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In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis.

综合全部实验结果,本研究提示:夏季和低龄是托吡酯引起泌汗障碍的主要危险因素,而托吡酯剂量对泌汗(来源:A44B8787C论文网www.abclunwen.com)功能的影响较小;托吡酯可以抑制小鼠汗液的分泌,小鼠的年龄并不影响这种抑制作用,但托吡酯对小鼠体温无明显影响;托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗;托吡酯不影响汗腺形态及Na,K-ATP酶活性;汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关,而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

With the rapid development of related trades, the demand of markets for phthalic anhydride growths more rapidly.

随着相关行业的快速发展,市场对苯酐的需求量增长较快。

Hardness and temperature, current density, chromium content of sulfuric acid anhydride and are closely related.

铬层软度与温度、电流密度、铬酐及硫酸的含量都有紧密亲密的干系。

The second BE"find out the property that the related responsibility person combines an analytical problem, carry on animadversion and punish".

第二是"找到相关的责任人并分析问题的性质,进行批评和处罚"。

Only to serve a good awareness and growth potential of agriculture and animal husbandry industry and related industries customers.

只服务于有良好意识和成长潜力的农牧行业及相关行业客户。

I have constructed and screened a cDNA library of Xenopus oocytes with E-cadherin probe. One of the four cadherin-related mRNAs analyzed is possibly localized to the animal pole.

在本篇论文中,我们建立了蛙卵母细胞的cDNA library,并利用E-cadherin 探针从中选殖到几个cadherin-related基因,在已分析的四个基因中有一个基因在卵母细胞中有不均匀分布发生。

We are looking for someone to animate a logo for a game related website.

我们正在寻找一个能为动画的游戏相关网站的一个标志。

The system can be used to simulate the engineering mechanics field, structure behaviors and other related areas animatedly.

多媒体系统与数学物理模型一起所形成的仿真新体系,扩展了仿真系统的效能和应

The problem with animating cloth is directly related to its complex nature.

的问题,生动活泼的布,直接关系到其复杂性。

The natural elements of the aesthetics such as"mononoaware"are closely related to"animatism"and"vegetal aesthetics,"and the underlying cultural factors of such aesthetics can be attributed to Buddhist teaching, caducity of life and deism.

物哀"美学等自然审美的实质与"万物有灵观"及"植物美学观有关,其审美观的深层文化原因可视为佛教思维、无常观及自然神灵论的影响。

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推荐网络例句

The work of this paper is as follows: 1. Looking back the progressing history of the linear motor, introducing the features of the elevator driven by linear induction motor, radicating the topic of this paper "the digital frequency variable control of the elevator bi-side direct driven by linear induction motor". The research of this paper covers the conventional VVVF control, space vector based VVVF control, vector control and DTC.

本文主要开展了以下几个方面的工作: 1 回顾了直线电机发展历史,电机的驱动技术演变,特别是针对直线电机的驱动,简要介绍了直线感应电机驱动电梯的优点和不同结构类型,对传统的v/f控制,基于空间矢量法的v/f控制,矢量控制,和基于电压空间矢量的直接转矩控制进行了比较,确立了本课题的研究主题:直线感应电机双边直推式驱动电梯的全数字变频控制。

The article combines with the treatment of a superficial civil air defense work to introduce how the grouting method to improve the performance of the backfill soil.

文章从治理漂浮人防工事的角度提出了注浆技术在改善回填土性质方面的应用,并详细阐述了注浆技术的施工流程。

I knew nor shyness nor fear, my life was boisterous.

我不懂得羞怯和惧怕,我的