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Twenty-four hours after the last oral administration, the blood were obtained and used for testing adrenocorticotrophic hormone, cyclic adenosine monophosphate, cyclic guanosine monophosphate, glucose, cholesterol, alanine aminotransferase, urea nitrogen. Results Before taking medicine, model rats' cAMP/cGMP and ACTH were lower than normal rats', and they showed a trend of rise with adding dose. Before taking medicine, model rats' GLU was lower than normal rats'. With adding dose, model rats' GLU increased, however, normal rats' GLU reduced. When taken medium dose white prepared lateral root of aconite, model rats' CHO was higher than normal rats'. Taking medicine made both groups ALT rise, but normal rats' went up more quickly than model rats'. Model rats' BUN was higher than normal rats', and taking low dose or little dose medicine could lead to incline of reduction.

结果 给药前模型组环磷酸腺苷/环磷酸鸟苷和促肾上腺皮质激素低于正常组，随着给药剂量的增加，两者有升高的趋势；给药前模型组血糖低于正常组，随着给药剂量的增加，模型组GLU有升高的趋势，而正常组有下降的趋势；中剂量给药时模型组总胆固醇显著高于正常组；随着给药剂量的增加，2组丙氨酸氨基转移酶均有升高的趋势，且正常组ALT升高的幅度更大；给药前模型组尿素氮高于正常组，低、小剂量给药有降低模型组BUN的趋势。

Through the source code audit such as RATS software can find the flaw information of level of partial source code, but after all the majority that software of source code audit searchs spills over for the existence buffer such as Strcpymemcpy the C function that involuntary discharge of urine has, the measure that adopts audit source code so will undertake flaw is dug is coefficient of a possibility very small leak digs a technology, and the flaw that although also can find a few software,checks in the light of the black box of software, but possibility coefficient also is met lesser, a few undertakes flaw is dug idea that are in abroad already slowly promotion writes black box to check code for oneself, the module of a certain function that is aimed at system or software next undertakes modular flaw digs a technology.

通过RATS等源代码审计软件可以找到部分源代码级别的漏洞信息，但是究竟源代码审计软件寻找的多数为strcpymemcpy等存在缓冲区溢出遗患的C函数，所以通过审计源代码的办法来进行漏洞挖掘是一个可能性系数很小的漏洞挖掘技术，而针对软件的黑盒子测试虽然也能找到一些软件的漏洞，但可能性系数也会较小，在国外的一些进行漏洞挖掘的办法已经慢慢的提升为自己写黑盒子测试代码，然后针对系统或软件的某个功能模块进行模块化的漏洞挖掘技术。

Results: For CRF rats which made by fed with feedingstuff contains 0.75% of adenine for 4 weeks, the weight of model control group rats were lighter than that of Yi Shen Granule groups rats. The water wastage of Yi Shen Granule groups rats were less than that of model control group rats. Compared urine volume, the ejectable quantity of Na, K, Cl and proteinuria in 12 hours , the data of Yi Shen Granule groups rats were less than that of model control rats. The specific gravity of Yi Shen Granule groups rats was higher than that of model control rats. The numerical value of RBC, HGB, HCT, MCV, MCH in model control group was lower than that in Yi Shen Granule groups. The content of BUN and Cre in serum of model control groups rats were higher than that of Yi Shen Granule groups. The results of excretion test of phenolsulfonphthalein showed that the RPF of Yi Shen Granule groups rats was larger than that of model control group rats.

结果： 益肾颗粒可以使0.75%腺嘌呤饲喂法致大鼠慢性肾衰模型动物体重增长加快；给药后观察，给药组动物饮水量较少，12小时尿量、12小时钠、氯、尿蛋白排泄总量均显著低于模型组动物，尿液比重值较大；模型组动物的RBC、HGB、HCT、MCV、MCH等指标的数值较给药组动物的数值小；给药组动物血清中BUN和Cre的含量较低；给药组动物酚红排泄率均高于模型组动物；给药30天，处死各组动物，尸解观察，模型对照组动物肾脏呈灰白色，各给药组动物肾脏表面均出现不同程度的红、白相兼的颗粒状纹理，各组动物肾脏均肿大，切面可见不同程度的腺嘌呤结晶沉积。

The comparisons of biochemistry between OP and OR rats The differences between OP and OR rats included not only body weight, but lipids metabolism and insulin sensitivity as well, characterized with insulin resistance, increasing in serum free fatty acids and ketone body, and hepatic TC and TG in OP rats. However, no significant differences were observed in serum TG, TC, LDL, HDL and fasting glucose between OP and OR rats.⑶Comparisons of metabolites in serum, urine and liver tissue between OP and OR rats①There were significant differences in amino acids concentration between OP and OR rats,especially in liver tissue, such as high concentrations in ketogenic and glucogenic amino acids in OP rats, suggesting differences in amino acids metabolism;② The different metabolites between OP and OR rats included increasing of various saturated fatty acids and decreasing of polyunsaturated fatty acids in OP rats;③The urinary metabolites analysis indicated that different structure or metabolism of gut microflora might exist between the two phenotypes, which probably influenced the regulation of body weight gain;④The end-products of catecholamines in urine and intermediates of krebs cycle in serum in OP rats were all up-regulated, suggesting that the activity of sympatheic nervous system and energy metabolism was higher in OP rats than OR rats.

胰岛素耐受实验和胰岛素敏感指数表明OP动物的胰岛素敏感性较OR动物下降，而OP大鼠血清中游离脂肪酸、酮体、肝脏总胆固醇和甘油三酯水平显著升高；但是，OP与OR大鼠血清中总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白和空腹血糖等的水平并无显著性差异；⑶肥胖易感与肥胖抵抗大鼠血清、尿液和肝脏组织提取物中代谢物的比较研究表明：①OP与OR大鼠的血清、尿液和肝组织提取物中多种氨基酸的含量存在显著差异，并以肝组织中的差异氨基酸数量为最多，包括各种生酮和生糖氨基酸水平在OP组的升高，说明氨基酸代谢的差异是两种体重表型大鼠之间存在的重要差异特征之一；②OP与OR动物肝脏和血清差异代谢物中包含多种饱和长链脂肪酸的升高如十四烷酸、十六烷酸、硬脂酸等和多不饱和脂肪酸的下降如亚油酸和花生四烯酸，说明两种体重表型动物的肝脏脂肪酸代谢存在明显差异；③长期高脂饮食喂养后，动物的尿液代谢物分析表明OP与OR动物体内的肠道菌群结构存在差异，这些菌群上的差别可能在动物体重增长的调节上产生影响；④与OR动物相比，OP动物尿液代谢物中儿茶酚胺类递质的代谢终产物如高香草酸、扁桃酸和4-羟基苯乙酸明显升高。

Purpose: To explore and make big rats model of sterility caused by chronic salpingitis, observe the effect of Tongluozhuyunfang on the pathology and morphallaxis of oviduct, interleukin IL-2、IL-6 in serum and oviduct, and trace the rats pregnant rate for exploring its curative mechanism.

中文题名通络助孕方对炎性不孕大鼠输卵管作用的实验研究副题名外文题名 Experimental study on mechanisms of Tongluozhuyunfang treated rats salpingitis sterility 论文作者赵广兴导师马宝璋袁家麟教授学科专业中医妇科学研究领域\研究方向学位级别博士学位授予单位黑龙江中医药大学学位授予日期2002 论文页码总数63页关键词不孕症通络助孕方输卵管炎馆藏号BSLW /2003 /R271.1 /4 目的：探索制作慢性炎症所致不孕大鼠模型，探讨中药通络助孕方对慢性炎性不孕大鼠输卵管病理形态学、细胞因子IL-2、IL-6和受孕率的影响及其疗效机理。

There is no evidence that low doses (1 mg/kg) of alpha-methylscopolamine alter central effects of pilocarpine, but higher doses i.e., 10 mg/kg in mice and 20 mg/kg in rats, s.c.

没有证据表明，低剂量的(1 mg/kg)α-甲基东良菪碱改变匹罗卡品的中枢效应，但是高剂量i.e。， 10 mg/kg in mice and 20 mg/kg in rats， s.c。

Objective to evaluate the functional recovery of acute spinal cord injuried rats treated with exogenous wnt-3a signal protein administration and to explore its mechanism.methods moderate spinal cord contusion injury was made in 40 adult sprague dawley rats at t10.twenty rats served as contusion controls(group 1).twenty rats were treated with wnt-3a for three days after injury (group 2).the functional recovery of the rats was observed through basso,beattie,bresnahan open field locomotor score.rats were killed at 14 or 28 days after injury,then spinal cords were removed for histopathological examinations,and the expression of the bromodeoxyuridine plus neural cell markers was stained with immunohistochemical method.results rats of two groups receiving a contusive injury recovered substantial function within 1 week.by 28 days,rats in groups 2 scored 7.0 points better on the bbb scores than rats in group 1 group 2=16.94,after 28 days vs.

目的 研究外源性wnt-3a信号蛋白对脊髓损伤的修复作用，并探讨其作用机制。方法取40只成年雌性sd大鼠在t10节段制备适度脊髓挫伤模型。随机从中取20只为损伤对照组(group 1)，另外20只为损伤治疗组(group 2)。脊髓损伤3天后用wnt-3a蛋白治疗。这些大鼠的功能恢复通过basso、beattie、bresnahan开放视野运动评分来观察。这些大鼠分批在损伤后14天或28天被处死，取出损伤节段脊髓用来组织病理学检查，同时用5-溴脱氧尿嘧啶核苷和神经细胞标记物进行免疫组化染色。结果两组大鼠在伤后一周运动功能有明显的恢复。不过，到损伤后28天，我们观察发现，损伤治疗组中的大鼠bbb评分比损伤对照组中的评分高出7.0分左右(group 2∶16.94±1.18，group 1∶9.89±1.29；p.05)，光镜和电镜检查发现wnt-3a蛋白对髓鞘形成和轴突再生有一定的修复效果。

METHODS: Sixty healthy Sprague-Dawley rats were randomly divided into 3 groups: 6 rats in normal control group, 6 rats in EGb treating normal IOP group, and the other 48 rats were established chronic high IOP models of rats by cauterizing two episcleral veins. The n 30 rats satisfying experimental level were selected and randomly divided into five groups: 6 rats in physiological brine treating group, and the other 24 rats were divided into four experimental groups according to the dose of EGb: group A, EGb 50mg/; group B, EGb 100mg/; group C, EGb 150mg/; and group D EGb 200mg/. After the treating time of 1 month, the rats were sacrificed on schedule.

取健康SD大鼠60只，正常对照组和正常银杏叶治疗组各6只，其余48只采用烧烙法，烙闭大鼠左眼2条浅层巩膜静脉，制作大鼠持续性高眼压模型，从中选出眼压稳定在实验要求水平的大鼠30只，随机分为生理盐水组，治疗A组（每日EGb 50mg/kg）、治疗B 组（每日EGb 100mg/kg）、治疗C 组（每日EGb 150mg/kg）、治疗D 组（每日EGb 200mg/kg），治疗时间为1mo，处死大鼠后做视网膜全层铺片，对RGCL神经元做特异性染色后行神经元计数分析来评估神经元的情况。

In this study, streptozotocin was administrated to induce SD rats type I DM. After the induction completed, 100mg/kg、400mg/kg Hibiscus sabdariffa extracts or 100mg/kg、200mg/kg Hibiscus sabdariffa polyphenols were fed by oral tube to observe the effects on DM rats.

本研究利用streptozotocin 65mg/kg，以腹腔注射来诱发Sprague-Dawley rats糖尿病的发生后，每日依体重给予洛神花水层萃取物100mg/kg、400mg/kg及洛神花多酚 100mg/kg、200mg/kg。

And Leon has annoyed the group of fans you do not want to annoy - the Dagenham Dogs, a bunch of hooligans who follow a group called the Sewer Rats, who have just been given a right royal slagging by young Leon.

里昂惹恼了别人不敢得罪的一群粉丝——达格南道格斯，这是一群追随一个叫Sewer Rats组织的小流氓，他们被年轻的里昂打得正着。

Neither the killing of Mr Zarqawi nor any breakthrough on the political front will stop the insurgency and the fratricidal murders in their tracks.

在对危险的南部地区访问时，他斥责什叶派民兵领导人对中央集权的挑衅行为。

In fact,I've got him on the satellite mobile right now.

实际上 我们已接通卫星可视电话了