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Methods: On the basis of middle cerebral artery occlusion model in rats, free radicals were detected in hyperglycemic rats and normoglycemics.

建立大鼠左大脑中动脉梗死(Middle Cerebral Artery Occlusion,MCAO)模型,在证实高血糖可加重局灶性脑缺血损伤的基础上,检测正常和高血糖脑缺血后不同时间的自由基水平。

Methods: Hyperthyroid rats were induced by euthyrox given orally everyday for there weeks. Then the effect of combing hyperthyreosis formula being taken orally with Jiakangping ointment application on model rats was observed.

用左甲状腺素钠灌服造成大鼠甲亢模型,观察甲亢方内服与甲亢平膏外贴相结合对模型大鼠胸腺及脾脏指数改变的影响。

There was the significant difference in wall thickness and cavity area of left ventricular between the hypertrophied rats and sham-operated rats.

左室壁平均厚度和左室腔面积与假手术组比较有显著差异(P.05)。

MethodsUnder the conditions of constant temperature, constant humidity, auto-light and electromagnetic shielding, we gave experimental rats suanzaoren decoction at different doses and adopted chronicity electrode embedment technology to trace the EEG of hypodermal layer of freerunning rats , which rececived electric stimulation.

方法在恒温、恒湿、自动光控及电磁屏蔽条件下,给予实验动物不同剂量酸枣仁汤,采用慢性电极埋植技术描记电刺激所致失眠大鼠自由活动情况下的皮层脑电图。

Methods: The experimental type Ⅱ diabetic rats were induced by injection of strepiozotocin (STZ, 30mg/kg ) and fed with high fat and high glucose fond. The rats were divided into three groups: a normal conrmal control group, a diabetes group and a treated group. The treated group were hypodermically injected insulin 3U/d at interfemus for 4 months, white DC and NC group were vehicle groups that were treated with the same close saline, By using SABC method, thee express ion of collagen type Ⅰ and Ⅲ in SAN was detected.

高糖高脂饮食加小剂量链脲佐菌素腹腔注射(STZ,30mg/kg)制备Ⅱ型糖尿病大鼠模型,并随机分为正常对照组、糖尿病组和胰岛素治疗组(每只3U/d股内侧皮下注射),对照组和糖尿病组注射等剂量的生理盐水每天1次,持续4个月;窦房结组织行SABC法免疫组织化学显色,检测窦房结组织中的Ⅰ型和Ⅲ胶原的表达及变化。

The model of rat liver fibrosis was induced with compound factors of 40%CCl4-olive oil liquor injection hypodermically(2 time per week,six weeks),high fatty and low protein foods.Meanwhile the rats were given equivalent dosage of correspondent drug(1 time per day,six weeks).At the end of six weeks.All rats were executed and left liver tissue and serum.

用40%CCl4橄榄油溶液和高脂低蛋白饮食复制肝纤维化大鼠模型造模,同时予等效剂量健脾软肝方及拆方灌胃,并以鳖甲软肝片为对照,每天一次,6周末处死,留取大鼠血清、肝组织。

In the morning,rats in the model and the drug groups were ingested drink spirits,naming "Erguotou"(56°)(0.5ml/100 per day); In the afternoon, drugs were givenamong drug groups respectively, model group was given saline (1ml/100g per day).Meanwhile, The Model and the drug groups were given innutritious diet(40% flour+20% soybean meal+20%hypo-flour+20% botan-flour+a few soybean oil, salt),besides, those rats were prohibited to eat any food except water from 20:00 everynight to the next morning before gavage, the normal group was given saline and anormal diet.

肝纤维化模型组及药物组,上午:予56°白酒&二锅头&灌胃(每日1次,每次0.5ml/100体质量);下午:药物组予相应药物,模型组予生理盐水灌胃(每日1次,每次1ml/100体质量),且每晚八点后禁食至第二天上午空腹灌胃后再予饲料;正常对照组予等量的生理盐水做对照。

The results showed:(1) MP polymerase chain reaction test showed positive results in the bronchoalveolar lavage fluid from all of the MP-infected rats (infectious group, n=4), while they were all negative in BALF from the control group (n=4,P<0.05) and from those rats both infected with MP and, at the same time, treated with erythromycin (treating group n=4,P<0.05). Bacterial cultures of the bronchial and lung tissue were negative in all three groups. Using transmission electron microscope the widened interalveolar septa with increased amount of collagen were found in the infectious group, while there were no obvious abnormalities in the other two groups.

结果显示:(1)感染组动物(n=4)支气管肺泡灌洗液肺炎支原体-PCR检测均为阳性,而对照组(n=4)和感染加红霉素治疗组动物(n=4)均为阴性(P<0.05);三组动物的支气管和肺组织常规细菌培养结果均为阴性;感染组动物透射电镜检查见肺泡间隔增宽,其中有较多胶原纤维堆积,其余两组则未见明显异常。

Methods The antipyretic activity of SMPS was observed in rats with high temperature induced by dried yeast and 2,4-dinitrophenol; biliary duct cannula bile at 0.5,1,1.5,2,2.5 h after intraduodenal administration in rats was collected and counted to observe the effect of SMPS on biliary secretion;the weight of cholecyst in mice was counted to observe the effect of SMPS on the cholecyst of mice;the acute toxicity test of SMPS was done with mice.

采用干酵母、2,4二硝基苯酚致大鼠发热的模型观察玉米须多糖的解热作用;采用胆管引流法分别收集并计量给药后0.5,1,1.5,2 ,2.5 h的胆汁的方法观察SMPS对肝脏分泌胆汁的影响;采用测定小鼠胆囊重量的方法观察SMPS对胆囊的影响;对SMPS进行了小鼠急性毒性实验。

MethodsThe antipyretic activity of SMPS was observed in rats with high temperature induced by dried yeast and 2,4-dinitrophenol; biliary duct cannula bile at 0.5,1,1.5,2,2.5 h after intraduodenal administration in rats was collected and counted to observe the effect of SMPS on biliary secretion;the weight of cholecyst in mice was counted to observe the effect of SMPS on the cholecyst of mice;the acute toxicity test of SMPS was done with mice.

目的研究玉米须多糖的清热利胆作用及急性毒性。方法采用干酵母、2,4二硝基苯酚致大鼠发热的模型观察玉米须多糖的解热作用;采用胆管引流法分别收集并计量给药后0.5,1,1.5,2 ,2.5 h的胆汁的方法观察SMPS对肝脏分泌胆汁的影响;采用测定小鼠胆囊重量的方法观察SMPS对胆囊的影响;对SMPS进行了小鼠急性毒性实验。

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