leave a gap on the 3' end of the DNA.

先前的研究发现当链霉菌进行线型DNA复制时，由於在lagging strand的非连续性复制导致在3'端留下一缺口。

In the comparison between genotypes, it was found that 1b-NS5As exerted more profound inhibitory effects on IFN activity than 2a-NS5As. The replication of the 2a-NS5A-containing replicons was more sensitive to IFN treatment than that of the 1b-NS5A-containing replicons. By domain swapping, we found the V3 and the C-terminus regions were responsible for the differential anti-IFN effects between genotypes.

我们并收集了共十五名分别感染基因型1b及2a的HCV患者样本，比较两基因型来源的NS5A蛋白质对IFN的抑制效果，结果发现来自基因型1b的NS5A蛋白质确实会比来自基因型2a的NS5A蛋白质具有更强大的IFN拮抗效果。

We used the hepatitis C virus subgenomic replicon cell system to evaluate the effect of ethanol on HCV replication and viral protein synthesis.

我们用丙型肝炎病毒亚基因复制子模型，来评估酒精对丙型肝炎病毒的复制和病毒蛋白合成的影响。

It is why the methods of science that emphasize checking and rechecking, verification and replication, and especially attempts to falsify a claim, are so critical.

这就是为什么科学方法强调检验和反复检验，证实和重复，特别是对理论的证伪非常关键。

To understand the infectivity by porcine endogenous retrovirus with porcine skin fibroblast cell in vitro and in vivo, porcine skin fibroblast cell established by our laboratory were co-cultured with neo/HEK293 cell for the infection of RERV in vitro, and were subcutaneously transplantated to SCID (severe combined immuno-deficiency) mice for the infection of PERV in vivo, laying the foundation for valuation of biologic safety of xenotrans-plantation. The event of neo/HEK293 cells infected by PERV occurred during co-culture of porcine skin fibroblast cells with neo/HEK293 cells, expanding the rang of the infection of porcine endogenous retrovirus. Afterpig cells transplantated subcutaneously in SCID mice, the microchimerism (78.57%) of pig cells occurred widel, and there was phenomena of integration of PERV provirus (85.71%) in several organs or tissues remote from the injected sites, indicating infection of PERV in SCID mice in vivo. yet, there is no evidence of active viral replication in analysis of PERV env RNA of these tissues or organs.

为了解猪皮肤成纤维细胞PERV在体外和体内的感染性，通过建立猪皮肤成纤维细胞系，将所建细胞系与人胚胎肾293细胞体外共培养，并移植于严重联合免疫缺陷鼠皮下进行猪皮肤成纤维细胞PERV的体外和体内感染性实验，结果表明，猪皮肤成纤维细胞与人胚胎肾细胞共培养过程中，猪内源性逆转录病霉感染人胚胎肾细胞，进一步证实和拓宽了猪细胞PERV感染人细胞的范畴；猪皮肤成纤维细胞移植SCID鼠皮下后，导致SCID鼠发生猪细胞微嵌合(78.57%)和PERV在体内感染(85.71%)并且波及远离移植部位的多种组织或器官，但是并未检测出SCID鼠组织中表达PERV env RNA。

Integrase is a viral enzyme that is essential for HIV type 1 (HIV-1) replication; it catalyzes the insertion of proviral DNA into the host-cell genome.

整合酶是HIV-1病毒用来进行自身复制的重要酶；它能够催化前病毒DNA插入宿主细胞染色体中。

The EIAV proviral genomic long-terminal repeat is a eukaryotic promotor, which plays an important regulatory role on transcription and replication of the virus.

反转录病毒前病毒基因组长末端重复序列对病毒复制有重要的调控作用，影响到病毒的繁殖动力学、组织嗜性、致病力等方面。

HIV-1 integrase catalyzes the integration of proviral DNA into the genome of the host cell, an essential step for viral replication, thus inhibition of integrase catalytic activity represents a rational strategy for the treatment of HIV-1 infection.

HIV-1整合酶催化前病毒DNA整合进入宿主细胞基因组的过程是病毒复制必不可少的步骤，所以抑制HIV-1整合酶活性是治疗HIV-1感染的合理策略。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。