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Results In the medium and high dose F0 groups, it was observed that the atrophy and incrassation of seminiferous tubule, decrease of spermatogenesis, hyperplasia of interstitial tissue, especially in high dose groups spermatozoon abnormality and nucleolus concentration in the rats testis after DU ingestion for 14 months. The changes became more severe with the prolongation of DU ingestion. Such changes occurred in filial rats (F1) after DC ingestion for 5 months. In the medium and high dose F0 groups, it was observed that a little atrophy of kidney glomerulus, hyperplasia of interstitial tissue after DC ingestion for 14 months, and kidney glomerulus fibrosis happened after DC ingestion for 20 months, such changes occurred in filial rats (F1) after DC ingestion for 5 months In the medium and high dose F0 groups, splenic germinal center and periarterial lymphatic sheaths were hyperplasia , companies with lymphopoiesis after DC ingestion for 7 months, splenic white pulp became more small and sparse after DC ingestion for 20 months.

结果 F0代的中、高剂量组大鼠摄入贫铀14个月后可见雄性的精曲小管萎缩,管壁增厚呈空虚网状,生精细胞层次减少,间质细胞增生,但仍见有精子生成;高剂量组可见到精子呈异型性改变,细胞核浓缩深染,且随着摄入时间延长改变愈趋明显;F1代大鼠摄入贫铀5个月后就有上述改变且更为严重。F0代中、高剂量组大鼠摄入贫铀14个月后肾小球轻度萎缩,间质增生明显,20个月时肾小球萎缩纤维化;F1代大鼠摄入贫铀5个月后就有上述改变。F0代中、高剂量组摄入贫铀7个月时脾脏生发中心和淋巴鞘增生,淋巴母细胞增生活跃,20个月时脾小体减少,生发中心稀疏;F1代大鼠摄入贫铀早期和晚期有类似改变。F0和F1代高剂量组摄入贫铀早期肝脏有炎症细胞浸润,晚期骨髓有核细胞减少,脂肪细胞增加。

Methods Lung squamous cell carcinoma was induced with methylcholanthrene in iodized oil in Wistar rats. Ninty-one rats were used for this experiment, and the rats were sacrificed on the 20th, 40th, 50th, 60th, 70th and 80th days respectively.

方法经肺叶支气管内灌注甲基胆蒽碘油溶液对91只Wistar大鼠诱癌,分别于灌注后第20、40、50、60、70、80天分批处死动物并采取血清。

Myocardial ischemic model was made and hypotension in the dogs was induced with ligating left front descending limb coronary artery method, and secondary hypertension by narrowing nephridium artery of rats, Shenfu injection was administered with 5, 10mL·kg-1 to the above dogs and rats separately to investigate the influence of it on the hemodynamic indexes of myocardial ischemic dogs and blood pressure of rats.

结扎犬左冠状动脉前降支造成心肌缺血及低血压;缩窄大鼠腹主动脉造成血管阻力增加而形成继发性高血压;分别给予参附注射液5 ,10mL·kg-1,观察其对犬血流动力学和对动物正常血压或高血压的影响。

Methods1. Compared with adult female rats, aged female rats without oestrum were chosen by using RIA technology and sexual hormone was changed remarkably. Theses aged rats were divided into three groups(GNK group, HRT group and control group). Treated them respectively with GNK, nilestriol and distilled water 3 months.

通过用阴道脱落细胞涂片检测发情周期的改变,放免法测定血清性激素的水平,与正常青年雌性大鼠比较,选择阴道脱落细胞无发情期改变,血清性激素水平有增龄性改变并且差异有显著性的老年雌性大鼠作为研究对象,分别用中药复方更年康和尼尔雌醇灌胃3个月,观察中药复方更年康对老年雌鼠的治疗作用。2。

Methods 40 SD rats aged 10~12 months were divided into 4 groups. Bilateral oophorectomy w as performed in the experiment rats. Three months later, the rats were given BM210955 in dosage of 0.5mg·kg-1.d-1 by gavage for 3 months.

取10~12月龄SD大鼠40只,分为4组,实验组大鼠作双侧卵巢切除3个月后,再给予BM210955 0.5mg·kg-1.d-1,用药3个月。

Methods Making 20% bleaching water solution by using 10% CP with Carbopol or PVP as carriers and 10% Opalescence. Experiment rats were perfused the bleaching solution by 5ml/kg via oral route continually for seven days, control rats were perfused distilled water according to equal standard, then combine clinical signs, food utilization rate and pathology to evaluate the short term systemic toxicity of the lab rats.

将以卡波姆或聚乙烯吡咯烷酮为增稠载体的10%CP和10%Opalescence漂白凝胶制备成20%的水溶液,实验组白鼠按5ml/kg经口途径给服,对照组按同等标准给服等量蒸馏水,持续7天,通过临床体征、食物利用率、体重相对增长率以及病理表现来评价受试材料的短期全身毒性。

Objective:To explore the effect of Opuntia dillenii Haw against oxidation in rats. Methods:Thirty healthy Wistar's rats on two months were randomized into 3 groups with 10 rats in each.

2个月龄Wistar健康大鼠30只,雌雄各半,按体重随机分为3组:空白对照组,仙人掌低剂量组,仙人掌高剂量组。

Methods: The seventy-two 10-month female Sprague-daweley rats were randomly divided into treatment part (sham, model, BBC treatment high, BBC treatment low dose and QIANGGU CAPSULE control groups) and preventing part (sham, model, BBC preventing high and BBC preventing low dose grougs).All rats were taken ovariotomy except rats in sham group.

将72只SD大鼠随机分为治疗(假手术组、模型组、中药治疗高剂量组、中药治疗低剂量组、阳性对照组)和预防(假手术组、模型组、中药预防低剂量组、中药预防高剂量组)两部分,除假手术组外,全部大鼠行双侧卵巢切除术。

METHODS Eighty-four healthy mature Wistar rats were divided into two periods, in which 36 rats for the first period and 48 rats second period, and each period included control group, rhubarb group and phenolphthalein group.

健康成年Wistar大鼠84只,分2期,第1期36只,第2期48只,均分为对照组饲以普通饲料、大黄组饲料中添加有大黄粉和酚酞组饲料中添加酚酞。

And then the arthritis gradually alleviated and recovered on day 28. In addition, GAL-LI greatly rised in DRG, but decreased in laminae Ⅰ,Ⅱ of the dorsal horn following the development of polyarthritis (n=3 or 5). In the arthritic rats (n=5 or 6), EA at points could alleviate hyperalgesia and ongo- ing pain, and prevent the rats suffering from polyarthritis, meanwhile the in- crease of CGRP-, SP-and GAL-LI was reduced.Ⅱ. Expression of α-CGRP,β-CGRP and GAL mRNAs in DRG neurons of the arthritic rats and acupuncture effects

实验还观察到在动物形成变态反应性关节炎时,DRG中GAL-LI明显增加,但在背角却明显减少(n=3);3、经电针治疗(佐剂后20天内隔天电针双环跳穴一次,持续15min)关节炎动物炎症反应减轻,同时脊髓背角和DRG中CGRP-和SP-LI的增强反应减弱,GAL-LI在DRG中的增加和在背角中减少的反应也均有所减弱,并使关节炎动物以及脊髓背角和DRG中上述递质的变化恢复加快。

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