查询词典 remission

Background and objective Although marked progress has been made in the treatment of acute myeloid leukemia,about 20%～40% patients with AML failed to get complete remission after standard induction chemotherapy. Furthmore, approximate 70% patients in CR will die because of relapse or refractory to therapy during post remission chemotherapy.

研究背景及目的：尽管目前急性髓系白血病(acute myeloid leukemia，AML)的治疗取得了显著的进步，但仍有20％～40％的患者经标准诱导治疗未能达到完全缓解(complete remission，CR)，即使获得CR的患者，在巩固化疗后仍有70％左右复发或发展为难治性急性髓系白血病而治疗无效死亡。

The patients achieved complete remission after induction course would enter the next grouping:the patients,aged 15-45 years, who had suitable donors and transplantation will were assigned to allogeneic stem-cell transplantation,and for the rest,they would be assigned to accept chemotherapy or autologous stem-cell transplantation randomly.CT and ASCT group both received early intensification and consolidation therapy orderly,which contained high-dose methotrexate,intermediate/high-dose cytarabine and high-dose or high-fraction cyclophosphamide,followed by ASCT or re-induction,later consolidation and maintenance chemotherapy for CT group.

符合入组条件的成人非Ph+ALL患者纳入研究，患者接受标准VDCP±L诱导治疗达到完全缓解(complete remission，CR)后进入下一阶段分组研究：年龄≤45岁，有合适供者及移植意愿者接受异基因造血干细胞移植allogeneic stem cell transplantation，Allo-SCT其余患者根据意愿分别接受自体造血干细胞移植(autologous stem cell transplantation，ASCT和化疗Chemotherapy。

Results: Among the 9 patients, two achieved completely remission, 2 achieved partial remission, 1 improved and 2 had no effect. The total response rate was 59%(5/9). The side effects were drowsiness, constipation, and debility.

结果：56%(5/9)的患者对治疗有效，其中2例为完全缓解，2例部分缓解，1例进步，2例无效；患者出现不同程度的嗜睡、便秘、头晕、皮疹等副作用。

The results showed that allergic response, diabetes and drug-induced liver disease happened more frequently during maintenance therapy than during remission induction therapy, while defibrination, abnormal hemaglutinin, acute pancreatitis, hypoproteinemia, gastrointestinal reaction and infectious shock were observed more during remission induction therapy than those at maintenance therapy.

结果表明：过敏反应、高血糖症及药物性肝炎的发生率在维持期加强治疗的ALL患儿高于诱导缓解期患儿，而低纤维蛋白原血症、凝血异常、胰腺炎、低蛋白血症、胃肠道反应及合并感染性休克等副作用在诱导缓解期患儿中发生率高。

The most commonly used drugs Bleomycin, mitomycin C, Adriamycin, 5 - 5-fluorouracil (5 - Fu), methotrexate, cyclohexyl - nitrosourea, imipramine hydrazone, Vindesine, etoposide (VP-16), chlorine and ammonia-platinum, a single chemotherapy drug remission rate in the 15% to 20% remission for 1 to 4 months.

最常用的药物有博来霉素、丝裂霉素C、阿霉素、5-氟尿嘧啶（5-Fu）、甲氨喋呤、环己亚硝脲、丙咪腙、长春花碱酰胺、鬼臼乙叉甙（VP-16），以及顺氯氨铂，单一药物化疗的缓解率在15％～20％，缓解期为1～4个月。

ResultsRenal remission achieved in six of 10 patients （60%）, partial remission in three, and unresponsive in one to LEF treatment. Gastrointestinal reaction occurred in two patients, allergy in one, transient leucopenia in one.

结果 共有6例（60%）缓解，3例部分缓解，1例无效。2例出现胃肠道反应，1例发生过敏反应，1例发生一过性白细胞下降，未见肝功能异常。

Methods Thirey-two patients treated by a regimen of Dexamethasone, Nitrogen Mustard Defibrase and Chinese medicine were not complete remission yet. These patients in remission period were applied Chlorambucil to and observed the prognosis and the drug side reaction.

32例接受正规中西医结合"四联"疗法（地塞米松、盐酸氮芥、降纤酶、本院中药制剂）后病情仍有反复的患者，在原治疗基础上于病情缓解期口服苯丁酸氮芥，临床观察病情转归情况和服药后的副作用。

For this group type 2 diabetes was considered to be in remission.

对这一组来说，2型糖尿病，可以认为是"治愈" in remission。

Results Analysis of the expression of proteins of JAK2 in leukemic blasts, there was no detectable constitutive expression of phosphorylated JAK2 in all the AML samples analyzed; Furthermore, we could detect a constitutive activation of STAT 3 by immunoprecipitation of the targeted protein in primary leukemic blasts from 3 of 11 AML patients without any cytokine treatment; Pretreatment clinical characteristics, and treatment regimens did not differ significantly between patients with and without constitutive STAT3 activity, there was not significant relation between the constitutive activation of STAT3 and the FAB subvariety and chromosome karyotype; However, the 3 patients with constitutive STAT3 activity seemed to have adverse treatment outcome, one did not show remission, the other two patients relapsed shortly after remission; Consistent with the above-mentioned result, leukemic blasts from the 3 samples with constitutive expression of STAT3 showed higher percentage of spontaneous apoptosis and S-phase cells.

在实验研究基础上，本研究进一步运用免疫沉淀和Western Blot印迹方法，检测AML患者原代细胞JAK2和STAT3活化情况，并分析了STAT3活化与AML患者预后有关指标改变的关系。结果我们的初步研究发现，11例AML患者中，有3例呈现STAT3组成型活化（STAT3阳性，下同），无一例呈JAK2组成型活化。上述3例STAT3组成型活化与FAB分型和染色体核型改变未见明显相关性；在此3例患者中，1例未取得缓解，另外2例虽然取得短暂缓解，但均在二个月内复发。上述3例STAT3阳性AML患者S期白血病细胞百分率数值较组高，而凋亡率数值较低。

AML is a clonal disease,but the clonality after remission is still contraversary,In order to analyse the clonality of haematopoiesis in AML before- and after remission,we studied the HUMARA gene polymorphism and the clonality of 30 previously untreated AML,15 AML in complete remission and 20 female cont...

急性髓系白血病是一种克隆性疾病，完全缓解后恢复正常多克隆性造血。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。