查询词典 regulation

Objective:The aim of the experiment is to search for the regulation that the hepatic stem cells abnormally differentiate into cancer cells. In the experiment,the variating regulation of PCNA,c-kit and c-myc in the formation and development of HCC will be interpreted with immunohistochemistry and RT-PCR. So,the initial mechanism that hepatic stem cells abnormally differentiate into cancer cells from the levels of cell,protein and gene will be clarified. The last,the inhibition to HCC with ulinastain will be studied,from which,a new way of clinical prevention and treatment for HCC will expect to be explored.

二、目的本实验旨在探讨以卵圆细胞为代表的肝干细胞在HCC发生、发展过程中在肝组织内分布规律，并通过免疫组化、RT-PCR等技术阐明PCNA、c-kit、c-myc在HCC发生、发展过程中的动态演变规律，从细胞、蛋白、基因三个水平初步研究卵圆细胞向癌细胞异常分化的机制，同时观察乌司他丁对HCC发生、发展的抑制作用，为肝癌的临床预防和治疗探索新的途径。

1、Cur inhibits K562 cells growth and induces cell apoptosis may be correlated with the down-regulation of p210~、inhibition of protein tyrosine phosphorylation and the signaling molecules such as p-Erk1/2、c-myc which are relevant with cell growth and apoptosis; 2、Cur synergizes STI571 to inhibit K562 cell growth and induce cell apoptosis may be correlated with the down-regulation of p210~、inhibition of protein tyrosine phosphorylation and the signaling molecules such as Hsp90、PKC which are relevant with cell growth and apoptosis; 3、Cur reverses the resistance of K562/G01 cells to STI571, and synergizes STI571 to inhibit K562/G01 cell growth and induce cell apoptosis; 4、Cur inhibits human originated CML CD34~+ cell growth、induces cell apoptosis, and enhances STI571 to down-regulate the expression of p210~, finally inhibit cell growth and induce cell apoptosis.

从以上实验结果我们得出如下结论： 1、Cur抑制K562细胞增殖、诱导细胞凋亡的作用可能与其下调p210~、蛋白酪氨酸磷酸化水平以及抑制下游p-Erk1/2、c-myc等信号分子有关； 2、Cur协同STI571抑制K562细胞增殖、诱导细胞凋亡的作用可能与其下调p210~、蛋白酪氨酸磷酸化水平以及抑制Hsp90和下游PKC等信号分子有关； 3、Cur可逆转K562/G01细胞对STI571的耐药性，并与STI571协同抑制K562/G01细胞增殖和诱导凋亡，其抑制K562/G01细胞增殖、诱导细胞凋亡的作用可能与其下调p210~、蛋白酪氨酸磷酸化水平以及抑制下游Procaspase-3和NF-κB等信号分子有关； 4、Cur可抑制来源于CML患者骨髓的CD34~+细胞的增殖并诱导其凋亡，还可协同STI571下调CML CD34~+细胞p210~表达，进而协同抑制细胞增殖、诱导细胞凋亡。

The machine is compacted in its structure. ADC motor is used for stretching, thus a synchronous speed regulation and a single speed regulation can be achieved to meet the different parameters.The spinnerets are produced by the most advanced way, so that the flatness and uniformity of the thread can ensured.

整机结构紧凑、牵伸采用直流电机同步调速和单独调速，以确定不同的参数、喷丝头采用最先进的加工手段，保证了圆丝的光洁度和均匀度，全套设备运行平稳，控制灵敏，操作方便，安全可靠。

Electrician Cheng checks and accept a standard: Switch of leakage of electricity is installed it is correct, normal to use; The installation of electric parts of an apparatus, equipment is secured should firm, level off; Experiment of electric equipment electrify, lamps and lanterns tries bright reach lamps and lanterns to control function good; The exterior of parts of an apparatus such as box of switch, electrical outlet, terminal is in good condition, insulation parts of an apparatus is flawless, installation is firm, smooth, installation means accords with a regulation; The switch of paratactic installation, electrical outlet the deviation of terminal box, the clearance of periphery of the face plate of box of dark outfit switch, electrical outlet, terminal, box accords with a regulation; Authority of function of weak cable system is complete, satisfy use requirement, implemental installation is firm, smooth.

电气工程验收标准：漏电开关安装正确、使用正常；电气器件、设备的安装固定应牢固、平整；电器通电试验、灯具试亮及灯具控制性能良好；开关、插座、终端盒等器件外观完好，绝缘器件无裂纹，安装牢固、平正，安装方式符合规定；并列安装的开关、插座终端盒的偏差，暗装开关、插座、终端盒的面板、盒周边的间隙符合规定；弱电系统功能权齐全，满足使用要求，器具安装牢固、平正。

The difference is that, in the initial stage of innovations of pension system, draconian quantity regulation were put on the investments of pension funds; but with the deepening of pension system, the investment regulation to pension funds rums gradually to more relaxed prudent man rules, in order to direct investment management process, not to control their outcome.

而我国的现状是养老金系统的改革才刚刚起步，社保基金和企业年金尝试性地进入资本市场才只有不到2年的时间，我国证券市场的历史才只有不到15年的时间。而养老基金进入资本市场是实现保值增值必须的途径。

The query type interview of the controller of secure to be assigned personal responsibility for of 6 3 vise general manager of passenger station of be put in charge of passenger transport company, passenger station job makes clear, their great majority cannot give a the Ministry of Communication relative to thoroughly answer " car passenger station administers a regulation " in 4 of safety administration of the regulation main content, and these controller are divided individual outside, have.

对客运企业分管客运站的3名副总经理、6名客运站分管安全工作的负责人的提问式访谈表明，他们大多数不能相对完整地回答出交通部《汽车客运站治理规定》中规定的安全治理的四条主要内容，而这些负责人除个别外，都有。。。

By the research on RUC PM, we can induce the general regulation of project management of a high school, and rise the regulation to the certain theories for a guiding to my university.

通过对中国人民大学项目管理的研究，归纳出高校项目管理的一般规律，在将规律上升到一定的理论，指导我校项目管理工作。

And ZNF397nf function as transcription repressors. The different transcriptional regulation activity of the nf isoforms and their interaction with the fu isoforms would contribute to the complexity of the transcription regulation. To further examine the biological function of interaction between different isoforms we also analyze the potential role of ZNF191 and ZNF434 on signaling pathway. We found that ZNF191fu can significantly enhance the HSE-luciferase activity, while ZNF434fu can enhance the AP1-luciferase activity, then we analyze whether the nf isoforms have impact on the fu isoforms.

而这些成员的nf剪接本与它们对应的fu剪接本的转录调控功能有所不同，其中ZNF191nf与ZNF434nf剪接本的转录调控活性相对它们的fu剪接本显著降低，呈现较弱的转录抑制作用，但ZNF447nf剪接本却呈现出显著的转录激活作用，同时ZNF397nf剪接本则表现出显著的转录抑制作用，ZNF396nf剪接本的转录调控作用与其fu剪接本相当。nf剪接本这种与fu剪接本不尽相同的转录调控活性以及能与fu剪接本互作的能力，大大增加了转录调控作用的复杂性，这使得通过少量的转录因子作用来实现众多基因时空表达的不同成为可能。

The massive research materials indicated that the HMG-CoA reductases is the first key enzyme of the regulation of the mevalonic acid way, which has some reference value to promote the research on the biosynthetic pathway and the regulation of ginsenoside.

大量研究资料表明HMG-CoA还原酶是甲羟戊酸途径的第一个限速关键酶，这对人参皂苷生物合成途径及其调控的深入研究具有一定的参考价值。

Concretely analyzingrural class stratification and legal regulation ,we can make out that under currentlegal regulation,agricultural laborer class almost becomes puniest body in ruralsociety except that in the early days of reform.

具体地对农村阶层分化与法律调整进行分析可以看出，在现有的法律调整之下，农业劳动者阶层除了改革初期获利较多外，几乎成为农村社会最为弱小的群体。

And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47：5 法老对约瑟说，你父亲和你弟兄们到你这里来了。

Additionally, the approximate flattening of surface strip using lines linking midpoints on perpendicular lines between geodesic curves and the unconditional extreme value method are discussed.

提出了用测地线方程、曲面上两点间短程线来计算膜结构曲面测地线的方法，同时，采用测地线间垂线的中点连线和用无约束极值法进行空间条状曲面近似展开的分析。