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The mechanism of PPS accelerating IEC-6 cells migration was also researched with gene-chip technique. The Altas Clontech Rat cDNA Chip which consisted of 1176 spots representing different functional categories such as heat shock/stress, cell cycle, transcription factors, hormones, metabolism, etc was used. Result showed in cell migration model of IEC-6 cell line, compared with control group, expression of 38 genes in total 1176 genes varied in cells treated by PPS, including 21 genes up-regulated and 17 genes down-regulated. Date analyze showed the mechanism of PPS accelerating IEC-6 cells migration mainly related with promoting the numbers and activity of cellular ion channel, especially 〓 channel.

从以上实验结果中我们可以得出以下结论：四君子汤总多糖具有促进IEC-6细胞增殖、迁移、粘附的作用；四君子汤总多糖无论是对IEC-6细胞增殖、或者迁移的作用均优于各单味药多糖，可能是各种单味药多糖综合作用的结果；多糖可能是四君子汤"益气健脾"药效的主要成分；小肠上皮细胞可能是四君子汤总多糖的作用靶点之一，提示临床采用四君子汤及"益气健脾"法治疗"脾虚证"的疗效机制可能与增强机体的整体免疫和肠道粘膜免疫功能有关。

Five of these genes were selected for logistic regression analysis, of which two were the most up-regulated (CDA and MGC20553) and three were the most down-regulated (BANK1, BCNP1, and MS4A1) in CRC patients.

通过logistic回归分析，我们选择了这些基因中的5个基因。在这5个基因中，其中2个基因（CDA 和 MGC20553）在CRC患者中会上调表达；另外三个基因（BANK1，BCNP1，以及MS4A1）在CRC患者中会下调表达。

The expression level of metabolitic enzyme (CYP1A1, CYP1B1) and its correlation with cell differentiation /apoptosis were studied as well. The influence of resveratrol in cell cycle was determined with FCM. Results 1 Resveratrol not only suppresses the growth of medulloblastoma cells in a dose and time related fashion but also induces cell differentiation and apoptosis. Resveratrol promotes differention of UW228-1,-2 cells to forward glia, UW228-3 and Med-3 cells to neuron. A treatment of resveratrol in the concentration of 100μM for 48hrs comit most of cells die of apoptosis. 2 Among the four cell lines Fas and Caspase-3 were constantly expessed, whereas FasL was absent irrespective to the drug treatment. 3 ICC, RT-PCR, Western-blot hybridization and EROD enzymatic activity assay demonstrated that expression of CYP1A1 is different after treatment with resveratrol in four cell lines, up-regulated in three UW228 cell lines in a dose dependent manner but down-regulated in Med-3 cells. Suppressive effect of resveratrol on CYP1B1 expression is the same among four medulloblatoma cell lines. 4 Cell cycle distribution of UW228-3 was greatly changed after treatment.

结果：1、白藜芦醇以时间和剂量依赖性方式抑制髓母细胞瘤细胞生长，同时促进细胞的分化和凋亡：白藜芦醇促使UW228-1、-2靶细胞向神经胶质细胞方向成熟分化，UW228-3、Med-3细胞向神经元细胞方向成熟分化，以100μM作用48小时效果显著；2、四个细胞系均有Fas和Caspase-3表达，但无Fas-L基因表达和蛋白活性产生，因此难以形成Fas相关性死亡通路；3、白藜芦醇处理前后CYP1A1基因的表达在各细胞系略有不同：UW228-1，-2，-3三个细胞系白藜芦醇以剂量相关性方式上调CYP1A1的表达，而Med-3细胞系，白藜芦醇却抑制CYP1A1的表达；四个细胞系在白藜芦醇处理后CYP1B1的表达均受到抑制；4、UW228-3细胞系经白藜芦醇作用后细胞周期有较大改变，表现在G0/G1期在整个细胞周期中所占的比例增加，而其它时期则相应减少。

The author considers that two problems are worth reflecting and studying:One is the regulating range;the other is that when legislators regulated the rights of software copyrighter that regulated in the eighth item of Computer Software Protection Byelaw,they did not consider the characteristics of computer software itself and concerning to protection period, it did not solved interest balance in copyrights protection of software.

二是我国《计算机软件保护条例》第八条规定了软件著作权人所享有的一系列权利，大都是因袭了著作权法对著作权保护的规定，并没有考虑到计算机软件本身的特性。另外从保护周期等方面考虑，软件著作权保护中并没有解决利益平衡问题。

Results: 63 genes were up-regulated and 64 genes were down-regulated in the 127 differential expression genes.

结果：共筛选出127条符合标准的差异表达基因，63条呈上调表达，64条呈下调表达。

Results: miR27a was identified as the most stable reference gene by geNorm and Normfinder software. Among the 52 microRNAs detected by real time PCR array, miR-33 and miR-19a were significantly down-regulated, whereas miR-130 were significantly up-regulated in the hippocampus of Ts65 Dn mice as compared with the euploid control mice. The expression of miR-802, which was the trisomy chromosome 16 derived microRNAs, was very low in hippocampus with no difference between the two groups.

结果：geNorm和Normfinder两种方法均选定miR-27a为最稳定的内参照基因，共检测了52种microRNAs，其中miR-33和miR-19a在Ts65Dn小鼠海马组织中表达显著下调，miR-130在Ts65Dn小鼠海马组织中表达显著上调，小鼠16号染色体三体区段包含的miR-802在Ts65Dn小鼠和对照二倍体小鼠海马组织中表达量均低，差异没有统计学意义。

Up-regulated proteins under salt stress include an ABC transporter permease, glycerol-3-phosphate permease, pyrimidine nucleotide transporter, formate dehydrogenase, and down-regulated proteins include succinate dehydrogenase iron-sulfur subunit, flavoprotein subunit, cytochrome b-556 subunit, and a hypothetical membrane protein similar to charperone DnaJ. Some of these changes were further verified by enzyme activity assay.

盐胁迫诱导上调表达的蛋白包括ABC型转运蛋白，3-磷酸甘油透性酶，嘧啶核苷转运蛋白和甲酸脱氢酶；下调表达的蛋白包括琥珀酸脱氢酶铁硫亚基、黄素蛋白亚基、细胞色素b556亚基，以及分子伴侣DnaJ的同源蛋白，酶活力测定结果表明胁迫条件下上述蛋白的活性变化与表达量变化相一致。

Article 16: Within the allotted time of the land's remise, the grantee should use the land according to the applications and the use conditions regulated in this contract. If the applications and use conditions regulated in this contract should be changed, the relevant formalities should be transacted according to the laws. An application to the granter for permission to sigh the change protocol of the remise contract of resign the remise contract, adjust the rent for remise of the land's use right and transact the registration of the change of land.

第十六条在出让期限内，受让人必须按照本合同规定的土地用途和土地使用条件利用土地，需要改变本合同规定的土地用途和土地使用条件的，必须依法办理有关批准手续，并向出让人申请，取得出让人同意，签订土地使用权出让合同变更协议或者重新签订土地使用权出让合同，相应调整土地使用权出让金，办理土地变更登记。

G/ml. After wt-p53 transfection and VCR treatment, the number of Bel-7402 cells was decreased; the cells were swollen severely with irregular projections; pyknosis, karyorrhexis and karyolysis were observed. After wt-p53 transfection, the expression of mdr1 and P-gp in Bel-7402 cells was down-regulated remarkably, and the expression of TopoⅡα was up-regulated.

形态学检查转染细胞，在VCR作用下细胞数明显减少，细胞散在不成片、细胞高度水肿、胞体不规则突起，可见核固缩、核裂解、核溶解。p53基因对Bel-7402细胞的mdr1/P-gp的表达有明显的抑制作用，对TopⅡα基因的表达有上调作用，对GSTπ、MRP基因表达没有影响。

On this basis, the author holds that the preceding procedure for notice before enforcement can be cancelled, the confirmation procedure for the start of enforcement should be set up, the reasonable and running ways to realize the enforcement of the prestation by act should be regulated, and the contents for the enforcement relief should be regulated, and the contents for the enforcement relief system should be completed. As a result, the civil enforcement system of China can be improved continuously

在此基础上，笔者认为，可以取消执行通知前置程序，设立执行开始确认程序，规定合理的、可操作的行为给付的强制实现途径，充实执行救济制度的内容，从而不断完善我国的民事强制执行制度。

I am accused of being overreligious," she said in her quiet, frank manner,"but that does not prevent me thinking the children very cruel who obstinately commit such suicide.""

客人们在卡罗利娜·埃凯家里，举止就文雅一些，因为卡罗利娜的母亲治家很严厉。

Designed by French fashion house Herm è s, this elegant uniform was manufactured in our home, Hong Kong, and was the first without a hat.

由著名品牌 Herm è s 设计，这件高贵的制服是香港本土制造，是我们第一套不配帽子的制服。