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Methods Male NIH rats were treated with water containing 0.1% lead acetatic trihydrate for establishing an experimental lead poisoning rats model. QQL health liquid was administrated to rats through every day. Thirty days later, rats were killed, then the concentration of lead in blood, liver and femur were determined.

取小鼠,饮水给予0.1%三水合乙酸铅水溶液建立小鼠预防性铅中毒模型,同时灌胃给予不同浓度的受试物,喂养30天后测定血、肝脏和股骨中的铅含量。

Intra-portal alopecia was observed in all rats which received 30 Gy and some rats which received 20 Gy. The abnormal neurological signs were not found in all the rats, but the tend of body weight increase was less pronounced in 1-3 months in the irradiated rats than those unirradiated.

所有存活大鼠无异常神经系统体征,30Gy剂量组全部和20Gy部分大鼠照射后射野内有脱毛,而且照射组大鼠在受照后1至3个月期间,体重的上升趋势低于未照射组大鼠,但无统计学差别。

After three weeks, animals were randomly divided into four groups:(1)diabetic rats received intensive insulin therapy for 20 days;(2)diabetic rats received unregular insulin therapy, which caused the abrupt fluctuation of glycemic level;(3)diabetic control rats; and (4)normal control rats.

中文摘要:目的观察胰岛素治疗对糖尿病大鼠视网膜血管内皮细胞生长因子(vascular endothelial growth factor, VEGF)和血管生成素-2(angiopoietin-2, Ang-2)表达的影响,探讨胰岛素在糖尿病视网膜病变发生发展中的作用。

Methods Eighteen Wistar rats were randomized into 3 groups, namely the CLP group (n=6) in which the rats were subjected to cecal ligation plus puncture to induce severe abdominal infection, L-Arg group (n=6) where the rats received 300 mg/kg peritoneal L-Arg injection following CLP establishment, and the control group (n=6) where the rats underwent ventrotomy only.

18只Wistar大鼠随机分为CLP组(n=6)、ARG组(n=6)和对照组(n=6),CLP组和ARG组均采用大鼠盲肠结扎加穿孔制作严重腹腔感染模型;ARG组术后于腹腔注射L-精氨酸(300 mg/kgd),CLP组术后注射等量生理盐水,对照组仅行剖腹术。

BACKGROUND:Ola rats is a kind of rats with genovariation, who displays Wallerian degeneration after peripheral neuroaxonal damage that is slower than that normal 6J rats, thereby additional damage factor may help fully understand the property of Ola rats.

背景:Ola鼠是一种基因变异鼠,其周围神经轴突损伤后华勒氏变性速度比正常的6J鼠缓慢,增加损伤因素可能有助于了解Ola鼠的特性。

The effects of stimulation with electro-acupuncture on the pain threshold, 5-HT in brain stem, the β-END in hypothalamus and hypophysis, the β-END and ACTH in the blood plasma as well as the function of the cellular immunity of the normal rats, the hypophysis extirpated rats and the PHA injected rats were observed in this experiment. In the meantime, the pain threshold of rats injected with cyclophosphamide was observed too.

本实验观察了电针对正常、摘除垂体以及PHA大鼠痛阈、脑干内5—HT、下丘脑、垂体内β—END和外周血浆中β—END、ACTH含量以及机体细胞免疫功能的影响;同时,还观察了电针对Cy大鼠痛阈的影响。

Myocardialβ3-AR density up-regulation obviously(-5.16±0.004 vs -5.13±0.011, P.05)in rats treated with dexamethasone compared with rats treated with saline. 6. Myocardialα1-AR density up-regulation obviously(-5.16±0.017 vs -5.14±0.003, P.01)in rats with CHF compared with normal rats, buffy particle increased in myocardium slice. Gray scale value grew down, and i.e.α1-AR density greatened.

地塞米松治疗的心衰大鼠与注射生理盐水的心衰大鼠相比,心肌的β3-AR明显上调(-5.16±0.004 vs -5.13±0.011, P.05)。6大鼠心衰时,心肌的α1-AR密度明显上调(-5.16±0.017 vs -5.14±0.003, P.01),免疫组化采集的图像显示,心衰大鼠的心肌切片棕黄色颗粒明显增多,灰度值变小,密度变大。

Methods Mousetraps were distributed for the investigation; direct immune fluorescence was applied to detect the virus carriage in rats, 3451 mousetraps were distributed and 886 rats were caught, the rats density was 25.67%; 50 caught rats carried EHFV virus (5.64%) It has been proved that there exists a natural cycle of EHFV virus in Kaifeng County; effective measures should be taken to control the epidemic situation of EHFV.

用布夹法开展鼠密度调查,用直接免疫荧光技术进行鼠肺带毒检查。结果共有效布放鼠夹3451夹次,捕获鼠886只,鼠密度为25.67%。带毒50只,鼠类带毒率为5.64%。捕获鼠种有大家鼠、小家鼠、黑线姬鼠、大仓鼠和小仓鼠。结论证实河南省开封县存在肾综合征出血热病毒的自然循环,应采取有效措施控制流行性出血热疫情。

This may be explained by follows: First, Decoction Shenkangling can regulate the homeostasis of NEI network and reduce the increased activity of NF-κB to restrain the action of inflammatory-sclerotic media; Second, it can redress the disequilibrium of the ratio of TXA2/PGI2 to reform the hypercoagulable state; Third, it can enhance albumin and reduce cholesterol and triglyceride; Fourth, it can amend the renal damage and protect the function of renal tubule and stroma to prevent the transformation from MCD to FSGS; Last, it can lessen urine protein in AN rats markedly and relieve the side effects of prednisone.4. NF-κB, TXA2 and PGI2, along with the renal pathomorphology and so on can all be the indexes of the diagnosis of Symptom of "Kidney Deficiency and Blood Stasis" and the application of Methods of "Benefiting the kidney and Promoting blood circulation" in TCM.5. The curative effects on AN rats by treatment of integrating Traditional Chinese Medicine with prednisone are much better than using prednisone only. And the curative effects on AN rats by treatment of matching Decoction Shenkangling, having the function of "Benefiting the kidney and Promoting blood circulation", with Prednisone are much better than using Prednisone only.6. When it referred to decreasing urine protein, cholesterol and triglyceride and increasing albumin, Decoction Zhibodihuang excesses Decoction Taohongsiwu. However, when it referred to regulating the disequilibrium of TXA2/PGI2 and meliorating renal lesion, Decoction Taohongsiwu exceeds Decoction Zhibodihuang.7. The curative effects on AN rats by treatment of matching Methods of "Benefiting the kidney and Promoting blood circulation" with Prednisone overmatches using Prednisone matching Method of "Benefiting the kidney" or Method of " Promoting blood circulation" only.

益肾活血中药肾康灵能显著改善AN鼠的肾虚血瘀证的临床表现和实验指标,这可能与中药肾康灵能调理AN鼠机体的NEI网络功能稳态,降低异常升高的NF-κB活性,抑制免疫炎症/硬化介质环节,纠正失衡的TXA2/PGI2,改善AN鼠血液高凝状态,提高AN鼠的血清Alb,降低Ch和TG,减轻AN鼠的肾脏组织病理学变化,保护肾小管-间质功能,阻止MCD向FSGS转化;显著减轻AN鼠的尿蛋白水平以及减轻激素副作用有关。4、NF-κB、 TXB2和6-keto-PGF1α以及肾脏病理形态学改变等,都可作为中医肾虚血瘀证诊断和益肾活血法应用的客观指标。5、中西医结合干预AN鼠疗效优于单纯激素治疗;强的松配合益肾活血中药肾康灵组的综合疗效显著优于单纯强的松组。6、知柏地黄汤组在降低尿蛋白、提高血清Alb、降低Ch和TG疗效上优于桃红四物汤组;桃红四物汤组在纠正失衡的TXA2/PGI2和减轻肾脏病理损害方面优于知柏地黄汤组。7、激素配合益肾活血法干预AN鼠在一定程度上优于激素配合益肾法或活血法。

Results When compared with those of young rats, the total volume of white matter and the total length of myelinated fibers in the white matter of aged rats were decreased by 24.1% and 41%, respectively. In the white matter of aged rats, the volume density of myelinated fibers, the volume density of myelin sheathes and the mean diameter of myelinated fibers were increased by 30%, 23.9% and 31%, respectively, when compared with those of young rats.

结果 老年组大鼠大脑白质总体积,有髓神经纤维总长度分别下降了24.1%和41%;老年组大鼠有髓神经纤维体积密度、髓鞘体积密度和纤维直径分别增加了30%、23.9%和31%,具有统计学意义。

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