查询词典 regulated

Objective To explore the role of nuclear factor-κB in the signal conduction of protein kinase C regulated proliferation, apoptosis and expression o f Th2 cytokines - interleukin-4 (IL-4) and interleukin-5 (IL-5) of T lympho cytes in the bronchial alveolus lavage fluid.

目的探讨核因子-κB在蛋白激酶C对豚鼠哮喘模型T淋巴细胞功能调控的信号传导中的作用。

Results The activation of NF-κB, proliferation response, and expression of IL-4 and I L-5 mRNA and protein in T lymphocytes stimulated by PMA were significantly hig her than those of their blank control (P.01), while those indexes of T l ymphocytes stimulated by PMA and PDTC simultaneously were significantly lower th an those stimulated by PMA alone (P.01). The apoptotic index of T lympho cytes stimulated with PMA were significantly lower than that of their blank cont rol (P.01), and the apoptotic index of asthmatic guinea pig T lymphocytes stimulated with PMA and PDTC simultaneously were significantly higher than that stimulated by PMA alone (P.01). The significant positive correlations w ere found between the activation of NF-κB and the proliferation (r=0.64, P.001), and the expression of IL-4 and IL-5 mRNA and protein of T lymph ocytes, respectively (r=0.55-0.68, P.001). There was also signific ant negative correlation between the activation of NF-κB and apoptosis of T l ymphocytes (r=0.62, P.001). Conclusions NF-κB may participate in the signal conduction of PKC regulated proliferation, apoptosis and expression of IL-4 and IL-5 of T lymphocytes in asthma.

结果加入PMA培养的哮喘组T淋巴细胞NF-κB的活化、细胞增殖反应、IL-4和IL-5的mRNA和蛋白质的表达均显著高于其空白对照(P.01)，而同时加入PMA和PDTC培养的哮喘组T 淋巴细胞以上指标均显著低于只加入PMA培养的哮喘组T淋巴细胞(P.01)；加入PMA 培养的哮喘组T淋巴细胞的凋亡指数显著低于其空白对照(P.01)，而同时加入PMA 和PDTC培养的哮喘组T淋巴细胞凋亡指数显著高于只加入PMA培养的哮喘组T淋巴细胞(P 。01)。T淋巴细胞NF-κB的活化与增殖反应呈显著正相关(r=0.64，P.00 1)，与IL-4和IL-5的mRNA和蛋白质的表达也均呈显著正相关(r=0.55-0.68，P 。001)，而与凋亡指数呈显著负相关(r=-0.62，P.001)。

HIF-1α is an oxygen-regulated protein and is recognized as a positive factor to tumorigenesis. During nomoxia, HIF-1α is rapidly hydroxylated by prolyl hydroxylase then goes into 26S proteasome degradation pathway. During hypoxia, HIF-1α accumulates and dimerizes with HIF-1β to transactivate hypoxia-responsive gene expression.

中文摘要缺氧诱导性因子-1α(HIF-1α)为一种对於氧分压敏感的转录因子，在正常氧分压下HIF-1α很快就被prolyl hydroxylase氢氧化进入26S蛋白酶体降解，当细胞处理缺氧环境时HIF-1α会累积并与HIF-1β形成复合物进行转录活化的作用；HIF-1α所调控的基因包括影响能量供给、细胞生长、血管新生等，被认为在肿瘤发育过程扮演促进者的角色。

HIF-1α is an oxygen-regulated protein and is recognized as a positive factor to tumorigenesis. During nomoxia, HIF-1α is rapidly hydroxylated by prolyl hydroxylase then goes into 26S proteasome degradation pathway. During hypoxia, HIF-1α accumulates and dimerizes with HIF-1β to transactivate hypoxia-responsive gene expression.

缺氧诱导性因子-1α(HIF-1α)为一种对於氧分压敏感的转录因子，在正常氧分压下HIF-1α很快就被prolyl hydroxylase氢氧化进入26S蛋白酶体降解，当细胞处理缺氧环境时HIF-1α会累积并与HIF-1β形成复合物进行转录活化的作用；HIF-1α所调控的基因包括影响能量供给、细胞生长、血管新生等，被认为在肿瘤发育过程扮演促进者的角色。

She said: This is the only area of medicine where drug dosages are not regulated, and that's wrong.

她说：这是唯一一个药物未受管制出现的空区，是错误的做法。

In addition to promoter regions, transcription of most eukaryotic genes is regulated by other dna sequences called enhancers.

除了启动子区域外，大多数真核基因的转录还受到另一段被称为增强子的dna序列的调控。

AIM: To construct an immortalized rat astrocyte strain expressing enkephalin regulated by Doxycycline.

目的：构建受强力霉素诱导表达脑啡肽的大鼠星形胶质细胞株。

An IAST which secretes enkephalin under the control of Doxycycline has been established successfully, which provides a good basis for further research on regulated gene therapy for chronic pain.

成功构建了受四环素及其衍生物强力霉素定量调控表达脑啡肽的永生化IAST，为可调控基因治疗慢性疼痛的研究奠定了基础。

An IAST secretes enkephalin under the control of Doxycycline has been established successfully, which provides a good basis for further research on regulated gene therapy for chronic pain.

成功构建了受四环素及其衍生物强力霉素定量调控表达脑啡肽的永生化IAST，为可调控基因慢性疼痛的奠定了基础。

The inducibility multiple of the iast/tet on cell strain was 20.6. rt pcr and immunocytochemistry confirmed that enkephalin expression level was regulated by doxycycline in a dose dependent manner.

成功构建了受四环素及其衍生物强力霉素定量调控表达脑啡肽的永生化iast，为可调控基因治疗慢性疼痛的研究奠定了基础。

Plunder melds and run with this jewel!

掠夺melds和运行与此宝石！

My dream is to be a crazy growing tree and extend at the edge between the city and the forest.

此刻，也许正是在通往天国的路上，我体验着这白色的晕旋。