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The increases in calcium channels α2/δ1 subunit, GABA〓 receptors α5 subunit, sodium channels and nACh receptors in both DRG and spinal cord indicate their potential roles in the development of new target of analgesia drug.

本研究发现的一些在外周神经损伤后DRG和脊髓背角内都上调的分子，如钙通道α2／δ1亚基、GABA〓Rα5亚基、若干钠通道亚基和nACh R亚基，为寻找新的镇痛药物靶点提供了一定的线索。

Notch1 is expressed by stem cells resided in the cervical loop epithelium, and Notch signaling pathway play a central role in fate decision of those stem cells. Notch receptors and their ligands are involved in both patterning and cell fate determination during odontogenesis. Moreover, many cell factors, which are closely related with odontogenesis, could regulate expression of Notch receptors or their ligands.

既往研究显示：早在牙齿发育期，Notch1就表达于颈环星网状层的干细胞中，是其保持干细胞性质的重要机制；Notch-Delta信号还与成釉细胞、成牙本质细胞分化有关，被认为是牙齿发育细胞分化多样性的原因之一；另外，目前已明确与牙胚细胞分化有关的生长因子如TGFβ、FGF、BMPs等均可诱导Notch受、配体的表达。

These results show that overexpress the Tra2β1 protein may influence the propotion of the flip/flop of the AMPA receptors, and change the kinetic and ion selective of the receptors. So it can drive the development of the neural synapses.

此实验表明：过表达Tra2β1蛋白可能影响了神经细胞谷氨酸AMPA型受体flip/flop型剪接的比例，并且改变了AMPA受体的动力学和离子选择特性，从而加速了神经突触形成的发育进程。

The results showed the bacterial supernatant and periplasm containing NKAT2 scFv were able to bind the NKAT2 receptors expressed on cell surface,but NKAT4 scFv failed to bind to NKAT4 receptors.

结果显示，含NKAT2－scFv的细菌上清及胞质提取物均可识别到表达在细胞表面的NKAT2受体分子，但含NKAT4－scFv的细菌上清及胞质提取物均未成功

Key words:protein P53;Genes C-erbB-2;Receptors,Estrogen;Receptors,Progestational Hormones;breast neoplasms;Immunohistochemistry

目的：探讨乳腺癌中P53、C-erbB-2基因蛋白及雌激素受体、孕激素受体的表达及其临床病理意义。

Retinoic acid and its receptors play a very important role in the development of the embryo.RA signal transduction is mainly mediated through it\'s two kinds of receptors, retinoic acid receptor and retinoid X receptor, each kind of receptor has 3 isoforms, a, 6,?.

维甲酸(Retinonic acids，RAs)和其受体在胚胎的发育过程中起着很重要的作用，RA信号的传导主要通过它的两种受体即维甲酸受体和维甲酸类X受体，每种受体又有3种亚型，α，β，γ。

Retinoic acid and its receptors play a very important role in the development of the embryo.RA signal transduction is mainly mediated through its two kinds of receptors, retinoic acid receptor and retinoid X receptor, each kind of receptor has 3 isoforms, a, 6,?.

维甲酸(Retinonic acids，RAs)和其受体在胚胎的发育过程中起着很重要的作用，RA信号的传导主要通过它的两种受体即维甲酸受体和维甲酸类X受体，每种受体又有3种亚型，α，β，γ。

However, opioid receptors are not expressed naturally in great abundance, they are relatively labile and frequently difficult to solubilize as monomers. The availability of their cDNAs makes them good candidates for overexpression in heterologous cells, which offers hope for the purification of membrane receptors for biochemical and structural studies.

在生物体内，阿片受体的含量很低，分离纯化过程中受体蛋白不稳定、易形成多聚体。cDNAs的克隆成功使阿片受体的异源高效表达成为可能，为研究阿片受体蛋白的生化特性和结构特征创造了条件。

We tested whether inhibitory GABAergic synaptic transmission regulates Xenopus optic tectal cell dendritic arbor development in vivo by expressing a peptide corresponding to an intracellular loop ofthe gamma2 subunit of type A GABA receptors GABA(AR, which is required to anchor GABA receptors to the postsynaptic scaffold.

我们想证明如下设想：抑制性GABA能突触传递是否能调节早蟾视顶盖细胞的树突发育。因为GABA受体的gamma2亚基有一段细胞内的跨膜端序列，这段序列对锚定GABAA受体到突触后膜是必须的，所以我们的主要方法是设计了一段特异性的争对细胞内段的序列，这样就特异性的阻断了单个细胞GABA能的突触传递。

Methods: Eleven B-CLL patients were studied. Leukemic lymphocytes with (n=8) or without (n=3) P2z receptors were exposed in vitro to ATP, benzoylbenzoic-ATP, 2-methylthio-ATP(2MeSATP), adenosine-5′-［γ-thio］ triphosphate, and other nucleosides for 8h. Apoptosis was detected by electron microscopy, agarose gel electrophoresis, and quantitative TdT assay. Results:Apoptosis was detected only in leukemic lymphocytes with P2z receptors. By using the quantitative assay, ATP-inducing DNA strand breaks were found to occur specifically for BzATP, ATP and 2MeSATP, but not for ATP-γS and other nucleosides.

将表达P2z受体［P2z］与不含P2z受体［P2z］的两组CLL细胞分别同1.0mmol/L三磷酸腺苷体外培养8小时，以电镜、DNA凝胶电泳和定量DNA 3′端TdT法检测细胞凋亡；并对ATP、苯甲酰苯甲酸ATP、2-甲基硫ATP(2MeSATP)、γ-硫代ATP及其它核苷的诱导效应和氧化型ATP、1-［N，O-二(5-异喹啉碘酰基)N-甲基-L-酪氨酰］-4-苯哌嗪KN-62）的抑制效应做定量研究。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐