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One hand mechanical obstruct led to the increase of veinous resistance and the obstacle of microcirculation, the other hand the adhesive PMN was activated in excess, the white blood cells released a lot of enzymes, in which PMN-elastase can decompose the components of cell and many albumens, inclusive of immunoglobulin、alexin and fibrication. These components induced the injury of the pancreatic capillary vessels and cell and lysosome enzy made the tissue protein hydrolyze and produced unsaturated fatty acids, which destroyed the structure and function of cellar membrane. The inflammatory cellar factors activate other immunocytes to produce the injury and necrosis of tissue, which aggravated the pathological injury and led to shock、pyaemia and MODS. So ICAM-1 and LFA-1 played an important role in SAP. Frossard found that the expression of ICAM-1 in the rat model, especially in serum、pancreas and lung. All these showed ICAM-1 is an important factor in AP and concomitant lung injury.

胰腺小叶组织局部血管EC首先被激活,ICAM-1表达升高,与被激活的PMN表面表达的LFA-1相结合,"PMN-EC"相互作用加剧,一方面机械性阻塞毛细血管导致静脉阻力增加、微循环障碍;另一方面粘附的PMN过度吞噬或激活,当白细胞吞噬的颗粒不能被封闭隔离,连同细胞内的酶被释放出来,其中的PMN-elastase能够降解细胞基质中各种成分,水解多种蛋白,加重胰腺的毛细血管内皮细胞和腺泡的损伤;释放的溶酶体酶使组织蛋白水解,产生的不饱和脂肪酸引发脂质过氧化方应,破坏细胞膜的结构和功能;释放的炎性细胞因子,激发其他的免疫细胞的功能,导致进一步的组织损伤和坏死,加重SAP的病理损伤,最终导致休克、脓毒血症及多器官功能障碍等严重后果。

Objective To evaluate the possible role of alkaloid sinomenineon chronic rejection in rat heart transplantation model.

目的 探讨青藤碱对大鼠心脏移植慢性排斥反应抑制作用的可能机制。

Objective To compare on affection between cryotherapy and immunosuppressive agent for alloˉgraft of rat sciatic nerve.

目的 探讨应用冷冻法与免疫抑制剂法对同种异体鼠坐骨神经再生效果的比较。

Objective To explore the effects of Insulin on both bone mass and bone biomechanics of alloxan diabetic rat.

目的 探讨胰岛素对四氧嘧啶糖尿病大鼠骨量和骨生物力学方面的影响。

The results showed that the reaction time was 5 h,reaction temperature was 60℃,the molar ration of allyl chloride to hydroxyl was 1.5,the molar rat...

实验结果表明,最佳工艺条件为反应时间5 h、反应温度60℃、烯丙基氯用量为1.5、季铵盐催化剂用量为聚乙二醇物质的量比的5%,聚乙二醇封端率达到85%以上。

The mechanism of PPS accelerating IEC-6 cells migration was also researched with gene-chip technique. The Altas Clontech Rat cDNA Chip which consisted of 1176 spots representing different functional categories such as heat shock/stress, cell cycle, transcription factors, hormones, metabolism, etc was used. Result showed in cell migration model of IEC-6 cell line, compared with control group, expression of 38 genes in total 1176 genes varied in cells treated by PPS, including 21 genes up-regulated and 17 genes down-regulated. Date analyze showed the mechanism of PPS accelerating IEC-6 cells migration mainly related with promoting the numbers and activity of cellular ion channel, especially 〓 channel.

从以上实验结果中我们可以得出以下结论:四君子汤总多糖具有促进IEC-6细胞增殖、迁移、粘附的作用;四君子汤总多糖无论是对IEC-6细胞增殖、或者迁移的作用均优于各单味药多糖,可能是各种单味药多糖综合作用的结果;多糖可能是四君子汤"益气健脾"药效的主要成分;小肠上皮细胞可能是四君子汤总多糖的作用靶点之一,提示临床采用四君子汤及"益气健脾"法治疗"脾虚证"的疗效机制可能与增强机体的整体免疫和肠道粘膜免疫功能有关。

AIM To study the feasibility of establishing Alzheimer′s disease rat model with aluminum chloride by intrathecal injection.

目的 探讨鞘内注射AlCl3建立阿尔茨海默病大鼠模型的可行性。

Objective To investigate the effects of aluminum on differentiation of rat neural stem cells in vitro.

目的 探讨铝对大鼠神经干细胞向神经元样细胞分化的影响。

Objective To study the effect of lycopene on the function of pulmonary alveolar macrophagesof rat's acute lung injury.

目的 观察番茄红素对急性肺损伤大鼠肺泡巨噬细胞吞噬功能的影响。

RESULTS: The sequences of cloned adult rat Nogo gene segments (570-691 and 1028-1089 amine acid residues) were identical with those earlier reported.

结果: 获得成年SD大鼠Nogo(570~691和1028~1089氨基酸残基)的基因,测序结果与已发表的基因序列相一致。

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但我们并不在乎沙场中的显露。

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啊!不用提了。提到肉,真是糟透了。

Tristan, I have nowhere to send this letter and no reason to believe you wish to receive it.

Tristan ,我不知道把这信寄到哪里,也不知道你是否想收到它。