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RESULTSdiabetic rats showed typical symptoms involving elevated serum glucose and weight loss (2)The rats in DM+VaD group reacted slower and made more error numbers in Y-maze than the rats in VaD group did, with a prolonged total reacting time in a whole day.(3)More neurons with serious damages, such as edema, ischemia or pyknosis could be found in DM+VaD group than in VaD group. More disarrangement of cone neurons, obvious glia proliferation, and more neuron apoptosis were found in CA area of hippocampus. CONCLUSIONS (1)2-VO in STZ-induced diabetic rats succeeded in establishing VaD animal models.(2) The cognitive dysfunction induced by VaD rats had been deteriorated by diabetes mellitus.(3)Morphology evidences proved that diabetes mellitus aggravated brain damages induced by VaD.PART II Effect of diabetes mellitus on the cholinergic nervous systemin CA1 area of hippocampus of VaDOBJECTIVE To estimate the role of cholinergic nervous system in hippocampus during the process of cognitive dysfunction aggravated by diabetes mellitus in DM+VaD group. METHODS Observe the changes of ChAT protein by immunohistochemistry stain. Chose three rats randomly from each group at each pointat two week, four week, and eight week, then sepa

经腹腔注射链脲佐菌素诱导慢性实验性糖尿病，1周后永久性结扎双侧颈总动脉(2-VO)制作VaD模型记录术后2周、4周和8周各组大鼠的体重及血糖；应用Y-迷宫检测空间定向学第二军医大学博士论文中…丈摘…要1ia；一色恤~﹁染澎糕行HE染色观察组织病理学孪叱；胶质细胞原纤维酸性蛋白protellZ，Cf冰尸标记观察星形胶质细舱的激活情况、橄声软公点娜育票票众糯黑橄居端粗默孺篇筑价井袱第二部分糖尿病对血管性痴呆大鼠海马c心区胆碱能神经系统的影响探讨海马CAI区胆碱能神经系统在糖尿病加重确D一大鼠认知障碍中所实验动物及分组同第一部分，应用免疫组织化学染色方法现察海马CAI{介狱牛第晕军l袭拔常博粗{论义

Rats with CHF were divided randomly into two groups, one group was injected dexamethasone(1mg /kg) intramuscularly at the first and forth day respectively,the other group was injected equi-volume saline likewise, and observing the changes of symptoms of rats with CHF; measuring rats hemodynamics index including blood pressure, heart rate and left ventricular end-diastolic pressure 4 days later. Part 2: To measure every group rats myocardialα1、β1、β2、β3-AR density by immunohistochemical method ,and to understand the AR density changes .Taking the first part rats'myocardium tissues for testing myocardialα1、β1、β2、β3-AR density and 5 normal rats for normo-contrast group and taking gray scale of slice as AR density. Part 3: The study enrolled 35 patients with DCHF. Patients were included if they had orthopnea and refractory edema due to acute DCHF that was severe and had taken more 1 week hospitalization and intravenous therapy in addition to diuretics.

观察心衰大鼠的症状，4天后对两组大鼠进行血流动力学检测，检测指标包括血压、心率和左室舒张末压；第二部分：取第一部分实验动物大鼠的心肌组织，并取5只正常大鼠的心肌组织作为正常对照，用免疫组化法检测大鼠心衰前后及糖皮质激素治疗前后大鼠心肌组织肾上腺素能受体α1、β1、β2、β3受体的变化，取镜下切片的灰度值反应受体的密度；第三部分：研究对象为临床难治性心衰病人35例，病人的选择标准包括由于急性失代偿的心力衰竭出现的端坐呼吸，难治性水肿，患者病情严重，住院超过1周，包括利尿剂之外药物的静脉治疗。

Compared focal mild hypothermia group rats with normothermia group rats, the former's water content and AQP4 of 3h ICH group rats' cephalophyma periphery showed no visibly changed, 6h ICH group rats and 24h ICH group rats visibly decreased, 72h ICH group rats obviously decreased.

亚低温治疗组血肿周围脑组织含水量和AQP4与常温组相比，脑出血3h组之间脑组织含水量及AQP4表达没有明显差别，亚低温降温组脑出血后6h、24h、72h组脑组织含水量明显降低，AQP4在脑水肿区周围表达明显减少，尤其是在72h，可观察到脑组织含水量及AQP4表达显著降低。

METHODS: Sixty healthy Sprague-Dawley rats were randomly divided into 3 groups: 6 rats in normal control group, 6 rats in EGb treating normal IOP group, and the other 48 rats were established chronic high IOP models of rats by cauterizing two episcleral veins. Then 30 rats satisfying experimental level were selected and randomly divided into five groups: 6 rats in physiological brine treating group, and the other 24 rats were divided into four experimental groups according to the dose of EGb: group A, EGb 50mg/; group B, EGb 100mg/; group C, EGb 150mg/; and group D EGb 200mg/. After the treating time of 1 month, the rats were sacrificed on schedule. Flat preparation of whole retinaes was stained distinctively and neuron counting in retinal ganglion cell layer from both eyes of each rat were performed to evaluate neuron situation.

取健康SD大鼠60只，正常对照组和正常银杏叶治疗组各6只，其余48只采用烧烙法，烙闭大鼠左眼2条浅层巩膜静脉，制作大鼠持续性高眼压模型，从中选出眼压稳定在实验要求水平的大鼠30只，随机分为生理盐水组，治疗A组（每日EGb 50mg/kg）、治疗B 组（每日EGb 100mg/kg）、治疗C 组（每日EGb 150mg/kg）、治疗D 组（每日EGb 200mg/kg），治疗时间为1mo，处死大鼠后做视网膜全层铺片，对RGCL神经元做特异性染色后行神经元计数分析来评估神经元的情况。

METHODS: Sixty healthy Sprague-Dawley rats were randomly divided into 3 groups: 6 rats in normal control group, 6 rats in EGb treating normal IOP group, and the other 48 rats were established chronic high IOP models of rats by cauterizing two episcleral veins. The n 30 rats satisfying experimental level were selected and randomly divided into five groups: 6 rats in physiological brine treating group, and the other 24 rats were divided into four experimental groups according to the dose of EGb: group A, EGb 50mg/; group B, EGb 100mg/; group C, EGb 150mg/; and group D EGb 200mg/. After the treating time of 1 month, the rats were sacrificed on schedule. Flat preparation of whole retinaes was stained distinctively and neuron counting in retinal ganglion cell layer from both eyes of each rat were performed to evaluate neuron situation.

取健康SD大鼠60只，正常对照组和正常银杏叶治疗组各6只，其余48只采用烧烙法，烙闭大鼠左眼2条浅层巩膜静脉，制作大鼠持续性高眼压模型，从中选出眼压稳定在实验要求水平的大鼠30只，随机分为生理盐水组，治疗A组（每日EGb 50mg/kg）、治疗B 组（每日EGb 100mg/kg）、治疗C 组（每日EGb 150mg/kg）、治疗D 组（每日EGb 200mg/kg），治疗时间为1mo，处死大鼠后做视网膜全层铺片，对RGCL神经元做特异性染色后行神经元计数分析来评估神经元的情况。

METHODS: Sixty healthy Sprague-Dawley rats were randomly divided into 3 groups: 6 rats in normal control group, 6 rats in EGb treating normal IOP group, and the other 48 rats were established chronic high IOP models of rats by cauterizing two episcleral veins. n 30 rats satisfying experimental level were selected and randomly divided into five groups: 6 rats in physiological brine treating group, and the other 24 rats were divided into four experimental groups according to the dose of EGb: group A, EGb 50mg/; group B, EGb 100mg/; group C, EGb 150mg/; and group D EGb 200mg/. After the treating time of 1 month, the rats were sacrificed on schedule. Flat preparation of whole retinaes was stained distinctively and neuron counting in retinal ganglion cell layer from both eyes of each rat were performed to evaluate neuron situation.

取健康SD大鼠60只，正常对照组和正常银杏叶组各6只，其余48只采用烧烙法，烙闭大鼠左眼2条浅层巩膜静脉，制作大鼠持续性高眼压模型，从中选出眼压稳定在实验要求水平的大鼠30只，随机分为生理盐水组，治疗A组（每日EGb 50mg/kg）、治疗B 组（每日EGb 100mg/kg）、治疗C 组（每日EGb 150mg/kg）、治疗D 组（每日EGb 200mg/kg），治疗时间为1mo，处死大鼠后做视网膜全层铺片，对RGCL神经元做特异性染色后行神经元计数来评估神经元的情况。

Supplement of pyruvate can increase serum LPL levels remarkably(p.05)and decrease serum HL level but no significant statistical difference in rats and swimming rats, decrease serum T4 levels during resting obviously(p.05)in rats and reduce serum T4 levels to certain extent in swimming rats. It indicated that pyruvate supplement could regulate lipometabolism in rats and swimming rats by means of the effect on enzyme and hormone levels.

丙酮酸补充还可明显降低大鼠血糖水平(P.05)，一定程度地升高其血清FFA水平；明显降低大鼠血清TC水平和游泳大鼠血清TG水平(p.05)，使大鼠和游泳大鼠血清HDL-C含量呈一定的升高趋势，并明显降低了游泳大鼠血清LDL-C水平(P.05)，这表明丙酮酸具有持久、稳定的降血脂作用，配合运动补充，作用效果可能会更明显；4。

The effect of F 1C on joint swelling and the immune respones of AA rats were evaluated by lymphocytotic reaction, flow cytometry, and ELISA. Results F 1C by ig administration to AA rats decreased the primary joint swelling of AA rats, stronger than TW and weaker than CsA, promoted the decreased splenocyte proliferation induced by Con A, and inhibited the augmented thymocyte proliferation induced by Con A in AA rats. The evaluation in vitro showed the F 1C inhibited the augmented thymocyte proliferation from AA rats and promoted the deficient IgG produced by splenocyte from AA rats.

结果 ig给予F1C(30mg／kg)对AA大鼠原发性足肿胀具有明显的治疗作用，该作用较TW强，较CsA弱；F-1C对AA大鼠低下的脾细胞增殖反应具有改善作用；对亢进的胸腺细胞增殖反应具有抑制作用。F-1C体外对AA大鼠低下的脾细胞产生IgG水平具有明显的促进作用，并能抑制亢进的胸腺细胞增殖反应。

Had rarely or never used protective;(11) MiceGrayAuto had realized the automatic processing of video data from the sexual preference observation system of rats, and MiceGrayManu had accomplished the analysis of images of sexual behaviors of rats;(12) Peripheral given of high dose androgen to female rats before its brain sexual differentiation had caused masculinization and defemininization in female rats, therefore led to homosexuality, and based on the results, we had established the female rat homosexual model;(13) Peripheral given of estrogen to male rats before its brain sexual differentiation had little effects on the sexual preference and sexual behavior of adult rats;(14) Peripheral given of estrogen antagonist to male rats before its brain sexual differentiation had markedly reduced masculine sexual behavior and interfered male sexual preference, but had no effect on feminine sexual behavior, and based on such results, we had established the male rat homosexual model, however the model have to be improved for better sensitivity;(15) The volume of sexually dimorphism nucleus of the preoptic area of the high dose androgen-treated female rats was significantly greater, while on the other hand the volume of AVPV of which was significantly lesser, than the female rat control.

并且有17.79％的男性同性恋者在1年内与异性保持着性关系。但在与异性阴道性交时，绝大多数（92.51％）偶然或不使用安全套；(11)MiceGrayAuto软件实现了大鼠性偏爱视频数据自动处理功能，MiceGrayManu软件实验了大鼠性行为图象分析功能；(12)大脑性分化前高剂量的雄激素有促雌鼠雄性化和去雌性化的作用，并表现为同性性倾向，建立了雌鼠同性恋模型；(13)在雄鼠大脑性分化前外周给予雌激素对成年后的性偏爱和性行为未产生明显影响；(14)在雄鼠大脑性分化前外周给予雌激素拮抗剂明显削弱雄性性行为，阻碍了雄性性偏爱，但雌性行为无明显变化，雄鼠的同性恋模型还有待进一步调整和改进：(15)高剂量雄激素处理的雌鼠SDN-POA体积明显大于对照雌鼠组，而AVPV体积明显小于对照雌鼠组。

The coeve to the plasma study of monoamine neurotransmitter in normal person and schozophreniac on four mian solar term in four seasons; tostudy the amount and the component of middle molecule substances in plasma on four main solar term in four seasons in nor- mal person and schizophreniac; to estabisht the experimental animal model of sehijorhrenia and the improve the measurement index; to study monoamine neurotransmitter value of brain in normal rats and experimental schizophrenia rats on four main soler terms; to study the amount and component of MMS in plasma of normal rats and experi- mental schizophrenia rats on four main solar terms, and to make The morphological study of the brain tissue in experimental schizophre- nix rats and normal rats.

健康人、精神分裂症患者一年四季血浆单胺类神经递质含量的研究。2。健康人、精神分裂症患者一年四季血浆中分子总量及组分的研究。3。精神分裂症动物模型的建立及评分标准的改进。4。正常大鼠、精神分裂症模型大鼠一年四季脑组织单胺类神经递质含量的研究。5。正常大鼠、精神分裂症模型大鼠一年四季血浆中分子总量及组分的研究。6。精神分裂症模型大鼠、正常大鼠脑组织形态学研究。

Neither the killing of Mr Zarqawi nor any breakthrough on the political front will stop the insurgency and the fratricidal murders in their tracks.

在对危险的南部地区访问时，他斥责什叶派民兵领导人对中央集权的挑衅行为。

In fact,I've got him on the satellite mobile right now.

实际上 我们已接通卫星可视电话了