查询词典 rats

Methods Duplicated the model of rats with pneumococcus pneumonia and divided the rats into young control group, young model group, aged control group and aged model group.

复制肺炎双球菌肺炎模型，分为青年对照组和模型组，老龄对照组和模型组。

Results:It was found that both of the hind ankle joints were swollen after CFA injection and the antibody production response to the challenge of sheep red blood cells in plaque-forming cell was significantly enhanced in AA rats. However, IgG production of splenocytes induced by pokeweed and the serum level of rheumatoid factor were not altered compared with control rats.

结果：AA大鼠致敏侧及对侧后肢踝关节均发生明显炎性肿胀，其脾细胞对SRBC诱导的抗体生成反应明显增强，但其脾细胞对PWM诱导的IgG的产生及血清类风湿因子水平与对照组相比并无升高。

Recently, it is proved that SP is also involved in pain modulation, acupuncture analgesia and immunoin- hibition. However, the role of CGRP in them is unclear Therefore, the dy- namic changes of CGRP-, SP-like immunoreactivity and expression ofα- CGRP,β-CGRP mRNAs in dorsal root ganglion and spinal cord in the arthritic rats were observed by using immunohistochemistry and in situ hybridization techniques combined with behavioral tests, respectively. Subsequently, the effects of this peoptide on the develoment of polyarthritis were investigated by intrthecal injections of CGRP and its antagonist in the rats. In addtion, GAL is a novel neuropeptide which coexists with CGRP and SP, but it may play a different role in the primary sensory system. Thus, we also observed the changes of GAL and GAL mRNA in DRG neurons and the spinal cord. The results were as follows

为此本文拟在大鼠佐剂性关节炎模型上，结合行为学测定、用免疫组织化学、原位核酸分子杂交技术观察脊髓背角及DRG中CGRP、SP、α-CGRP mRNA、β-CGRPmRNA的动态变化及电针的影响，此外，用鞘内和外周注射CGRP的工具药探讨了CGRP在佐剂性关节炎发生发展中的可能作用；甘丙肽（Galanin，GAL）也是新近发现的一个神经肽，并与CGRP和SP共存于DRG及初级传入末梢中，在神经损伤模型中脊髓CGRP、SP减少，GAL则明显增加，显示GAL与CGRP和SP的作用可能不同，因此在佐剂性关节炎模型上也同时观察了GAL和GAL mRNA的变化，实验结果如下

Results After many times oral administration of Jiangtangning capsules(40～600mg/kg),the blood glucose of hyperglycemic mice,rats and rabbits induced by adrenaline,glucose,streptozotocin and alloxan was decreased obviously,and had significant dose-effect relationship,the symptoms of polydipsa,polyphagia and polyuria were improved for alloxan-induced hyperglycemic mice and rats,meanwhile the release of insulin in alloxan-induced hyperglycemic mice serum was promoted,but having no apparent influence on the normal blood glucose of mice.

结果 在40～600mg/kg剂量下，多次灌服降糖宁胶囊对肾上腺素、葡萄糖、链脲佐菌素和四氧嘧啶引起的小鼠和大鼠以及家兔高血糖均有明显的降低作用，且有明显的量效关系，还可明显改善四氧嘧啶性高血糖小鼠和大鼠多饮、多食、多尿等三多症状，并可促进四氧嘧啶性高血糖小鼠血清中胰岛素的释放。但对小鼠正常血糖却无明显影响。

In order to investigate the effect of IFN-γon the expression of TNF-αin the hypothala- mus-pituitary-ovary axisof RU486-induced aborted SD rats, RU486 was used to establish the abortion model, then the aborted rats were administrated with different doses of IFN-γintraperitoneal injection, the method of immunohistochemical ultrasensitive SP was us- ed to study the variation of positive TNF-αcells in hypothalamus, pituitary, ovary and uterus in normal pregnant group A, aborted model group B and three different doses of IFN-γgroup C,D,E. The main goal of this research was to study whether the low dose of IFN-γcould have a protective function to pregnancy and the mechanism of its function so as to provide morph- ologic basis for the scientific using of IFN-γin the process of animal abortion control.

为探讨IFN-γ对流产大鼠下丘脑-垂体-卵巢轴(hypothalamus-pituitary- ovary-axis，HPOA )TNF-α表达的影响，本试验用米非司酮(RU486)建立SD大鼠流产模型，通过腹腔注射不同剂量IFN-γ，采用超敏感免疫组织化学SP法(链霉素抗生物素—过氧化物酶法)，观察了孕13天(d13)SD大鼠正常妊娠A组、流产模型B组、不同剂量IFN-γC、D、E组下丘脑、垂体、卵巢、子宫TNF-α的表达变化，探讨低剂量IFN-γ对妊娠是否有保护作用及其作用机制，期望能为在妊娠过程中如何科学应用IFN-γ防止动物流产提供形态学依据。

Using Gαq/11 polyclonal antibody as prole and immunoblot analysis, we measured Gαq/11 contents in left ventricle of rats. There was a significant decrease in Gαq/11 content of CA rats compared with values of control animals after 3 days of operation (P＜0.01). Gαq/11 contents were not modified in left ventricle after 10 and 30 days of stenosis.

以兔抗鼠Gαq/11多克隆抗体为探针，用免疫印迹方法测定了大鼠左心室组织中Gαq/11蛋白的相对含量，结果发现术后3天CA组大鼠左室中Gαq/11含量较SO组明显降低(P＜0.01)，术后10天和30天二组大鼠心肌中Gαq/11含量无差异(P＞0.05)。

The punctiform necrosis in the liver were found in two rats for high dose group. The white pulp cells in spleen were rarefactively distributed in four rats for high dose group.

病理学检查显示，高剂量组2只大鼠肝细胞可见点状坏死，4只大鼠脾脏白髓细胞疏松分布，各只雄性大鼠睾丸生精小管管腔直径增大，各层生精上皮细胞数目增多。

Alzheimer′s disease animal models were made by damaging bilateral nucleus basalis of Meynert of elderly rats (20-22 month) with quinolinic acid(150 nmol in 2 μL for each NBM, given d 3 after administration of test drugs). Activity of choline acetyltransferase was measured by radiochemistry assay. One time training passive avoidance step-down and water-maze spatial localization task were used to observe effects of ginsenoside of stem and leaf in combination with choline on learning and memory of AD model rats.

应用喹啉酸（每侧150 nmol，2 μL，给受试药后d 3注射）损毁老年大鼠双侧Meynert基底核制备阿尔茨海默病动物模型，放射化学法测定胆碱乙酰基转移酶活性，一次性训练被动回避跳台实验和水迷宫空间分辨能力测试，观察人参茎叶皂甙和胆碱合用对AD模型大鼠学习记忆的影响。

Methods Twenty rats were randomly divided into two groups,10 rats in each group.

方法将20只大鼠随机分为2组，每组10只。

The effect of meteorological factors on the rats density could be evaluated by RSM model. This model was superior to linear regression model. The effect of meteorological factors on rats density was resulted from multiple factors and their interaction.

响应面分析法能够较好地应用于气象因子对鼠密度的影响，建立的响应面模型优于多元线性回归，气象因素对鼠密度的影响是多因素及交互作用的结果。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。