查询词典 rat

Objective It was reported that rALR (rat augmenter of liver regeneration) distribute in most of tissue and organ of rat, no-tissue specility; mRNA expression of rALR was identified variedly in different tissue, strongest in testis. But nowadays there was not some study on ALR in rat testis. Here to confirm the expression and localization of ALR in infancy,adult and old rat testis,comparing the change of ALR expression degree before per 70 PH and after per 70 PH. In order to evaluate expression principle of ALR in rat testis and know if ALR has tight connection with spermatogenesis and development of testis, to explore the relation between ALR and reproduction, to discover the possible expression character and functional methods of ALR.

目的：文献报道rALR分布于各组织器官，无组织特异性，但其mRNA在各组织的表达强度有差异，在睾丸组织表达最强，目前对大鼠睾丸ALR表达尚无深入的研究；本实验研究不同年龄段大鼠睾丸组织中肝再生增强因子的表达水平、表达部位、以及表达的方式，进而探讨睾丸ALR与睾丸发育、精子生成以及生殖活动的关系；同时探究睾丸组织ALR表达是否参与了肝脏的再生过程中，进一步了解睾丸ALR表达的特性及作用方式。

The study of mechanism of its anti-inflammationThis experiment shows that NTL can inhibit the edema of hind paw induced by fresh egg white in adrenalectomized rat, reduce the weight of thymus in rat, increase the content of hepatic glycogen ,but decrease eosinophil of mice through experimentalstudy of effect of NTL on edema of hind paw induced by fresh eggwhite in adrenalectomized rat, weight of thymus in rat, content ofhepatic glycogen and eosinophil of mice. The results indicate that NTL has the analogous function to cortin.

抗炎机理研究通过虎斑游蛇对去肾上腺大鼠蛋清性足跖肿胀、对大鼠胸腺重量和对小鼠肝糖原含量及对小鼠嗜酸性粒细胞数量影响的实验研究，表明虎斑游蛇能够抑制去肾上腺大鼠蛋清性足跖肿胀，使小鼠胸腺的重量减轻，增加小鼠肝糖原的含量而减少嗜酸性粒细胞的数量，提示虎斑游蛇具有肾上腺皮质激素样作用。

On the basis, further isolated-living condition and moderate unpredictable stress are applied successively to set up PSD rat model . The neurological functional recovery of stroke rat is assessed by Longa 5 grades and horizontal bar test.Sucrose solution consumption test, open-field test and passive avoid test are used to estimate the change of interest, the level of spontaneous motor activities and investigative behavior of PSD rat model.Fluorophotometry is applied to detect the monoamine neurotransmitters(NE,5-HT and DA) of the double frontal-parietal cortexes and brain stem. Investigating the action of YuLeShu on the neurological functional recovery of stroke rat.

运用Longa5法和水平木棒法评定卒中大鼠神经功能恢复；运用糖水实验、敞箱实验、被动躲避实验评定PSD大鼠的兴趣感变化和自发活动、探究行为等抑郁行为学改变；采用荧光分光度法测定双侧额顶皮层及脑干的单胺递质：去甲肾上腺素(Norepinephrine，NE)、5-羟色胺(5-Hydroxytryptamine，5-HT)、多巴胺(Dopamine，DA)含量。

The present invention selects and uses hereditary hypertension rat and rat with normal blood pressure to make hybridization, and the rat whose blood pressure is normal and arterial pressure susceptivity reflection sensitivity is less than 0.3 ms/mm Hg can be screened out from filial generation, bred and propagated, and repeatedly bred and propagated, after above 12 generations so as to obtain the invented pure rat with stable hereditary property and spontaneous arterial pressure susceptivity reflection functional defect.

本发明涉及医学实验动物模型技术领域，是培育用于心血管疾病防治研究的一种自发性动脉压力感受性反射功能缺陷的纯种大鼠的方法。本发明选用遗传性高血压大鼠和正常血压大鼠杂交，从子代中筛选出血压正常、动脉压力感受性反射敏感性低于0.3ms/mmHg的大鼠培育繁殖，并反复按此标准在其下一代中筛选、繁殖，经12代以上便得到遗传性稳定的自发性动脉压力感受性反射功能缺陷纯种大鼠。

To choose SD rat as experiment obiect, which was divided in to 5 groups: normal control group, model group, methylaminopterin-treat group, tripterygiumglycosides-treat group, and GuiZhiShaoYaoZhiMuTang-treat group, establishing immunityinflammation rat model., through measuring rat voix pedis intumesce degree, the content ofIL-6, TNF-A in peripheral blood, and rats weight as well as organ index, we can observe theeffect of GuiZhiShaoYaoZhiMuTang for treating adjuvant-induced arthritis rat and theby-effect.

以SD大鼠为实验对象，将大鼠随机分为5组：正常对照组、模型对照组、甲氨喋吟治疗组、雷公藤多甙治疗组、桂枝芍药知母汤治疗组。建立免疫性炎症关节炎大鼠模型。通过测量大鼠足跖肿胀程度，外周血IL-6、TNF-α及大鼠的体重和脏器指数，来观察桂枝芍药知母汤对佐剂性关节炎大鼠的治疗作用和副作用。

ResultsComparing with gonadectomy Shenyangxu model group, Wenyangyishen Capsules can improve upset excitability of male rat of gonadectomy penis Home News for Overseas Service Department , shorten erection incubation period; The rat increasing gonadectomy male sex attaches weight modulus of sexual organ; Can urge the hypophysis , adrenal gland weight modulus to increase by, weight adjusting the thymus gland , spleen; Elevate rat serum testosterone、Cortisol contents obviously; Be caused by messenger Cortisol the various Shenyangxu model small rat symptom gets laxation disappear even.

结果 与去势肾阳虚模型组比较，温阳益肾胶囊能提高去势雄性大鼠阴茎对外部刺激的兴奋性，缩短勃起潜伏期；增加去势雄性大鼠附性器官的重量系数；能促使垂体、肾上腺重量系数增加，调节胸腺、脾脏的重量；明显升高大鼠血清睾酮、皮质醇含量；使氢化可的松所致阳虚小鼠各项症状得到缓解甚至消失。结论温阳益肾胶囊具有益肾壮阳的功效。

To detect effects on apoptosis of cortex neuron in DHCA rats, the rat model of occluding bilateral common carotid artery in the deep hypothermic (21C) rats had been established, and flow cytometry, TUNEL, electron microscope, immunohistochemistry and RT-PCR had been studied.: part I: To establish a new rat model of cerebral ischemia/protect during DHCA: 20 SD rats were used in the experiment, little animal respirator was to assist anesthetized rat's respiration after tracheal cannula, artery press through artery spile in femoral artery, electrocardiograph, temperature, blood saturation of O2 (SaO2) and arterial blood gases were monitored during the whole experiment, blood flow of bilateral common carotid artery of rat were occluded about 60 minute when its temperature was reduced to 21 C by ice, then normal temperature was resumed.

本研究采用大鼠深低温颈总动脉阻断模型，应用流式细胞仪、电镜、原位缺口末端标记法、免疫组化法和RT-PCR技术分别检测深低温脑缺血对皮层神经细胞调亡的影响方法：第一部分深低温停循环脑保护大鼠模型的建立：SD大鼠20只，麻醉后气管插管辅助呼吸，用冰块将大鼠的体温降至(21±1)℃，阻断双侧颈总动脉，记录体温、心率、血压、血氧饱和度和血气分析，60分钟后恢复颈总动脉血流，用Longa等的5级评分标准评定4小时和24小时后大鼠神经系统损伤情况。

IL-1βmRNA expression in the developmental brain in Wistar rat: IL-1β mRNA in hippocampus, cerebral cortex and subcortex was detected by postnatal day 1 and gradually increased with development, reached a peak at postnatal day 21, and then gradually decreased to lower level at adult; In P77PMC rat, IL-1β mRNA expression was similar to Wistar rat before postnatal day 14, then gradually increased and surpassed Wistar rat at postnatal day 28, reached a peak in adult.

原位杂交显示谷氨酸诱导Wistar大鼠惊厥和P77PMC大鼠听源性惊厥后脑内IL-1βmRNA表达情况。结果发现，两种不同惊厥模型大鼠惊厥后脑内IL-1βmRNA表达存在明显的差异。谷氨酸引起惊厥诱导脑内皮层、海马和丘脑IL-1βmRNA表达增高的程度远较P77PMC大鼠听源性惊厥为低，而且惊厥后IL-1βmRNA表达增加较慢，于4-8h达高峰，而听源性惊厥可于惊厥后2h迅速达高峰。但两种形式惊厥诱导脑内IL-1βmRNA表达最高的部位均是海马。

MethodsNonheparinized autohemic blood of the rat was taken out from rat"s femoral artery and injected into its caudate nucleus immediately to establish a model of intracerebral hemorrhage.The changes of edema in the ipsilateral bassal ganglia , ipsilateral cortex, contralateral bassal ganglia and contralateral cortex were measured at 1,2,3,5 and 7 days respectively after intracerebral hemorrhage. The rat"s packed red blood cells, lysed red blood cells and hemoglobins at different concentrations were injected respectively into the rat"s caudate nucleus. The changes of edema in various regions of the brain at different time were measured as above. 5U thrombin was injected into the rat"s caudate nucleus and the changes of edema in various regions of the brain at different time were measured as above.

自体股动脉取血，并采用自体未肝素化新鲜血回注法建立大鼠尾状核出血模型，观察脑出血后1，2，3，5，7天血肿同侧基底节区、血肿同侧对应的皮质区、血肿对侧对应的基底节区及血肿对侧对应的皮质区脑组织水分含量的变化；分别以自体浓缩红细胞(PRBC，50％)、溶解红细胞(LRBC，50％)、不同浓度的大鼠血红蛋白注入大鼠尾状核，并观察不同时间不同部位脑组织水分含量的变化；以5U凝血酶注入大鼠尾状核，观察不同时间不同部位的脑组织水分含量的变化。

The animal model of this method system have, the characteristics of the high fat, high leptin, high Ins, and match with the characteristic of clinical and the pathologic of simple obesity. This studies showed: The acupuncture can obviously reduce the vaule of intaking food and water of the fat rats, and lower the body weight and fat; The acupuncture can urge the diameter, area, physical volume of white fat cell contract, Brown fat tissue of fat rat group surroundings vascular containing large quantity of white fat cell, the acupuncture group was less. this showed: The acupuncture enhanced the white fat cell metabolism, and promotesed the white fat cell to convert to brown fat cell; The frequency of spontaneous electric of nerve cell of pvn of the fat rat is high, the acupuncture counld depress the spontaneous electric of nerve cell of pvn, This showed: the acupuncture can depress the appetite passing to adjust function of pvn nerve; The monoaminergic neurotransmitter of inside of the fat rat brain is disfunction, the acupuncture can rectify this disfunction, and adjust level of 5-HT, and affect appetite, and improve metabolism; The level of leptin and Ins of fat rat increased high, The level of it of acupuncture group decreased, compared with the fat group p.001, This showed: the fat rats have the defeat of leptin and Ins in the body, The acupuncture can lowering this defeat, The level of leptin and Ins of the fat rat in the brain is less than the normal group, The level of leptin of the acupuncture group is high than the fat group, This showed: the acupuncture can increase the transportation of leptin from blood to brain.

本方法所制肥胖大鼠模型具有高体重、高脂、高leptin和高Ins血症的特点，符合人类单纯性肥胖病的临床和病理特征；实验研究显示：针灸能明显减少肥胖大鼠的摄水、摄食量及降低其体重、体脂；针灸能促使白色脂肪细胞直径、面积、体积缩小，减少肥胖大鼠棕色脂肪组织血管周围白色脂肪细胞数量，显示：针灸增强了白色脂肪细胞的代谢，促进了白色脂肪细胞向棕色脂肪细胞的转化：肥胖大鼠PVN神经细胞自发放电频率增加，脑内单胺递质紊乱，针灸通过抑制PVN亢奋的自发放电，调整5-HT水平，达到影响食欲，改善代谢的作用；肥胖大鼠血中leptin及Ins水平增高，与正常组大鼠比有明显差异，提示大鼠体内存在leptin及Ins抵抗，针灸后肥胖大鼠随着体重体脂的下降，血中leptin、Ins水平降低，与肥胖组比均有显著性差异，而针灸后大鼠脑内leptin增加，与肥胖组比P.05，提示：针灸具有改善leptin、Ins抵抗及增加leptin脑内转运的作用。

The absorption and distribution of chromium were studied in ryeusing nutrient culture technique and pot experiment.

采用不同浓度K2CrO4(0，0.4，0.8和1.2 mmol/L)的Hoagland营养液处理黑麦幼苗，测定铬在黑麦体内的亚细胞分布、铬化学形态及不同部位的积累。

By analyzing theory foundation of mathematical morphology in the digital image processing, researching morphology arithmetic of the binary Image, discussing two basic forms for the least structure element: dilation and erosion.

通过分析数学形态学在图像中的理论基础，研究二值图像的形态分析算法，探讨最小结构元素的两种基本形态：膨胀和腐蚀；分析了数学形态学复杂算法的基本原理，把数学形态学的部分并行处理理念引入到家实际应用中。