查询词典 receptor site

Retinoic acid and its receptors play a very important role in the development of the embryo.RA signal transduction is mainly mediated through its two kinds of receptors, retinoic acid receptor and retinoid X receptor, each kind of receptor has 3 isoforms, a, 6,?.

维甲酸(Retinonic acids，RAs)和其受体在胚胎的发育过程中起着很重要的作用，RA信号的传导主要通过它的两种受体即维甲酸受体和维甲酸类X受体，每种受体又有3种亚型，α，β，γ。

Although PRMT1 methylates nuclear orphan receptor HNF4,whether TR3,another orphan receptor,is methylated by PRMT1 and how the methyltransferase activity of PRMT1 is affected by nuclear receptor remain largely unknown.

虽然PRMT1可以甲基化核受体HNF4，但孤儿受体TR3能否发生甲基化以及PRMT1的甲基化酶活性是否被核受体调控等问题还不清楚。

The flexible atom receptor model also gives the pseudo receptor model, which indicates possible interactions between receptor and the ligand.

FLARM方法的计算结果还给出了虚拟的受体模型，该模型说明了抑制剂与受体之间可能的相互作用。

First, the significant of co-factor InsP6 and center water in the mechanism of auxins are explored by docking; second, the experiments that compared with the docking rusults of two situations involving fully rigid and selective flexible of active residue of the receptor TIR1 illuminate that selective flexibility docking by AutoDock4 reports more rational results, so that, AutoDock4 dockings are implemented with TIR1-Auxins; third, AutoDock4 docking by TIR1-Auxins-Aux/IAA illuminates that auxin as a molecular glue enhances the interaction between TIR1 receptor and Aux/IAA substrate by the weak interactions, such as hydrogen bond and hydrophobic interaction, furthermore, the weak interactions between receptor protein and ligands greatly influence on auxin activity of auxin ligands.

首先， 通过分子对接计算研究辅酶InsP6以及中心水分子在生长素反应中的重要作用；其次，比较受体大分子完全刚性以及活性残基部分柔性的两种情况下的分子对接结果，说明AutoDock4实现了受体分子活性残基的部分柔性而使对接结果更加合理，进而使用AutoDock4方法对TIR1-Auxins体系进行对接计算；最后，对TIR1-Auxins-Aux/IAA体系进行分子对接计算，结果表明，生长素配体分子作为&分子胶水&直接与受体大分子TIR1以及底物多肽Aux/IAA形成强的弱相互作用，如氢键作用、疏水相互作用，促进了受体TIR1与Aux/IAA底物之间的结合，进而说明氢键作用和疏水相互作用等弱相互作用对于生长素分子的活性具有很大的影响。

This inhibitory effect was increased by 4ɑ-PDD, a selective TRPV4 receptor agonist, and was reversed by ruthenium red, a nonselective TRPV4 receptor antagonist, suggesting that the inhibition is mediated via TRPV4 receptor.

4低渗透压对IATP的抑制作用可被TRPV4(transient receptor potential vanilloid 4)受体激动剂4ɑ-PDD(4ɑ-phorbol 12，13-didecanoate)增强，并可被TRPV4受体非特异性阻断剂钌红(ruthemium red， RR)阻断。

The calculated results show that H atom preoccupies the twofold bridge site of the subsurface on the intact W(100) surface at low coverage, and obtains the perpendicular vibration frequency of 156 meV. The H-atom adsorption on bridge site, top site and fivefold hollow site (the top site on the second W layer) were observed at high coverage.

计算结果表明，低覆盖度下， H原子优先吸附在W(100)面的内层吸附位二层桥位B'，获得156 meV的垂直振动频率，随着覆盖度的增加， H原子稳定吸附在表层的五重洞位、桥位及顶位。

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Phage display of recombinant human lymphotoxin mutation librariesand receptor affinity screeningContraction of conformable large molecule mutation library is pivotal for molecular evolution study in vitro. In order to extend the range of the screening region of amino acid in LT gene, several receptor binding sites of LT were mutated randomly by overlap PCR amplification with the random nucleotide primers, the R46, S106, L130 combined site-directed random mutation library and R46~A52, S106~F110, R46~A52 + S106~F110 region random mutation libraries of rhLT were constructed successfully.

二。重组人淋巴毒素噬菌体库的构建及受体亲和筛选构建适合的大容量生物大分子变异体文库是进行体外分子进化研究的关键，为了扩大LT基因序列中被筛选的氨基酸范围，我们采用含随机核苷酸序列的引物，通过Overlap PCR的方法对LT的受体结合区域进行多点随机突变，分别构建了rhLT R46+S106+L130三点随机突变组合文库和R46～A52、S106～F110、R46～A52+S106～F110区域随机突变体库。

Results Several amino acid substitutions located in antigenic sites or receptor binding sites were found more in the isolates than the current vaccine virus or the isolates from previous year. Amino acid substitution was found in 3, 140, 142, 144, 145, 158, 159, 189, 192, 193, 198, 204, 225, 226 and 227 positions in the isolates during 2003-2008, more amino acid substitutions took place in antigenic determinant A, B and receptor binding site.

结果 每个流行期分离的毒株都较当年的疫苗株或前一年的毒株出现了位于不同抗原决定簇或者受体结合位点的氨基酸替换。2003-2008年不同流行期分离株在3，140、142、144、145、158、159、189、192、193、198、204，225、226和227位点氨基酸发生了变化，多数的改变发生在抗原决定簇A、B及RBS。

According to the prediction results of secondary structure of receptor β chain, the general theory about relationship between cytokine and its receptor at binding site and blocking results of polyclonal antiserum against D1 (9～114 residure of β chain), the new three peptides, which comprised residures of 45～75, 56～75 and 66～75, were designed and synthesized.

依据对受体β链二级结构的预测、受体与细胞因子结合部位的结构理论以及抗受体β链D1(9～114)片段多克隆抗血清有阻断GM-CSF促进DMSO诱导HL60细胞增殖活性的结果，设计和固相合成了受体β链第45～75，56～75和66～75三个人工合成多肽片段。

"Bird Man's Diary, Butting on the Love Island", Changsha, China

2008年"鸟人日记，顶在爱情岛"，中国长沙

As long as they were in the service of a family of wizards, their magic would remain dormant.

只要他们一天为家庭服务，他们的法力就潜藏不动。